METHSUXIMIDE
- CAS No.
- 77-41-8
- Chemical Name:
- METHSUXIMIDE
- Synonyms
- PM 396;Celontin;Petinutin;Mesuximide;Methsuximid;Mesuximidum;Metsuccimide;METHSUXIMIDE;RSYYMethsuximide;Methsuximide (500 mg)
- CBNumber:
- CB2695398
- Molecular Formula:
- C12H13NO2
- Molecular Weight:
- 203.24
- MOL File:
- 77-41-8.mol
- Modify Date:
- 2023/6/8 9:02:35
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H412 | |||||||||
| Precautionary statements | P264-P270-P273-P301+P312-P501 | |||||||||
| HS Code | 2925190100 | |||||||||
| Toxicity | LD50 orally in mice: 0.9 g/kg (Marshall, Vallance) | |||||||||
| NFPA 704 |
|
METHSUXIMIDE Chemical Properties,Uses,Production
Description
Methsuximide is a succinimide that is converted to N-desmethylmethosuximide, a channel blocker that targets low threshold calcium currents. Methsuximide is a substrate of cytochrome P450 (CYP) isoform 2C19 that, in turn, inhibits CYP2C19-mediated metabolism of biguanides. Methsuximide has been shown to have anticonvulsant properties in clinical trials.
Chemical Properties
Light Yellow Oil
Uses
A calcium channel succinimide antiepileptic drug. Anticonvulsant.
Clinical Use
Although methsuximide is less commonly used, it may be indicated for the control of absence seizures refractory to other drugs. Although it does not precipitate tonic-clonic convulsions, it often is combined with phenytoin or phenobarbital when absence seizures coexist with tonic-clonic symptoms. Much of the efficacy of methsuximide is attributed to its desmethyl metabolite. The half-life of methsuximide is between 2.6 and 4.0 hours, but the half-life for N-desmethylsuximide is 25 hours, causing it to accumulate substantially. Concentrations of greater than 40 g/mL may be associated with toxicity. Methsuximide is considered to be more toxic than ethosuximide.
METHSUXIMIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Nuray Chemicals Pvt Ltd | +91-4066616700 +91-8220444745 | Tamil Nadu, India | 49 | 58 | Inquiry |
| Aruvi Labs | +91-8056181939 +91-8056181939 | Tamil Nadu, India | 149 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24639 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | China | 9618 | 58 | Inquiry |
| changzhou huayang technology co., ltd | +8615250961469 | China | 9827 | 58 | Inquiry |