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Roquinimex

Roquinimex Structure
CAS No.
84088-42-6
Chemical Name:
Roquinimex
Synonyms
FCF89;LS-2616;CS-1231;LINOMIDE;ABR212616;ROQUINIMEX;PNU 212616;Roquinimex(Linomide);N,1-Dimethyl-N-phenyl-2-oxo-4-hydroxy-1,2-dihydroquinoline-3-carboxamide;1,2-Dihydro-4-hydroxy-1,N-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide
CBNumber:
CB2391777
Molecular Formula:
C18H16N2O3
Molecular Weight:
308.33
MOL File:
84088-42-6.mol
Modify Date:
2024/7/2 8:55:03
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Roquinimex Properties

Melting point 200-204°
Boiling point 436.2±45.0 °C(Predicted)
Density 1.357±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility DMSO: 11 mg/mL
pka 4.50±1.00(Predicted)
form solid
color White to off-white
Merck 14,8259

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312a-P330-P501a
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36/37
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
HS Code  2933.49.2600
NFPA 704
0
2 0

Roquinimex price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemicals (India) L0270 Linomide 84088-42-6 10MG ₹8400 2022-05-26 Buy
ALFA India ALF-J65453-MA Linomide 84088-42-6 10mg ₹29820 2022-05-26 Buy
Product number Packaging Price Buy
L0270 10MG ₹8400 Buy
ALF-J65453-MA 10mg ₹29820 Buy

Roquinimex Chemical Properties,Uses,Production

Description

Roquinimex is an immunomodulator with diverse biological activities. In vivo, roquinimex (80 mg/kg) increases the number of myocardial MHC class II-expressing cells, the ratio of cytotoxic to helper T cells, and survival and decreases necrotic lesion area in a mouse model of murine coxsackievirus B3-induced myocarditis. It induces IFN-γ production, reduces TNF-α and IL-1β production, prevents the development of proteinuria, and ameliorates nephritis in a mouse model of chronic graft versus host disease (GVHD). Roquinimex (300 mg/kg) decreases colonic myeloperoxidase (MPO) activity and mucosal damage in a mouse model of colitis induced by dextran sulfate (DSS; ). It also decreases tumor weight and tumor blood flow in a von Hippel-Lindau (VHL) type 2a paraganglioma mouse xenograft model.

Uses

Biological response modifier; immunomodulator.

Biological Activity

Immunomodulator with stimulatory and antitumor properties. Inhibits in vivo apoptosis of T-cells and inhibits angiogenesis in rats in vivo .

Roquinimex Preparation Products And Raw materials

Raw materials

3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-Methyl-2-oxo- methyl 3-(N-methyl-N-phenylamino)-3-oxopropanoate 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-, Methyl ester 1,2-DIHYDRO-4-HYDROXY-1-METHYL-2-OXO-3-QUINOLINECARBOXYLIC ACID ETHYL ESTER N-methylisatoic anhydride
Isatoic Anhydride N-Methylaniline Anthranilic acid
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Preparation Products

Roquinimex Suppliers

Global( 110)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Alfa Aesar 1 800 209 7001 Maharashtra, India 6913 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Supplier Advantage
TCI Chemicals (India) Pvt. Ltd. 58
Alfa Aesar 58
ATK CHEMICAL COMPANY LIMITED 60
CONIER CHEM AND PHARMA LIMITED 58
InvivoChem 58
LEAP CHEM CO., LTD. 58
TargetMol Chemicals Inc. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58

84088-42-6(Roquinimex)Related Search:

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Roquinimex
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N-PHENYLMETHYL-1,2-DIHYDRO-4-HYDROXYL-N,1-DIMETHYL-2-OXO-QUINOLINE-3-CARBOXAMIDE ROQUINIMEX LINOMIDE LS-2616 1,2-DIHYDRO-4-HYDROXY-N,1-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE 1,2-DIHYDRO-4-HYDROXY-N,N-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE 4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide 1,2-Dihydro-4-hydroxy-1,N-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide N,1-Dimethyl-N-phenyl-2-oxo-4-hydroxy-1,2-dihydroquinoline-3-carboxamide PNU 212616 N-phenyl-N-Methyl-1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-quinoline-3-carboxaMide CS-1231 Roquinimex(Linomide) ABR212616 FCF89 3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl- Tumor Necrosis Factor Receptor,FCF-89,TNF Receptor,TNFR,Roquinimex,Inhibitor,ABR-212616,ABR 212616,FCF 89,inhibit 84088-42-6 C18H16N2O3 Cell Signaling and Neuroscience Cell Biology BioChemical Immune System Regulation Immunomodulators and Antibiotics Immune Cell Signaling and Blood Antitumour