PHENSUXIMIDE
- CAS No.
- 86-34-0
- Chemical Name:
- PHENSUXIMIDE
- Synonyms
- pm334;Lifen;Epimid;Lifene;PM 334;Epimal;Mirotin;Milontin;Milonton;Mirontin
- CBNumber:
- CB3480203
- Molecular Formula:
- C11H11NO2
- Molecular Weight:
- 189.21
- MOL File:
- 86-34-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/8 9:02:58
| Melting point | 71-73° |
|---|---|
| Boiling point | 324.47°C (rough estimate) |
| Density | 1.1596 (rough estimate) |
| refractive index | 1.5012 (estimate) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| pka | -1.86±0.40(Predicted) |
| color | White to Off-White |
| Water Solubility | 4.2g/L(25 ºC) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| HS Code | 2925190100 | |||||||||
| Toxicity | LD50 orally in mice: 960 mg/kg (Chen, Ensor) | |||||||||
| NFPA 704 |
|
PHENSUXIMIDE Chemical Properties,Uses,Production
Description
Phensuximide is an anticonvulsant. It inhibits seizures induced by maximal electroshock (MES) and pentylenetetrazole in mice (ED50s = 112 and 50 mg/kg, respectively). Phensuximide (1.25 mmol/kg, i.p.) induces proteinuria and hematuria in rats. Formulations containing phensuximide have been used in the treatment of petit mal seizures.
Uses
Phensuximide, like ethosuximide, is an anticonvulsant drug used in minor forms of epilepsy.
Clinical Use
Phensuximide occasionally is used for the treatment of absence seizures refractory to other drugs, although it is considered to be less effective than ethosuximide. It is excreted in both urine and bile, and it may cause harmless pink to red discoloration of the urine. It should be used with caution in patients with acute intermittent porphyria.
Purification Methods
Crystallise phensuximide from hot 95% EtOH (m 72-73o). At 25o 1g of the imide dissolves in 1g of *C6H6, 18g of Et2O, 9.5g of EtOH, 5.1g of MeOH and 235g of H2O. [Beilstein 21 II 300, 21 III/IV 5465.]
PHENSUXIMIDE Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 9003 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | China | 48467 | 58 | Inquiry |
| Jinan Jiuli Biotechnology Co. , Ltd. | 14768611851 | China | 2041 | 58 | Inquiry |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 15229059051 | China | 9971 | 58 | Inquiry |
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