ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Metabolism >IDO inhibitors >NLG919
NLG919
- CAS No.
- 1402836-58-1
- Chemical Name:
- NLG919
- Synonyms
- NLG91;NLG919;CS-820;RG6078;GDC0919;RG 6078;RG-6078;GDC-0919;GDC 0919;NLG919, >=98%
- CBNumber:
- CB22665157
- Molecular Formula:
- C18H22N2O
- Molecular Weight:
- 282.38
- MOL File:
- 1402836-58-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:03:09
| Melting point | 143 - 146°C |
|---|---|
| Boiling point | 524.6±33.0 °C(Predicted) |
| Density | 1.27±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 15 mg/ml) |
| pka | 14.85±0.20(Predicted) |
| form | solid |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
NLG919 Chemical Properties,Uses,Production
Description
(±)-NLG-919 is an indoleamine 2,3-dioxygenase (IDO) pathway inhibitor (Ki = 7 nM; EC50 = 75 nM). (±)-NLG-919 inhibits IDO-induced T cell suppression and restores T cell response during allogenic mixed lymphocyte reactions in vitro (ED50s = 80 and 120 nM, respectively). In vivo, (±)-NLG-919 induces a 95% reduction in tumor volume when administered in conjunction with a pmel-1 T cell vaccine. Formulations containing (±)-NLG-919 are under investigation in clinical trials for treatment of glioblastoma, melanoma, pancreatic, and breast cancers.
Uses
NLG919 is a potent indoleamine-2,3-dioxygenase (IDO) pathway inhibitor and is suitable for the treatment of immunosuppression associated with cancer.
NLG919 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 175)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9337 | 55 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24639 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | China | 13187 | 58 | Inquiry |
1402836-58-1(NLG919)Related Search:
NLG919
1-CYCLOHEXYL-2-(5H-IMIDAZO[5,1-A]ISOINDOL-5-YL)ETHANOL
5H-Imidazo[5,1-a]isoindole-5-ethanol, α-cyclohexyl-
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alpha-Cyclohexyl-5H-imidazo[5,1-a]isoindole-5-ethanol
NLG919, >=98%
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CS-820
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NLG91
RG 6078
RG6078
RG-6078
1402836-58-1
Inhibitor
Inhibitors