Fenbufen
- CAS No.
- 36330-85-5
- Chemical Name:
- Fenbufen
- Synonyms
- bufemid;cl82204;napanol;cinopal;Cinopol;enbufen;lederfen;FENBUFEN;Fenbufen CRS;FENBUFENTABLETS
- CBNumber:
- CB2239125
- Molecular Formula:
- C16H14O3
- Molecular Weight:
- 254.29
- MOL File:
- 36330-85-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 184-187 °C (lit.) |
|---|---|
| Boiling point | 357.5°C (rough estimate) |
| Density | 1.1565 (rough estimate) |
| refractive index | 1.5600 (estimate) |
| storage temp. | 2-8°C |
| solubility | Very slightly soluble in water, slightly soluble in acetone, in ethanol (96 per cent) and in methylene chloride. |
| pka | pKa 4.3(H2O tunde?ned Iunde?ned) (Uncertain) |
| form | Solid |
| color | White to off-white |
| Water Solubility | 2.212mg/L(25 ºC) |
| Merck | 13,3990 |
| EPA Substance Registry System | [1,1'-Biphenyl]-4-butanoic acid, .gamma.-oxo- (36330-85-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310+P330 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 28-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DV1761000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2918300090 | |||||||||
| Toxicity | LD50 in various strains of mice, rats (mg/kg): 795-1673, 200-720 orally; 506-811, 265-575 i.p. (Bolte) | |||||||||
| NFPA 704 |
|
Fenbufen price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | F8755 | Fenbufen analytical standard | 36330-85-5 | 5G | ₹11615.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | F8755 | Fenbufen analytical standard | 36330-85-5 | 10G | ₹18900.45 | 2022-06-14 | Buy |
| ALFA India | ALF-H60557-06 | 4-(4-Biphenylyl)-4-oxobutyric acid, 96% | 36330-85-5 | 5g | ₹18574 | 2022-05-26 | Buy |
| ALFA India | ALF-H60557-03 | 4-(4-Biphenylyl)-4-oxobutyric acid, 96% | 36330-85-5 | 1g | ₹3584 | 2022-05-26 | Buy |
Fenbufen Chemical Properties,Uses,Production
Description
Fenbufen has been found to be an effective, well-tolerated drug for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Fenbufen is prepared by the Friedel-Crafts (aluminum chloride – nitrobenzene) acylation of biphenyl with succinic anhydride. The compound is metabolized in humans first to 4-hydroxy-4-biphenylbutyric acid (tmax 2.5 h) then to 4-biphenyl acetic acid (tmax 7.5 h). Both metabolites are more active than fenbufen itself and circulate for several hours (t1/2 10 h). This slow conversion of fenbufen to active metabolites having relatively long plasma half-lives allows for once a day dosing with this agent.
Chemical Properties
White Solid
Uses
Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory
General Description
Fenbufen belongs to the class of non-steroidal anti-inflammatory drugs, widely used as an antipyretic and analgesic in medical applications. Its mode of action involves the inhibition of cyclooxygenase enzyme and thereby prevents the synthesis of certain prostaglandins.
Trade name
Clincopal (Lederle, Spain), Lederfen (Lederle, UK), Napanol (Lederle, Japan).
Safety Profile
Poison by ingestion,intraperitoneal, and subcutaneous routes. Human systemiceffects by ingestion: cough, sweating, body temperature.An experimental teratogen. Other experimentalreproductive effects. An anti-inflammatory agent. Whenheated to decomposi
Fenbufen Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Dr. Jagath Reddy's Heterocyclics | 91-40-23773841 91-40-65572151 | New Delhi, India | 3886 | 42 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Saisri Hetero Cyclics (SSH) | 91-40-35570370 | Hyderabad, India | 262 | 58 | Inquiry |
| Pharmaffiliates Analytics & Synthetics (P) Ltd. | 91-172-5066494 | Haryana, India | 631 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Vyshno Bio Sciences | 91-7095439993 | Hyderabad, India | 239 | 58 | Inquiry |
| Oceanic Pharmachem Pvt., Ltd. (OPPL) | 91-22-42128600 | Maharashtra, India | 947 | 58 | Inquiry |
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