Coenzyme A
- CAS No.
- 85-61-0
- Chemical Name:
- Coenzyme A
- Synonyms
- COA;COA-SH;COENZYME A HYDRATE;Lucina;Coalip;Aluzime;Thiol-CoA;SHUIRUJIE;COENZYME A;CONENZYME A
- CBNumber:
- CB8854470
- Molecular Formula:
- C21H36N7O16P3S
- Molecular Weight:
- 767.53
- MOL File:
- 85-61-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/25 20:04:51
| Density | 1.96±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | PBS (pH 7.2): 10 mg/ml |
| form | A crystalline solid |
| pka | 9.6 (thiol); pK 6.4 (secondary phosphate); pK 4.0 (adenine NH3+) |
| color | White to light yellow |
| Merck | 13,2491 |
| BRN | 77809 |
| InChIKey | RGJOEKWQDUBAIZ-IBOSZNHHSA-N |
| SMILES | SCCNC(=O)CCNC(=O)[C@@H](C(COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](N2C3N=CN=C(N)C=3N=C2)[C@H](O)[C@@H]1OP(=O)(O)O)(C)C)O |
| LogP | -4.358 (est) |
| EPA Substance Registry System | Coenzyme A (85-61-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315-H335 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 1-10 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2933299090 | |||||||||
| NFPA 704 |
|
Coenzyme A price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C4282 | Coenzyme A hydrate ≥85% (UV, HPLC) | 85-61-0 | 10MG | ₹6040.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C4282 | Coenzyme A hydrate ≥85% (UV, HPLC) | 85-61-0 | 25MG | ₹11853.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C4282 | Coenzyme A hydrate ≥85% (UV, HPLC) | 85-61-0 | 100MG | ₹22169.6 | 2022-06-14 | Buy |
| ottokemi | C 0513 | CoASH (Coenzyme A-SH), 80% | 85-61-0 | 10mg | ₹6003 | 2022-05-26 | Buy |
| ottokemi | C 0513 | CoASH (Coenzyme A-SH), 80% | 85-61-0 | 25mg | ₹10044 | 2022-05-26 | Buy |
Coenzyme A Chemical Properties,Uses,Production
Description
Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-
Chemical Properties
yellowish lyophilisate
Uses
A hydrated form of Coenzyme A (CoA) is a useful biochemical research chemical, used in the preparation of high-yielding cell-free protein synthesis platforms.
Definition
ChEBI: Coenzyme A is a thiol comprising a panthothenate unit in phosphoric anhydride linkage with a 3',5'-adenosine diphosphate unit; and an aminoethanethiol unit. It has a role as an Escherichia coli metabolite, a mouse metabolite and a coenzyme. It is functionally related to an ADP. It is a conjugate acid of a coenzyme A(4-).
General Description
Coenzyme A (CoA) is a cofactor with a molecular weight of 797 Da. Its biological structure is formed from pantothenic acid (vitamin B5), cysteine and adenosine triphosphate through an evolutionarily conserved pathway. CoA is primarily involved in cellular oxidative pathways, including fatty acid beta-oxidation, carbohydrate, amino acid oxidation, and the Krebs cycle; as well as in lipid synthesis, protein modification, and membrane transport. CoA serves as a carrier for the activation of acyl groups, which can be transferred to amides, esters, or acid anhydrides. CoA can also be regulate a variety of metabolic processes at different levels as substrates, allosteric regulators, and through post-translational modifications of histones and other non-histone proteins. It is an essential cofactor in all organisms.
Purification Methods
The white powder is best stored in an inert atmosphere in the dark in sealed ampoules after drying in vacuo over P2O5 at 34o. It has UV: max 259 nm ( 16,800) in H2O. [Buyske et al. J Am Chem Soc 76 3575 1954.] It is soluble in H2O but insoluble in EtOH, Et2O and M2CO. It is readily oxidised in air and is best kept as the more stable trilithium salt [Moffat & Khorana J Am Chem Soc 83 663 1961; see also Beinert et al. J Biol Chem 200 384 1953, De Vries et al. J Am Chem Soc 72 4838 1950, Gregory et al. J Am Chem Soc 74 854 1952 and Baddiley Adv Enzymol 16 1 1955]. [Beilstein 26 III/IV 3663.]
Coenzyme A Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Green Vision Life Sciences Pvt Ltd. | +91-2067919200 +91-9404953243 | Maharashtra, India | 30 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Transiom Genomics | 08068441066Ext 367 | Gujarat, India | 10 | 58 | Inquiry |
| Oxsyns Biotech | +86-86-18382622232 +8618382622232 | China | 9 | 58 | Inquiry |
| Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | China | 5835 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Green Vision Life Sciences Pvt Ltd. | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
| Triveni chemicals | 58 |
| Transiom Genomics | 58 |
| Oxsyns Biotech | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | 58 |
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