Cyclosporin C

CAS No.: 59787-61-0

Chemical Name:: Cyclosporin C

Synonyms: CL246;WF-3484;CS-2545;CS-2546;CYCLOSPORIN C;Thr2-cyclosporine;Cyclosporin C, >=95%;Cyclosporine IMpurity-C;Cyclosporin Impurity C;Cyclosporine Impurity 3

CBNumber:: CB2153074

Molecular Formula:: C62H111N11O13

Molecular Weight:: 1218.61

MOL File:: 59787-61-0.mol

MSDS File:: SDS

Modify Date:: 2023/6/30 15:45:59

Request For Quotation

Cyclosporin C Properties

Melting point	144-1460C
alpha	D20 -255° (c = 0.5 in chloroform); D20 -182° (c = 0.5 in methanol)
Boiling point	1316.0±65.0 °C(Predicted)
Density	1.033±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: ≥10mg/mL
pka	13.06±0.70(Predicted)
form	Colorless to off-white crystalline solid.
color	White to Off-White
InChIKey	JTOKYIBTLUQVQV-PCACHRFWSA-N
CAS DataBase Reference	59787-61-0

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Danger

Hazard statements

H362-H350-H302

Precautionary statements

P264-P270-P301+P312-P330-P501-P201-P260-P263-P264-P270-P308+P313

WGK Germany

NFPA 704

	0
2		0

Cyclosporin C Chemical Properties,Uses,Production

Description

Cyclosporin C is a fungal metabolite that has been found in T. inflatum and has diverse biological activities, including antifungal, antiviral, and immunosuppressant properties. It is active against isolates of B. cinerea, A. niger, and Alternaria, Mucor, and Penicillium species (MICs = 0.1-5 μg/ml). Cyclosporin C (15 μg/ml) inhibits vaccinia virus replication in infected BSC40 cells by 98.82%. It inhibits lymphocyte proliferation induced by the mitogens concanavalin A (ConA; ), phytohemagglutinin L (PHA), and pokeweed mitogen (PWM), as well as proliferation induced by alloantigen in mixed lymphocyte culture when used at a concentration of 100 ng/ml. Cyclosporin C (100 ng/ml) inhibits the local graft versus host (GVH) reaction in mice receiving splenocyte grafts.

Chemical Properties

White Solid

Uses

Cyclosporin C is a minor analogue of the cyclosporin complex produced by a number of fungal species, including Trichoderma, Tolypocladium, Fusarium, Nectria and Acremonium. Cyclosporin C possesses immunosuppressant activity but has been much less extensively investigated than the major analogue, cyclosporin A.

Cyclosporin C Preparation Products And Raw materials

Raw materials

Preparation Products

Cyclosporin A

Cyclosporin C Suppliers

Global( 187)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9338	55	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	China	3424	58	Inquiry
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	China	3000	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
SIMAGCHEM CORP	+86-13806087780	China	17367	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
SynZeal Research Pvt Ltd	58
Pharma Affiliates	58
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Chengdu Biopurify Phytochemicals Ltd.	58
Shaanxi Pioneer Biotech Co., Ltd .	58
BOC Sciences	58
SIMAGCHEM CORP	58

59787-61-0(Cyclosporin C)Related Search:

Thiophanate-methyl Phenylmethylsulfonyl fluoride Cyclosporin A Kresoxim-methyl Hexamethylphosphoramide

CYCLOSPORIN H STAUROSPORINE Methylparaben METHYL THIOPHENE-2-CARBOXYLATE Methyl acrylate

VALINOMYCIN Bensulfuron methyl Dimethyl sulfone (R)-(-)-2-Amino-3-methyl-1-butanol CYCLOSPORIN D

Methyl Parathion-methyl Methyl bromide

chevron_left

1of4

chevron_right

CYCLOSPORIN C Thr2-cyclosporine Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-threonyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl] (3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Thr-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-) WF-3484 7-L-Threoninecyclosporin A Cyclosporine IMpurity-C 7-L-Threoninecyclosporin A, WF 3484 7-Threonine-cyclosporin A Cyclosporin C, >=95% Cyclosporine C/Cyclo[L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-threonyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl] 30-(1-hydroxyethyl)-33-(1-hydroxy-2-methylhex-4-enyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriaconta CS-2545 CS-2546 cyclo-[MeBmt-Thr-Sar-MeLeu-Val-MeLeu-Ala-D-Ala-MeLeu-MeLeu-MeVal] Cyclosporine EP Impurity C CL246 Cyclosporin Impurity C Cyclosporin Impurity 3(Cyclosporin C) Cyclosporin A, 7-L-threonine- Cyclosporine Impurity 3 (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-((1R,2R,E)-1-Hydroxy-2-methylhex-4-en-1-yl)-30-((R)-1-hydroxyethyl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone (3R,6S,9S,12R,15R,18S,21R,24S,30R,33S)-30-(1-Hydroxyethyl)-33-(1-hydroxy-2-methylhex-4-enyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,1 (3R,6S,9S,12R,15R,18S,21R,24S,30R,33S)-30-(1-Hydroxyethyl)-33-(1-hydroxy-2-methylhex-4-enyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone Cyclosporin C, EvoPure? 59787-61-0 69787-61-0 59767-61-0 C62H111N11O13 Intermediates & Fine Chemicals Peptides Pharmaceuticals ACTIVE PHARMACEUTICAL INGREDIENTS