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Cysteamine

Cysteamine Structure
CAS No.
60-23-1
Chemical Name:
Cysteamine
Synonyms
CYSTEAMINE;mercaptamine;2-MERCAPTOETHYLAMINE;Cysteamin;Cysteamide;Cisteamina;2-amino-ethanethio;2-Amino-1-ethanethiol;β-MEA;L-1573
CBNumber:
CB2223766
Molecular Formula:
C2H7NS
Molecular Weight:
77.15
MOL File:
60-23-1.mol
MSDS File:
SDS
Modify Date:
2024/4/25 11:11:10
Request For Quotation

Cysteamine Properties

Melting point 95°C
Boiling point 130 °C
Density 0.934 (estimate)
refractive index 1.5300 (estimate)
storage temp. 2-8°C
Water Solubility Soluble in water
form Powder
pka 8.35(at 25℃)
color White to slightly yellow
Merck 14,2779
BRN 635649
Stability Stable, but may be air-sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference 60-23-1(CAS DataBase Reference)
EPA Substance Registry System Cysteamine (60-23-1)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P264-P270-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36
RIDADR  3259
WGK Germany  3
RTECS  KJ0175000
F  1-3-10-13-34
HS Code  29309090
Toxicity LD50 in mice (mg/kg): 625 orally; 250 i.p. (Klayman); (Srivastava, Field)
NFPA 704
0
2 1

Cysteamine price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) M9768 Cysteamine ~95% 60-23-1 5G ₹8703.3 2022-06-14 Buy
Sigma-Aldrich(India) M9768 Cysteamine ~95% 60-23-1 25G ₹26131.55 2022-06-14 Buy
Sigma-Aldrich(India) M9768 Cysteamine ~95% 60-23-1 50G ₹45908.83 2022-06-14 Buy
Sigma-Aldrich(India) 641022 2-Mercaptoethylamine, polymer-bound 70-90?mesh, extent of labeling: 0.6-1.1?mmol/g loading, 1?% cross-linked with divinylbenzene 60-23-1 5G ₹19939.65 2022-06-14 Buy
Sigma-Aldrich(India) 641022 2-Mercaptoethylamine, polymer-bound 70-90?mesh, extent of labeling: 0.6-1.1?mmol/g loading, 1?% cross-linked with divinylbenzene 60-23-1 25G ₹48582.6 2022-06-14 Buy
Product number Packaging Price Buy
M9768 5G ₹8703.3 Buy
M9768 25G ₹26131.55 Buy
M9768 50G ₹45908.83 Buy
641022 5G ₹19939.65 Buy
641022 25G ₹48582.6 Buy

Cysteamine Chemical Properties,Uses,Production

Description

2-AMINOETHANETHIOL is the chemical compound with the formula HSCH2CH2NH2. It is the simplest stable aminothiol and a degradation product of the amino acid cysteine. It is often used as the hydrochloride salt, HSCH2CH2NH3Cl. The comparatively high melting point of cysteamine (95-97 °C), indicates that exists in a salt form.

Chemical Properties

2-AMINOETHANETHIOL is white powder

Uses

antihyperlipidemic, HMGCoA reductase inhibitor

Preparation

Cysteamine can also be prepared by the reaction of ethylenimine with hydrogen sulfide.
(NHCH2CH2) + H2S → HSCH2CH2NH2.

Definition

2-AMINOETHANETHIOL is an amine that consists of an ethane skeleton substituted with a thiol group at C-1 and an amino group at C-2.

Reactions

2-AMINOETHANETHIOL is used as the hydrochloride salt, as it readily oxidizes to the corresponding disulfide, in the presence of air. The amine portion of the molecule serves as a catalyst for this reaction.
4 HSCH2CH2NH2 + O2 → 2 NH2CH2CH2SSCH2CH2NH2 + 2 H2O.

Pharmaceutical Applications

Under the trade name Cystagon, cysteamine is used in the treatment of disorders of cystine excretion. Cysteamine cleaves the disulfide bond with cystine to produce molecules that can escape the metabolic defect in cystinosis and cystinuria.
It is also used for treatment of radiation sickness.
Cysteamine is used in the body to form the essential biochemical coenzyme A by combining with pantothenate and adenosine triphosphate.
In 2008, Raptor Pharmaceuticals started phase II clinical trials testing a delayed release (DR) preparation of cysteamine bitartrate for Huntington's disease. DR Cysteamine is also being investigated as a treatment for cystinosis, Batten disease, and non-alcoholic steatohepatitis.

Safety Profile

Poison by intravenous, subcutaneous, and intraperitoneal routesModerately toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of SO, and NOx,.

Purification Methods

It is soluble in H2O giving an alkaline reaction, and it has a disagreeable odour. A likely impurity is the disulfide cystamine which is not soluble in alkaline solution. Under a N2 atmosphere dissolve it in EtOH, evaporate to dryness and wash the white residue with dry pet ether, then sublime it at 0.1mm and store it under N2 at 0-10o in the dark. Its HgCl2 (2:3) complex has m 181-182o (from H2O), and its picrate has m 125-126o. [Mills & Bogert J Am Chem Soc 57 2328 1935, 62 1173 1940, Baddiley & Thain J Chem Soc 800 1952, Shirley Preparation of Organic Intermediates (J. Wiley) Vol 3 189 1951, Barkowski & Hedberg J Am Chem Soc 109 6989 1987, Beilstein 4 IV 1570.]

Cysteamine Preparation Products And Raw materials

Raw materials

Hydrogen Sulfide Ethyleneimine

Preparation Products

Thiacloprid 4-[[(2-aminoethyl)thio]methyl]-5-methylimidazole Fosthiazate N-(2-MERCAPTOETHYL)ACETAMIDE Coenzyme A
selenocystamine N-Benzylacetoacetamide 2-METHYLTHIAZOLIDINE 2,2'-Bithiazolidine (2Z)-3-Thiomorpholinylideneacetic acid ethyl ester
2-(3-Pyridyl)thiazolidine, 97% 3-Methylthiazolidine 2-PHENYL-1,3-THIAZOLANE
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Cysteamine Suppliers

Global( 297)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
MOLECRAFT LIFE SCIENCES PVT LTD +91 9581188881 Telangana, India 189 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Alfa Aesar 1 800 209 7001 Maharashtra, India 6913 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Medicon Health Care Private Limited 08047636319 Mumbai, India 2 58 Inquiry
Jyoti Group Of Companies 08048372843Ext 853 Maharashtra, India 4 58 Inquiry
Mercatum Technology Pvt. Ltd. 08048609359 Mumbai, India 1 58 Inquiry
Supplier Advantage
MOLECRAFT LIFE SCIENCES PVT LTD 58
Pharma Affiliates 58
TCI Chemicals (India) Pvt. Ltd. 58
CHEMSWORTH 30
CLEARSYNTH LABS LTD. 58
Alfa Aesar 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Medicon Health Care Private Limited 58
Jyoti Group Of Companies 58
Mercatum Technology Pvt. Ltd. 58

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Cysteamine Spectrum

2-AMINOETHANETHIOL(60-23-1)MS2-AMINOETHANETHIOL(60-23-1)1HNMR2-AMINOETHANETHIOL(60-23-1)IR12-AMINOETHANETHIOL(60-23-1)IR2

60-23-1(Cysteamine)Related Search:

LANTHIONINE Z-CYS(BZL)-OH N-Acetyl-L-cysteine D-PENICILLAMINE DISULFIDE CHES
N-ACETYL-DL-PENICILLAMINE S-CARBOXYMETHYL-L-CYSTEINE Pseudothiohydantoin Tiopronin D-Cystine
S-Methyl-L-cysteine 2-(BUTYLAMINO)ETHANETHIOL S-tert-Butylmercapto-l-cysteine Taurodeoxycholic acid sodium salt DL-Cysteine
S-Trityl-L-cysteine DL-PENICILLAMINE 2-Aminoethanethiol·hydrochloric acid,2-Aminoethanethiol hydrochloride ( cysteamine hydrochloride)
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2-Aminoethyl mercaptan 2-aminoethylmercaptan THIOETHANOLAMINE 2-MERCAPTOETHYLAMINE, POLYMER-BOUND 2-AMINOETHANETHIOL DECARBOXYCYSTEINE AURORA KA-7615 Beeaptan BETA-MERCAPTOETHYLAMINE 2-Aminoet-hylmercaptan 2-Mercaptoethanamine Ethanethiol, 2-aMino-(8CI,9CI) CysteaMine ~95% Cysteamine(β-MEA) Aminoethyl mercaptan Becaptan beta-Aminoethanethiol beta-Aminoethylthiol beta-MEA Cysteinamine Ethanethiol, 2-amino- Ethanethiolamine L-1573 Lambraten Lambratene Mecramine Mercamin Mercamine Mercaptamin 2-AMINOETHANETHIOL 156-57-0 -Mercaptoethylamine Merkamin Riacon 2-Aminoethanthiol 2-mercaptoethylamine free base 2,2,4-trimethyl-1,2-dihydroquinoline (oligomers) C01678 Cysteamine,β-Mercaptoethylamine, 2-Aminoethanethiol, 2-Mercaptoethylamine, Decarboxycysteine, Thioethanolamine Cysteamine 2-Mercaptoethylamine CYSTEAMINE HYDROCHLORIDE(P) β-Mercaptoethylamine, 2-Aminoethanethiol, 2-Mercaptoethylamine, Decarboxycysteine, Thioethanolamine cysteamine, β-Mercaptoethylamine, 2-Mercaptoethylamine, Decarboxycysteine, Thioethanolamine, Mercaptamine 2-mercaptoethylammonium JACS-60-23-1 2-Aminoethanethiol > Aminoethanethiol... cysteanine 2-AMINOETHANETHIOL USP/EP/BP β-MEA β-Mercaptoethylamine 2-Aminoethanethiol (Cysteamine) 2-Amino-1-ethanethiol 2-amino-ethanethio 2-MERCAPTOETHYLAMINE CYSTEAMINE Cysteamide Cysteamin mercaptamine