Roxithromycin
- CAS No.
- 80214-83-1
- Chemical Name:
- Roxithromycin
- Synonyms
- Roxid;Rulid;Roxithromycin Solution, 100ppm;Brilid;Overal;RU 965;Surlid;Assoral;Forilin;biaxsig
- CBNumber:
- CB1707342
- Molecular Formula:
- C41H76N2O15
- Molecular Weight:
- 837.05
- MOL File:
- 80214-83-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:01
| Melting point | 111-118?C |
|---|---|
| alpha | D25 -77.5 ±2° (c = 0.45 in chloroform) |
| Boiling point | 864.7±75.0 °C(Predicted) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| Flash point | >110°(230°F) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | chloroform: soluble10mg/mL |
| pka | pKa 9.27±0.01(H2O t = 25.0 I = 0.15 (KCl)) (Uncertain) |
| form | powder |
| color | White to off-white |
| Water Solubility | Soluble in water to 18µg/ml |
| Merck | 14,8276 |
| InChIKey | RXZBMPWDPOLZGW-HEWSMUCTSA-N |
| CAS DataBase Reference | 80214-83-1 |
| EPA Substance Registry System | Erythromycin, 9-[O-[(2-methoxyethoxy)methyl]oxime], (9E)- (80214-83-1) |
Roxithromycin price More Price(2)
Roxithromycin Chemical Properties,Uses,Production
Description
Roxithromycin, an oxime ether derivative of erythromycin, is a new macrolide antibiotic of high potency and long duration. Its in v i m activity spectrum is similar to that of erythromycin, but is superior to the latter against Legionella, Mycoplasma and Chlamydia.
Chemical Properties
White Solid
Uses
Roxithromycin was one of the new generation erythromycins introduced in the 1980s. Improved acid stability was achieved by converting the 9-keto group to the more stable oxime and alkylation of the oxime to provide the methoxyethoxymethyl ether oxime. In vivo, roxithromycin exhibits higher tissue levels and a longer half-life while being slightly less potent than erythromycin in vitro.
Antimicrobial activity
Activity against common pathogens is comparable to that of erythromycin. It is active against L. monocytogenes, C. jejuni, H. ducreyi, G. vaginalis, Bord. pertussis, C. diphtheriae, B. burgdorferi, H. pylori, the M. avium complex, Chlamydia spp., and U. urealyticum.
Pharmaceutical Applications
A semisynthetic derivative of erythromycin A formulated for oral use.
Side effects
It is generally well tolerated, adverse effects being described in 3–4% of patients, mostly gastrointestinal disturbance (abdominal pain, nausea and diarrhea). Headache, weakness, dizziness, rash and reversible changes in liver function tests and increased eosinophils and platelets have also been described.
Roxithromycin Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
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| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
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| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
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| Century Pharmaceuticals Ltd | +91-2652361581 +91-2652361581 | Gujarat, India | 53 | 58 | Inquiry |
| Ebenezer Industries | Gujarat, India | 96 | 58 | Inquiry | |
| Kopran Ltd | +91-9920289074 +91-9820220525 | Maharashtra, India | 21 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SNECOFRi Pvt Ltd | 58 |
| KARPSCHEM LABORATORIES | 58 |
| Murli Krishna Exports Pvt Ltd | 58 |
| Medi Pharma Drug House | 58 |
| Envee Drugs Pvt Ltd | 58 |
| Ralington Pharma | 58 |
| Alembic Pharmaceuticals Limited | 58 |
| Century Pharmaceuticals Ltd | 58 |
| Ebenezer Industries | 58 |
| Kopran Ltd | 58 |
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