Triamcinolone
- CAS No.
- 124-94-7
- Chemical Name:
- Triamcinolone
- Synonyms
- Cinolone;(8S,9R,10S,11S,13S,14S,16R,17S)-9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one;Volon;0-dione;Celeste;cl19823;omcilon;CL 19823;Kenacort;Omicilon
- CBNumber:
- CB1734678
- Molecular Formula:
- C21H27FO6
- Molecular Weight:
- 394.43
- MOL File:
- 124-94-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/12/18 14:07:02
| Melting point | 262-263 °C(lit.) |
|---|---|
| Boiling point | 587.5±50.0 °C(Predicted) |
| alpha | 69 º (c=2, DMF) |
| Density | 1.1703 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMF: soluble20 mg/mL |
| pka | 11.57±0.70(Predicted) |
| form | Solid |
| color | Crystals |
| optical activity | [α]25/D +69°, c = 2 in DMF |
| Water Solubility | 79.99mg/L(25 ºC) |
| Merck | 9595 |
| InChIKey | GFNANZIMVAIWHM-OBYCQNJPSA-N |
| CAS DataBase Reference | 124-94-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Triamcinolone(124-94-7) |
| EPA Substance Registry System | Triamcinolone (124-94-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H351 |
| Precautionary statements | P280 |
| Hazard Codes | Xn |
| Risk Statements | 40 |
| Safety Statements | 22-36 |
| WGK Germany | 3 |
| RTECS | TU3850000 |
| HS Code | 2937220000 |
| Hazardous Substances Data | 124-94-7(Hazardous Substances Data) |
| Toxicity | LD50 subcutaneous in mouse: > 4gm/kg |
Triamcinolone price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T6376 | Triamcinolone | 124-94-7 | 50MG | ₹3377.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T6376 | Triamcinolone | 124-94-7 | 250MG | ₹9904.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T6376 | Triamcinolone | 124-94-7 | 1G | ₹27787.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T6376 | Triamcinolone | 124-94-7 | 5G | ₹103367.93 | 2022-06-14 | Buy |
Triamcinolone Chemical Properties,Uses,Production
Description
A natural extension of corticoid research involved examination of compounds containing both a 9α-fluoro group and a double bond between positions 1 and 2. Triamcinolone (9-fluoro-11β, 16α, 17, 21-tetrahydroxypregna- 1,4-diene-3,20-dione), introduced in 1958, combines the structural features of a ?1 -corticoid and a 9α-fluoro corticoid. As mentioned previously, the 9α-fluoro group increases the anti-inflammatory potency, but it also markedly increases the mineralocorticoid potency. This is undesirable if the drug is to be used internally for the treatment of rheumatoid arthritis. By inserting a 16α-hydroxy group into the molecule, one can decrease the mineralocorticoid activity.
Chemical Properties
White, crystalline powder. Insoluble in water; slightly soluble in usual organic solvents; soluble in dimethylformamide.
Uses
Triamcinolone is a glucocorticoid. Triamcinolone is used as an antiasthmatic (inhalant); antiallergic (nasal).
Definition
ChEBI: A C21-steroid hormone that is 1,4-pregnadiene-3,20-dione carrying four hydroxy substituents at positions 11beta, 16alpha, 17alpha and 21 as well as a fluoro substituent at position 9. sed in the form of its 16,17-acetonide to treat various skin infections.
Indications
Intralesional bleomycin, a cytotoxic drug that inhibits DNA synthesis, is effective for all varieties of recalcitrant warts. Various concentrations of the drug have been used, although the total dose must be carefully tracked over time to avoid potential systemic toxicity.
Clinical Use
Triamcinolone to be used topically is generally dispensed as its more potent and lipophilic acetonide, a 16α,17α-methylenedioxy cyclic ketal or isopropylidene derivative. It is effective in the treatment of psoriasis and other corticoid-sensitive dermatologic conditions. Topically, triamcinolone acetonide is a more potent derivative of triamcinolone and is approximately eight times more active than prednisolone.
Side effects
Even though triamcinolone has an apparently decreased tendency to cause salt and water retention and edema and may induce sodium and water diuresis, it causes other unwanted side effects, including anorexia, weight loss, muscle weakness, leg cramps, nausea, dizziness, and a general toxic feeling.
Safety Profile
Poison by subcutaneous route.An experimental teratogen. Other experimentalreproductive effects. Human mutation data reported.When heated to decomposition it emits toxic fumes of F??.An anti-inflammatory and antiallergic agent.
Triamcinolone Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Coral Drugs Pvt Ltd | +91-1244518100 +91-8199986118 | New Delhi, India | 24 | 58 | Inquiry |
| Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
| Vamsi Labs Ltd | +91-2172357274 +91-9891966300 | Maharashtra, India | 43 | 58 | Inquiry |
| Anuh Pharma Ltd (SK GROUP) | +912266227575 | Maharashtra, India | 38 | 58 | Inquiry |
| Chempifine Chemicals | +91-2225667766 +91-2225667766 | Punjab, India | 144 | 58 | Inquiry |
| Maharshi Pharma Chem | +91-7940359347 +91-7433927173 | Gujarat, India | 24 | 58 | Inquiry |
| Prachem Laboratories | +91-7948993109 +91-7383072020 | Gujarat, India | 44 | 58 | Inquiry |
| Avik Pharmaceutical Limited | +91-9821827247 +91-7600019006 | Maharashtra, India | 22 | 58 | Inquiry |
| Dy - Mach Pharma | +91-2265018321 +91-2226833227 | Maharashtra, India | 18 | 58 | Inquiry |
| Envee Drugs Pvt Ltd | +91-02682559595 +91-8866665858 | Gujarat, India | 36 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Coral Drugs Pvt Ltd | 58 |
| Gonane Pharma | 58 |
| Vamsi Labs Ltd | 58 |
| Anuh Pharma Ltd (SK GROUP) | 58 |
| Chempifine Chemicals | 58 |
| Maharshi Pharma Chem | 58 |
| Prachem Laboratories | 58 |
| Avik Pharmaceutical Limited | 58 |
| Dy - Mach Pharma | 58 |
| Envee Drugs Pvt Ltd | 58 |
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