Febuprol
- CAS No.
- 3102-00-9
- Chemical Name:
- Febuprol
- Synonyms
- h-33;valbil;k-10033;FEBUPROL;Valbilan;NSC 30151;Febuprol USP/EP/BP;1-butoxy-3-phenoxy-2-propano;1-butoxy-3-phenoxy-2-propanol;2-Propanol, 1-butoxy-3-phenoxy-
- CBNumber:
- CB2400277
- Molecular Formula:
- C13H20O3
- Molecular Weight:
- 224.3
- MOL File:
- 3102-00-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/4 17:34:37
| Melting point | 25°C |
|---|---|
| Boiling point | bp11 165°; bp1.0 125-132° |
| Density | d420 1.027 |
| refractive index | nD20 1.5004 |
| storage temp. | 2-8°C |
| CAS DataBase Reference | 3102-00-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Toxicity | LD50 in mice, rats (mg/kg): 3050, 2370 orally; 436, 400 i.p. (Hofrichter) |
Febuprol Chemical Properties,Uses,Production
Originator
Valbil,Rohm Pharma,W. Germany,1981
Manufacturing Process
Initially, 4.5 g (0.08 mol) pulverized potassium hydroxide was dissolved in
300 ml isopropanol in a 500 ml four-neck flask equipped with stirrer, intensive
cooler, dropping funnel and feed pipe for the gas treatment with nitrogen.
Then, 52.0 g (0.4 mol) n-butylglycidyl ether and 41.4 g (0.44 mol) phenol
was added thereto, whereafter the material was heated to boiling under
nitrogen. The material was stirred, about 8.5 hours, until no glycidyl ether
could be determined, e.g., by gas chromatography.
After the suspension was cooled under nitrogen, the solvent was distilled off
under vacuum. The residue was taken up in 200 ml water and the milky
emulsion extracted exhaustively with ether. From the organic phase, the
excess butylglycidyl ether was extracted with diluted potassium hydroxide
solution. The ether phase was washed neutral with water and the solvent
removed after drying with sodium sulfate. The remaining oily residue was
distilled under vacuum; there was obtained a colorless liquid of BP
123.5°C/0.07 mm. Yield: 81.8 g (91.1% of the theory)
Therapeutic Function
Choleretic
Febuprol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29901 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | China | 992 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49999 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24017 | 58 | Inquiry |
| Shanghai Haohong Scientific Co., Ltd. | 400-400-8210725 | China | 40041 | 58 | Inquiry |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 17691182729 18161915376 | China | 10011 | 58 | Inquiry |
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