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2-Methoxyethoxymethyl chloride

2-Methoxyethoxymethyl chloride Structure
CAS No.
3970-21-6
Chemical Name:
2-Methoxyethoxymethyl chloride
Synonyms
MEM CHLORIDE;1-CHLOROMETHOXY-2-METHOXYETHANE;MEM Chlordie;MEM chloride,94%;2-Methoxyethoxymethy;2-MethoxyethoxymethyL;1-Chloro-2,5-dioxahexane;Roxithromycin side chain;Roxithromycin Impurity 15;METHOXYETHOXYCHLOROMETHANE
CBNumber:
CB6332734
Molecular Formula:
C4H9ClO2
Molecular Weight:
124.57
MOL File:
3970-21-6.mol
MSDS File:
SDS
Modify Date:
2024/3/28 17:11:29

2-Methoxyethoxymethyl chloride Properties

Melting point 200-202 °C
Boiling point 50-52 °C/13 mmHg (lit.)
Density 1.091 g/mL at 25 °C (lit.)
refractive index n20/D 1.427(lit.)
Flash point >230 °F
storage temp. 2-8°C
solubility Chloroform, Methanol
form Liquid
Specific Gravity 1.091
color Clear colorless to yellow
Water Solubility It hydrolyzes with water.
Sensitive Moisture Sensitive
BRN 1900576
Exposure limits ACGIH: TWA 0.001 ppm
InChIKey BIAAQBNMRITRDV-UHFFFAOYSA-N
CAS DataBase Reference 3970-21-6(CAS DataBase Reference)
NIST Chemistry Reference «BETA»-methoxyethoxymethyl chloride(3970-21-6)
EPA Substance Registry System Ethane, 1-(chloromethoxy)-2-methoxy- (3970-21-6)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H226-H302-H315-H319-H331-H335-H350
Precautionary statements  P210-P301+P312-P303+P361+P353-P304+P340+P311-P305+P351+P338-P308+P313
Hazard Codes  T
Risk Statements  45-10-36/37/38-20/21/22-46-40-23/24/25-20/22
Safety Statements  53-26-36/37/39-45-16-23
RIDADR  UN 2810 6.1/PG 2
WGK Germany  3
10-21
Hazard Note  Toxic
TSCA  Yes
HazardClass  3
PackingGroup  III
HS Code  29091990
NFPA 704
2
2 1

2-Methoxyethoxymethyl chloride price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 357480 2-Methoxyethoxymethyl chloride technical grade 3970-21-6 5G ₹3074.3 2022-06-14 Buy
Sigma-Aldrich(India) 357480 2-Methoxyethoxymethyl chloride technical grade 3970-21-6 25G ₹12946.7 2022-06-14 Buy
ALFA India ALF-L01050-14 2-Methoxyethoxymethyl chloride, 94% 3970-21-6 25g ₹8318 2022-05-26 Buy
ALFA India ALF-L01050-06 2-Methoxyethoxymethyl chloride, 94% 3970-21-6 5g ₹3503 2022-05-26 Buy
TCI Chemicals (India) M0680 2-Methoxyethoxymethyl Chloride min. 95.0 % 3970-21-6 25ML ₹7800 2022-05-26 Buy
Product number Packaging Price Buy
357480 5G ₹3074.3 Buy
357480 25G ₹12946.7 Buy
ALF-L01050-14 25g ₹8318 Buy
ALF-L01050-06 5g ₹3503 Buy
M0680 25ML ₹7800 Buy

2-Methoxyethoxymethyl chloride Chemical Properties,Uses,Production

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

2-Methoxyethoxymethyl Chloride is an OH-protecting reagent. 2-Methoxyethoxymethyl Chloride is used in the modification of antibiotics.

Purification Methods

Possible impurities are methoxyethanol (b 124o/atm), HCHO and HCl which can be removed below the boiling point of MEMCl. Purify MEMCl by fractional distillation in a vacuum. If too impure, prepare it from methoxyethanol (152g) and s-trioxane (66g) by bubbling a stream of dry HCl (with stirring) until a clear mixture is obtained. Dilute with pentane (900mL), dry (3hours over 100g MgSO4, at 5o), evaporate and the residue is distilled in a vacuum. It is MOISTURE SENSITIVE and TOXIC. The MEM.NEt3+Cl-salt, prepared by reaction with 1.3 equivalents of Et3N (16hours/25o) and dried in a vacuum, has m 58-61o, and is moisture sensitive. [Corey et al. Tetrahedron Lett 809 1976, Yoshimatsu et al. J Org Chem 59 1011 1994, Greene & Wuts Protective Groups in Organic Synthesis edn, J Wiley & Sons NY 1991.] Carcinogen.

2-Methoxyethoxymethyl chloride Preparation Products And Raw materials

Global( 282)Suppliers
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Sris Synthesis Pvt Ltd., +91-9989522441 +91-9989522441 Hyderabad, India 282 58 Inquiry
AMINO ORGANICS +919866989891 Hyderabad, India 275 58 Inquiry
JSK Chemicals +919879767970 Gujarat, India 3756 58 Inquiry
anjali labs +91-9763681015 +91-9860682220 Maharashtra, India 19 58 Inquiry
OCEAN TRADING CORPORATION +91(22) 24921669 New Delhi, India 6211 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Alfa Aesar 1 800 209 7001 Maharashtra, India 6913 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
S. R. Chemical Specialities 08048965126 Hyderabad, India 90 58 Inquiry
ALKOXYETHOXYMETHYLCHLORIDE BETA-METHOXYETHOXYMETHYL CHLORIDE ETHYLENE GLYCOL CHLOROMETHYL METHYL ETHER 1-(Chloromethoxy)-2-methoxyethane~MEM chloride Alcoxyethoxymethylchloride Methoxxxy ethoxy Chloromethane 2-Methoxyethoxymethyl chloride, technical grade 2-METHOXYETHOXYMETHYL CHLORIDE MEM Chlordie MEM CHLORIDE (2-METHOXYETHOXYMETHYL CHLORIDE) METHOXYETHOXYCHLOROMETHANE β-Methoxyethoxymethyl chloride, MEM-chloride MEM chloride,94% 2-Methoxyethoxymethy 1-Methoxy-2-(chloromethoxy)ethane 2,5-Dioxahexyl chloride, tech MEM chloride, 1-(Chloromethoxy)-2-methoxyethane, 2-Methoxyethoxymethyl chloride 1-Chloromethoxy-2-methoxyethane Ethylene Glycol Chloromethyl Methyl Ether MEM-Chloride MethoxyethoxyMethylchlorid 1-(chloromethoxy)-2-methoxy-ethan 1-Chloro-2,5-dioxahexane 2-Methoxy-1-(Chloromethoxy) Ethane, 1-(chloromethoxy)-2-methoxy- 1-(2-pyridinylsulfonyl)benzotriazole Chloride:Alcoxyethoxylmethylchloride 2-MethoxyethoxymethylChloride> 2-Methoxyethoxymethyl chloride, 95%, for synthesis 2-MethoxyethoxymethyL β-Methoxyethoxymethyl Chloride Or Mem-Chloride MEM CHLORIDE 1-CHLOROMETHOXY-2-METHOXYETHANE 2-Methoxyethyl chloromethyl ether 2-Methoxyethoxychloromethane Roxithromycin side chain Roxithromycin Impurity 15 3970-21-6 CH3OCH2CH2OCH2Cl CH3OCH22OCH2Cl C4H9ClO2 Protection and Derivatization Protecting and Derivatizing Reagents Others Synthetic Reagents Protection & Derivatization Reagents (for Synthesis) Protection & Derivatization Reagents (for Synthesis) Synthetic Organic Chemistry