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BISINDOLYLMALEIMIDE I HYDROCHLORIDE

BISINDOLYLMALEIMIDE I HYDROCHLORIDE Structure
CAS No.
176504-36-2
Chemical Name:
BISINDOLYLMALEIMIDE I HYDROCHLORIDE
Synonyms
BIS-I HCl;GO-6860 HCl;BIM 1 hydrochloride;GF 109203X hydrochloride >=95%;BisindolylMaleiMide I( Hydrochloride Salt);BisindolylMaleiMide I . hydrochloride [GF-109203K;Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem;3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride;3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione;3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride
CBNumber:
CB2972282
Molecular Formula:
C25H25ClN4O2
Molecular Weight:
448.95
MOL File:
176504-36-2.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:04
Request For Quotation

BISINDOLYLMALEIMIDE I HYDROCHLORIDE Properties

storage temp. 2-8°C
solubility DMF: 10 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
form Orange-red solid
color Orange to red

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P301+P310
WGK Germany  3
HS Code  2933998090

BISINDOLYLMALEIMIDE I HYDROCHLORIDE price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) B6292 GF 109203X hydrochloride ≥95% 176504-36-2 250μG ₹8205.35 2022-06-14 Buy
Sigma-Aldrich(India) B6292 GF 109203X hydrochloride ≥95% 176504-36-2 1MG ₹22299.5 2022-06-14 Buy
Sigma-Aldrich(India) 203291 Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem An enhanced water-soluble form of Bisindolylmaleimide I. 176504-36-2 250μG ₹7070 2022-06-14 Buy
Sigma-Aldrich(India) 203291 Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem An enhanced water-soluble form of Bisindolylmaleimide I. 176504-36-2 1MG ₹20250 2022-06-14 Buy
Product number Packaging Price Buy
B6292 250μG ₹8205.35 Buy
B6292 1MG ₹22299.5 Buy
203291 250μG ₹7070 Buy
203291 1MG ₹20250 Buy

BISINDOLYLMALEIMIDE I HYDROCHLORIDE Chemical Properties,Uses,Production

Description

Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine . It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα, β1, β2, γ, δ, and ε isozymes. BIM I directly inhibits glycogen synthase kinase 3 (GSK3) in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM). It also competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 61 nM.

Uses

GF 109203X hydrochloride has been used to inhibit protein kinase C in human neuroblastoma-derived kelly cells.

General Description

GF 109203X prevents collagen-triggered adenosine and three phosphate (ATP) secretion. It also inhibits collagen and α-thrombin-induced platelet aggregation. It functions as an inhibitor of glycogen synthase kinase-3 (GSK-3). GF 109203X also functions as an anti-inflammatory agent.

BISINDOLYLMALEIMIDE I HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

BISINDOLYLMALEIMIDE I HYDROCHLORIDE Suppliers

Global( 27)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32835 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghaizehan biopharma technology co., Ltd. 021-61350663 13052117465 China 1008 55 Inquiry
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 China 4997 58 Inquiry
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 China 7416 58 Inquiry
Shanghai Maclean Biochemical Technology Co., LTD 021-50706066 15221275939 China 29802 58 Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826 China 48465 58 Inquiry
Taizhou Nanfeng Pharmaceutical Research Institute 18616377689 China 20566 58 Inquiry
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58
Aladdin Scientific 58
Cayman Chemical Company 81
Shanghaizehan biopharma technology co., Ltd. 55
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Shanghai Maclean Biochemical Technology Co., LTD 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58
Taizhou Nanfeng Pharmaceutical Research Institute 58

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BIM 1 hydrochloride 3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride BisindolylMaleiMide I( Hydrochloride Salt) BisindolylMaleiMide I . hydrochloride [GF-109203K 3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem GF 109203X hydrochloride >=95% BIS-I HCl GO-6860 HCl 176504-36-2