DICYCLOMINE HYDROCHLORIDE
- CAS No.
- 67-92-5
- Chemical Name:
- DICYCLOMINE HYDROCHLORIDE
- Synonyms
- DICYCLOMINE HCL;Dicycloverine HCl;dyspas;atumin;Bentyl);mamiesan;oxityl-p;merbentyl;Magesan P;bentomine
- CBNumber:
- CB2285591
- Molecular Formula:
- C19H36ClNO2
- Molecular Weight:
- 345.95
- MOL File:
- 67-92-5.mol
- Modify Date:
- 2023/6/8 9:02:54
| Melting point | 164-166°C |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | H2O: 50 mg/mL |
| form | powder |
| color | off-white |
| BCS Class | 2/4 |
| EPA Substance Registry System | 2-Diethylaminoethyl bicyclohexyl-1-carboxylate hydrochloride (67-92-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DT7350000 | |||||||||
| HS Code | 2922199695 | |||||||||
| Toxicity | LD50 orl-rat: 1290 mg/kg DRUGAY 6,317,82 | |||||||||
| NFPA 704 |
|
DICYCLOMINE HYDROCHLORIDE Chemical Properties,Uses,Production
Description
Dicyclomine is an M1 and M2 muscarinic acetylcholine receptor antagonist (Kis = 3.16 and 44.7 nM, respectively). It inhibits inositol phosphate accumulation induced by the non-selective acetylcholine agonist carbamoylcholine (carbachol; ) in guinea pig cortex (Ki = 12 nM; pA2 = 7.88). Dicyclomine (10 mg/kg, i.v.) inhibits potassium-induced contraction of ileum, colon, and duodenum in anesthetized rats by 21.85, 30.81, and 37.86%, respectively. Formulations containing dicyclomine have been used to treat functional and irritable bowel syndrome and to relieve muscle spasms in the gastrointestinal tract.
Chemical Properties
White Crystalline Powder
Uses
Dicyclomine Hydrochloride can be used as medication to treat gastric diseases.
Definition
ChEBI: The hydrochloride salt of dicyclomine. An anticholinergic, it is used to treat or prevent spasm in the muscles of the gastrointestinal tract, particularly that associated with irritable bowel syndrome.
General Description
Dicyclomine hydrochloride,2-(diethylamino)ethyl bicyclohexyl-1-carboxylatehydrochloride (Bentyl), has some muscarinic receptorsubtype selectivity. It binds more firmly to M1 and M3 thanto M2 and M4 receptors.76Dicyclomine hydrochloride has one eighth of the neurotropicactivity of atropine and approximately twice themusculotropic activity of papaverine. This preparation, firstintroduced in 1950, has minimized the adverse effects associatedwith the atropine-type compounds.
Clinical Use
Dicyclomine Hydrochloride is used for itsspasmolytic effect on various smooth muscle spasms, particularlythose associated with the GI tract. It is also usefulin dysmenorrhea, pylorospasm, and biliary dysfunction.
Safety Profile
Poison by intravenous route.Moderately toxic by ingestion. Human systemic effects byingestion: rigidity, dyspnea, cyanosis. When heated todecomposition it emits very toxic fumes of HCl and NOx.
DICYCLOMINE HYDROCHLORIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Frolic Pharmachem | +919711094561 | Himachal Pradesh, India | 94 | 58 | Inquiry |
| PALAM PHARMA PVT LTD | +91-079-29704644 +91-9825044098 | Ahmedabad, India | 5 | 58 | Inquiry |
| A.B.ENTERPRISES | +91-9223381464 +91-9223381464 | Maharashtra, India | 78 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Shreepati Pharmaceuticals Pvt Ltd | +91-7312432706 +91-7312532647 | Madhya Pradesh, India | 7 | 58 | Inquiry |
| Biofil Chemicals and Pharmaceuticals Limited | +91-7312426700 +91-7312426713 | Madhya Pradesh, India | 12 | 58 | Inquiry |
| Indoco Remedies Ltd | +91-2262871000 +91-2262871000 | Gujarat, India | 27 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| INDOCO REMEDIES LTD | +91-80-6715 0800 | New Delhi, India | 19 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Frolic Pharmachem | 58 |
| PALAM PHARMA PVT LTD | 58 |
| A.B.ENTERPRISES | 58 |
| Ralington Pharma | 58 |
| Shreepati Pharmaceuticals Pvt Ltd | 58 |
| Biofil Chemicals and Pharmaceuticals Limited | 58 |
| Indoco Remedies Ltd | 58 |
| AKASH PHARMA EXPORTS | 58 |
| Pharma Affiliates | 58 |
| INDOCO REMEDIES LTD | 58 |