Phoxim | 14816-18-3

Phoxim Properties

Melting point	5.55°C
Boiling point	bp0.01 102°
Density	d420 1.176
vapor pressure	2.1×10^-3 Pa (20 °C)
refractive index	nD20 1.5405
storage temp.	0-6°C
solubility	Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
Water Solubility	1.5 mg l^-1 (20 °C)
form	liquid
color	Colorless to light yellow
Stability	Hygroscopic, Moisture Sensitive
InChIKey	ATROHALUCMTWTB-WYMLVPIESA-N
CAS DataBase Reference	14816-18-3(CAS DataBase Reference)
NIST Chemistry Reference	Phoxim(14816-18-3)
EPA Substance Registry System	Phoxim (14816-18-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06,GHS08,GHS09
Signal word	Danger
Hazard statements	H302-H311-H317-H330-H361f-H410
Precautionary statements	P201-P260-P273-P280-P304+P340+P310-P403+P233
Hazard Codes	Xn;N,N,Xn
Risk Statements	22-50/53-62-43
Safety Statements	36-60-61-46-36/37
RIDADR	UN 2810
WGK Germany	3
RTECS	MD4740000
HazardClass	6.1(b)
PackingGroup	III
HS Code	29269090
Toxicity	LD50 orally in mice: >2000 mg/kg (Vinopal, Fukuto)

Phoxim Chemical Properties,Uses,Production

Description

Phoxim is a light yellow liquid, Solubility in water is 1.5 mg/L (20 ?C). It is readily soluble in most organic solvents and slightly in aliphatic hydrocarbons. Log Kow = 3.38. It is relatively slowly hydrolyzed in aqueous media; DT₅₀ (22 ?C) at pH 4, 7, and 9 is 26.7, 7.2, and 3.1 d, respectively.

Chemical Properties

yellowish oily liquid, Specific gravity: 1.176 (20°C)

Uses

Phoxim is used to control stored product insect pests in silos and barns. It is also used to control household insects such as ants and other public health pests. Agricultural targets include caterpillars and soil insects in maize, vegetables, cotton and potatoes.

Safety Profile

Poison by ingestion. An experimental teratogen. When heated to decomposition it emits very toxic fumes of CN-, NO,, PO,, and SO,. See also NITRILES.

Metabolic pathway

The primary metabolic step in the metabolism of phoxim in most biological systems is hydrolysis to the oxime, which may occur either oxidatively or via oxidative desulfuration followed by hydrolysis of the oxon which is much more hydrolytically labile. Stage II metabolism in plants involves the oxime group of the oxaminophenylacetonitrile moiety being reduced to an amine followed by its conjugation with malonic acid. Phoxim is one of a quite large group of insecticidal organophosphates which generates tetraethyl pyrophosphate and its thio analogues under the influence of light. These are compounds which are very active as acetylcholinesterase inhibitors and highly toxic to mammals.

Metabolism

Phoxim is oxidatively desulfurated to the oxon, which inhibits housefly AChE 270 times as quickly as bovine AChE. In mammals, the oxon is immediately hydrolyzed into diethyl hydrogen phosphate. The direct cleavage of the oxime ester bond of phoxim, the hydrolytic transformation of the nitrile group into carboxyl, and deethylation also contribute to the low mammalian toxicity. Elimination is very quick, 97% of the dose being excreted in the urine and feces in 24 h. Degradation in soils is also very rapid. By photochemical reactions, the thiooxime phosphate isomer, tetraethyl pyrophosphate, and its monothio analog are produced in small amounts on foliage.

Phoxim Preparation Products And Raw materials

Raw materials

Ethanol Chlorine Triethylamine Phosphorus pentasulfide Water

THIOPHOSPHORYL CHLORIDE Benzeneacetonitrile Sodium nitrite Ethanol 95% Diethyl chlorothiophosphate

Methanol Industrial ethanol Ethyl nitrite 2-Cyanobenzyloxime Phosphine crude oil

Sulfuric acid

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Preparation Products

Fenpropathrin+Phoxim,E.C.

Phoxim Suppliers

Global( 229)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
Hebei Mujin Biotechnology Co.,Ltd	+86-13288715578 +86-13288715578	China	12749	58	Inquiry
Qingdao Trust Agri Chemical Co.,Ltd	+86-008615963231493 +86-008613573296305	China	301	58	Inquiry
Capot Chemical Co.,Ltd.	+8613336195806	China	29731	60	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21622	55	Inquiry
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +8618949832763	China	2986	55	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29855	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49732	58	Inquiry
SIMAGCHEM CORP	+86-13806087780	China	17346	58	Inquiry
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	China	34563	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Hebei Mujin Biotechnology Co.,Ltd	58
Qingdao Trust Agri Chemical Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hefei TNJ Chemical Industry Co.,Ltd.	55
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

Phoxim Spectrum

Phoxim(14816-18-3)MS Phoxim(14816-18-3)¹HNMR Phoxim(14816-18-3)¹³CNMR Phoxim(14816-18-3)IR1

14816-18-3(Phoxim)Related Search:

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λ-Cyhalothrin Molosultap Phorate

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Benzoyl cyanide-0-(diethoxyphosphinothioyl)oxime BAYTHION BAYTHION(R) PHOXIM O,O-Diethyl O-(alpha-cyanobenzylideneamino)phosphorothioate O,O-DIETHYL-2-CYANOBENZYLIDENEAMINO-OXOPHOSPHONOTHIOATE 4-Ethoxy-7-phenyl-3,5-dioxa-6-aza-4-phosphaoct-6-ene-8-nitrile 4-sulfide ALPHA-[[(DIETHOXYPHOS-PHINOTHIOYL)OXY]IMINO]BENZENE-ACETONITRILE VOLATON VOLATON(R) OMS 1170 oms1170 (Diethoxy-thiophosphoryloxyimino)-phenyl acetonitrile (diethoxy-thiophosphoryloxyimino)-phenylacetonitrile 2-(Diethoxyphosphinothioyloxyimino)-2-phenylacetonitrile 3,5-Dioxa-6-aza-4-phosphaoct-6-ene-8-nitrile, 4-ethoxy-7-phenyl-, 4-sulfide 3,5-Dioxa-6-aza-4-phospha-oct-6-ene-8-nitrile,4-ethoxy-7-phenyl-,4-sulfide bayer77488 baysra7502 Benzeneacetonitrile, [[(diethoxyphosphinothioyl)oxy]imino]- Benzeneacetonitrile, alpha-[[(diethoxyphosphinothioyl)oxy]imino]- Benzoyl cyanide O-(diethoxyphosphinothioyl)oxime benzoylcyanideo-(diethoxyphosphinothioyl)oxime ENT 27488 ent27488 Glyoxylonitrile, phenyl-, oxime O,O-diethyl phosphorothioate glyoxylonitrile,phenyl-,oxime,o,o-diethylphosphorothioate O,O-Diaethyl-O-(alpha-cyanbenzyliden-amino)-thionphosphat O,O-Diaethyl-O-(alpha-cyano-benzylidenamino)-monothiophosphat O,O-Diethyl alpha-cyanobenzylideneamino-oxyphosphonothioate O,O-Diethyl phosphorothioate, O-ester with phenylglyoxylonitrile oxime O,O-Diethyl-alpha-cyanobenzylidineaminooxyphosphonothiate O,O-Diethyl-O-(.alpha.-cyanobenzylideneamino)thiophosphate O,O-Diethyl-O-(-cyanobenzylideneamino)thiophosphate o,o-diethylphosphorothioate,o-esterwithphenylglyoxylonitrileoxime Phenylglyoxylnitrile oxime O,O-diethyl phosphorothioate Phenylglyoxylonitrile Oxime O,O-diethyl phosphorothioate phenylglyoxylonitrileoximeo,o-diethylphosphorothioate Phoxime Phoxin Sebacil sra7502 Valexon Valexone Volathion Volation Phosphorothioic acid O-(α-cyanobenzylideneamino) O,O-diethyl Phoxim 100mg [14816-18-3] Phoximsolution,100ppm phoxim,Valaxon O,O-Diethyl O-(alpha-cyanobenzylideneamino)phosphorothioate 4-Ethoxy-7-phenyl-3,5-dioxa-6-aza-4-phosphaoct-6-ene-8-nitrile 4-sulfide alpha-[[(Diethoxyphosphinothioyl)oxy]imino]benzeneacetonitrile 4-Ethoxy-7-phenyl-3,5-dioxa-6-aza-4-phosphaoct-6-ene-8-nitril 4-sulfide 4-Ethoxy-7-phenyl-3,5-dioxa-8-aza-4-phospha-oct-6-ene-8-nitrile-4-sulfide 5-dioxa-6-aza-4-phosphaoct-6-ene-8-nitrile,4-ethoxy-7-phenyl-4-sulfide alpha-(((diethoxyphosphinothioyl)oxy)imino)-benzeneacetonitril B 77488 b77488 BAY 5621