Phoxim
![Phoxim Structure](CAS/GIF/14816-18-3.gif)
- CAS No.
- 14816-18-3
- Chemical Name:
- Phoxim
- Synonyms
- Foxim;PHOXIM;Phoxin;b77488;VOLATON;oms1170;Phoxime;Sebacil;sra7502;Valexon
- CBNumber:
- CB2255860
- Molecular Formula:
- C12H15N2O3PS
- Molecular Weight:
- 298.3
- MOL File:
- 14816-18-3.mol
- Modify Date:
- 2024/7/22 17:51:23
Melting point | 5.55°C |
---|---|
Boiling point | bp0.01 102° |
Density | d420 1.176 |
vapor pressure | 2.1×10-3 Pa (20 °C) |
refractive index | nD20 1.5405 |
storage temp. | 0-6°C |
solubility | Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly) |
Water Solubility | 1.5 mg l-1 (20 °C) |
form | liquid |
color | Colorless to light yellow |
Stability | Hygroscopic, Moisture Sensitive |
InChIKey | ATROHALUCMTWTB-WYMLVPIESA-N |
CAS DataBase Reference | 14816-18-3(CAS DataBase Reference) |
NIST Chemistry Reference | Phoxim(14816-18-3) |
EPA Substance Registry System | Phoxim (14816-18-3) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() ![]() GHS06,GHS08,GHS09 |
---|---|
Signal word | Danger |
Hazard statements | H302-H311-H317-H330-H361f-H410 |
Precautionary statements | P201-P260-P273-P280-P304+P340+P310-P403+P233 |
Hazard Codes | Xn;N,N,Xn |
Risk Statements | 22-50/53-62-43 |
Safety Statements | 36-60-61-46-36/37 |
RIDADR | UN 2810 |
WGK Germany | 3 |
RTECS | MD4740000 |
HazardClass | 6.1(b) |
PackingGroup | III |
HS Code | 29269090 |
Toxicity | LD50 orally in mice: >2000 mg/kg (Vinopal, Fukuto) |
Phoxim Chemical Properties,Uses,Production
Description
Phoxim is a light yellow liquid, Solubility in water is 1.5 mg/L (20 ?C). It is readily soluble in most organic solvents and slightly in aliphatic hydrocarbons. Log Kow = 3.38. It is relatively slowly hydrolyzed in aqueous media; DT50 (22 ?C) at pH 4, 7, and 9 is 26.7, 7.2, and 3.1 d, respectively.
Chemical Properties
yellowish oily liquid, Specific gravity: 1.176 (20°C)
Uses
Phoxim is used to control stored product insect pests in silos and barns. It is also used to control household insects such as ants and other public health pests. Agricultural targets include caterpillars and soil insects in maize, vegetables, cotton and potatoes.
Safety Profile
Poison by ingestion. An experimental teratogen. When heated to decomposition it emits very toxic fumes of CN-, NO,, PO,, and SO,. See also NITRILES.
Metabolic pathway
The primary metabolic step in the metabolism of phoxim in most biological systems is hydrolysis to the oxime, which may occur either oxidatively or via oxidative desulfuration followed by hydrolysis of the oxon which is much more hydrolytically labile. Stage II metabolism in plants involves the oxime group of the oxaminophenylacetonitrile moiety being reduced to an amine followed by its conjugation with malonic acid. Phoxim is one of a quite large group of insecticidal organophosphates which generates tetraethyl pyrophosphate and its thio analogues under the influence of light. These are compounds which are very active as acetylcholinesterase inhibitors and highly toxic to mammals.
Metabolism
Phoxim is oxidatively desulfurated to the oxon, which inhibits housefly AChE 270 times as quickly as bovine AChE. In mammals, the oxon is immediately hydrolyzed into diethyl hydrogen phosphate. The direct cleavage of the oxime ester bond of phoxim, the hydrolytic transformation of the nitrile group into carboxyl, and deethylation also contribute to the low mammalian toxicity. Elimination is very quick, 97% of the dose being excreted in the urine and feces in 24 h. Degradation in soils is also very rapid. By photochemical reactions, the thiooxime phosphate isomer, tetraethyl pyrophosphate, and its monothio analog are produced in small amounts on foliage.
Phoxim Preparation Products And Raw materials
Raw materials
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Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12447 | 58 | Inquiry |
Qingdao Trust Agri Chemical Co.,Ltd | +8613573296305 | China | 297 | 58 | Inquiry |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21667 | 55 | Inquiry |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | China | 2989 | 55 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29888 | 58 | Inquiry |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49392 | 58 | Inquiry |
SIMAGCHEM CORP | +86-13806087780 | China | 17367 | 58 | Inquiry |
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