SODIUM PROPIONATE
- CAS No.
- 6700-17-0
- Chemical Name:
- SODIUM PROPIONATE
- Synonyms
- MAGNESIA 87910;MAGGRAN(R) NPR;SODIUMPROPIONATE,NF;SODIUM PROPIONATE HYDRATE;PROPIONIC ACID SODIUM SALT;Sodium Propionate (200 mg);METHYLACETIC ACID SODIUM SALT;PROPANOIC ACID SODIUM SALT HYDRATE
- CBNumber:
- CB2157845
- Molecular Formula:
- C3H5NaO2
- Molecular Weight:
- 96.06
- MOL File:
- 6700-17-0.mol
- Modify Date:
- 2023/4/23 13:52:06
SODIUM PROPIONATE Chemical Properties,Uses,Production
Chemical Properties
Sodium propionate occurs as colorless transparent crystals or as a granular, free-flowing, crystalline powder. It is odorless, or with a slight characteristic odor, and is deliquescent in moist air. Sodium propionate has a characteristic, slightly cheeselike taste, although by itself it is unpalatable.
Uses
Sodium Propionate Hydrate is a food preservative used for its antifungal ability towards grain products.
Production Methods
Sodium propionate is prepared by the reaction of propionic acid with sodium carbonate or sodium hydroxide.
Pharmaceutical Applications
As an excipient, sodium propionate is used in oral pharmaceutical
formulations as an antimicrobial preservative. Like propionic acid,
sodium propionate and other propionic acid salts are fungistatic
and bacteriostatic against a number of Gram-positive cocci.
Propionates are more active against molds than is sodium benzoate,
but have essentially no activity against yeasts.
Therapeutically, sodium propionate has been used topically in
concentrations up to 10% w/w alone or in combination with other propionates, caprylates, or other antifungal agents, in the form of
ointments or solutions for the treatment of dermatophyte infections.
Eye drops containing 5% w/v sodium propionate have also been
used.
In food processes, particularly baking, sodium propionate is
used as an antifungal agent; it may also be used as a flavoring agent
in food products. In veterinary medicine, sodium propionate is used
therapeutically as a glucogenic substance in ruminants.
Safety
Sodium propionate and other propionates are used in oral
pharmaceutical formulations, food products, and cosmetics. The
free acid, propionic acid, occurs naturally at levels up to 1% w/w in
certain cheeses.
Following oral consumption, propionate is metabolized in
mammals in a manner similar to that of fatty acids. Toxicity studies
in animals have shown sodium propionate and other propionates to
be relatively nontoxic materials.(2,3) In veterinary medicine, sodium
propionate is used as a therapeutic agent for cattle and sheep.
In humans, 6 g of sodium propionate has been administered
daily without harm.(2) However, allergic reactions to propionates
can occur.
LD50 (mouse, oral): 6.33 g/kg
LD50 (mouse, SC): 2.1 g/kg
LD50 (rabbit, skin): 1.64 g/kg
storage
Sodium propionate is deliquescent and should therefore be stored in an airtight container in a cool, dry place.
Incompatibilities
Incompatibilities for sodium propionate are similar to those of other weak organic acids.
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe. In
cheese products, propionates are limited to 0.3% w/w concentration;
a limit of 0.32% w/w is applied in flour and white bread rolls,
while a limit of 0.38% w/w is applied in whole wheat products.
Included in the FDA Inactive Ingredients Database (oral
capsules, powder, suspensions, and syrups). Included in nonparenteral
medicines licensed in the UK. Included in the Canadian List
of Acceptable Non-medicinal Ingredients.
SODIUM PROPIONATE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Magnesia GmbH | 0 41 31/8710-0 | Germany | 76 | 65 | Inquiry |
| Merck Schuchardt OHG | +49 (0) 8102 802 0 | Germany | 5831 | 74 | Inquiry |
| Dr. Ehrenstorfer GmbH | (0821) 90 60 80 | Germany | 5547 | 66 | Inquiry |
| AppliChem GmbH | +49 6151 93 57 0 | Germany | 1607 | 74 | Inquiry |
| VWR International | 800 932 5000 | United Kingdom | 6554 | 82 | Inquiry |
| Spectrum Chemicals & Laboratory Products | 310 516 8000 | United States | 6706 | 77 | Inquiry |
| ASDI Incorporated | 888 577 ASDI | United States | 6928 | 67 | Inquiry |
| Advance Scientific & Chemical | (954) 327-0900 | United States | 6434 | 71 | Inquiry |
| Whyte Chemicals | +44 (20) 8346-5946 | United Kingdom | 3755 | 50 | Inquiry |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | China | 9664 | 60 | Inquiry |
| Supplier | Advantage |
|---|---|
| Magnesia GmbH | 65 |
| Merck Schuchardt OHG | 74 |
| Dr. Ehrenstorfer GmbH | 66 |
| AppliChem GmbH | 74 |
| VWR International | 82 |
| Spectrum Chemicals & Laboratory Products | 77 |
| ASDI Incorporated | 67 |
| Advance Scientific & Chemical | 71 |
| Whyte Chemicals | 50 |
| Spectrum Chemical Manufacturing Corp. | 60 |
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