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ChemicalBook > Product Catalog >Organic Chemistry >Carboxylic acids and derivatives >Methyl 4-ketocyclohexanecarboxylate

Methyl 4-ketocyclohexanecarboxylate

Methyl 4-ketocyclohexanecarboxylate Structure
CAS No.
6297-22-9
Chemical Name:
Methyl 4-ketocyclohexanecarboxylate
Synonyms
4-OXO-CYCLOHEXANECARBOXYLIC ACID METHYL ESTER;NSC 17321;4-carbomethoxycyclohexanone;4-(Methoxycarbonyl)cyclohexanone;Methyl 4-cyclohexanonecarboxylate;methyl 4-oxocyclohexancarboxylate;Methyl cyclohexanone-4-carboxylate;METHYL 4-KETOCYCLOHEXANECARBOXYLATE;4-CYCLOHEXANE CARBOXYLIC ACID METHYL ESTER;4-Oxocyclohexane-1-carboxylic acid methyl ester
CBNumber:
CB2282868
Molecular Formula:
C8H12O3
Molecular Weight:
156.18
MOL File:
6297-22-9.mol
Modify Date:
2024/1/10 9:17:59
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Methyl 4-ketocyclohexanecarboxylate Properties

Boiling point 96-97 °C(Press: 8.0 Torr)
Density 1.11g/ml
storage temp. Inert atmosphere,Room Temperature
solubility soluble in Chloroform, Methanol
form Oil
color Clear Colourless
InChI InChI=1S/C8H12O3/c1-11-8(10)6-2-4-7(9)5-3-6/h6H,2-5H2,1H3
InChIKey BLYKGTCYDJZLFB-UHFFFAOYSA-N
SMILES C1(C(OC)=O)CCC(=O)CC1

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H227-H315-H319-H335
Precautionary statements  P305+P351+P338
HS Code  2918300090

Methyl 4-ketocyclohexanecarboxylate Chemical Properties,Uses,Production

Uses

Methyl 4-Oxocyclohexanecarboxylate is an intermediate for preparation of imidazobenzazepine derivatives as dual H1/5-HT2A antagonists for treatment of sleep disorders.

Synthesis

The 4-hydroxy methyl ester (4.147 g; 26.21 mmol) was dissolved in 150 mL DCM, and pyridinium chlorochromate (PCC) (8.476 g; 39.32 mmol) was added. The reaction mixture was allowed to stir at room temperature overnight. The reaction mixture was diluted with ether and decanted. Solvents were removed, and the residue was purified by flash column chromatography using 25 percent EtOAc in a hexane mixture as eluent. The product Methyl 4-ketocyclohexanecarboxylate was obtained as a colorless oil.

Methyl 4-ketocyclohexanecarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

4-FORMYL-CYCLOHEXANECARBOXYLIC ACID METHYL ESTER (1r,4r)-methyl 4-formylcyclohexanecarboxylate Cyclohexanecarboxylic acid, 4-amino-, methyl ester (9CI) 4-OXOCYCLOHEXANECARBONYL CHLORIDE methyl 2,3,4,9-tetrahydro-1H-carbazole-3-carboxylate

Methyl 4-ketocyclohexanecarboxylate Suppliers

Global( 154)Suppliers
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ALS INDIA LIFE SCIENCES +91-8977036379 +91-8977036379 Hyderabad, India 1879 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Shanghai Daken Advanced Materials Co.,Ltd +86-371-66670886 China 18623 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32835 60 Inquiry
Accela ChemBio Inc. +1-858-6993322 United States 19673 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49403 58 Inquiry
Supplier Advantage
ALS INDIA LIFE SCIENCES 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
CHEMSWORTH 30
LEAPCHEM CO., LTD. 58
Capot Chemical Co.,Ltd. 60
Shanghai Daken Advanced Materials Co.,Ltd 58
ATK CHEMICAL COMPANY LIMITED 60
Accela ChemBio Inc. 58
CONIER CHEM AND PHARMA LIMITED 58

6297-22-9(Methyl 4-ketocyclohexanecarboxylate)Related Search:

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METHYL 2,2-DIMETHYL-4,6-DIOXOCYCLOHEXANECARBOXYLATE, 97 DIETHYL 4-OXOCYCLOHEXANE-1,1-DICARBOXYLATE Methyl 4-ketocyclohexanecarboxylate
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METHYL 4-KETOCYCLOHEXANECARBOXYLATE Cyclohexanecarboxylic acid, 4-oxo-, methyl ester methyl 4-oxocyclohexancarboxylate 4-Oxocyclohexane-1-carboxylic acid methyl ester 4-OXO-CYCLOHEXANECARBOXYLIC ACID METHYL ESTER 4-CYCLOHEXANE CARBOXYLIC ACID METHYL ESTER Methyl cyclohexanone-4-carboxylate 4-(Methoxycarbonyl)cyclohexanone NSC 17321 4-carbomethoxycyclohexanone Methyl 4-cyclohexanonecarboxylate Cyclohexanecarboxylic acid, 4-oxo-, methyl este 6297-22-9 Drug Intermediates Intermediates Miscellaneous Reagents