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Celastrol

Celastrol Structure
CAS No.
34157-83-0
Chemical Name:
Celastrol
Synonyms
Tripterine;Celastro;TRIPTERIN;NSC70931;Celatrol;CELASTROL;Celasterol;CELASTROL(SH);Celastrol >Celastrol ,98%
CBNumber:
CB7146431
Molecular Formula:
C29H38O4
Molecular Weight:
450.61
MOL File:
34157-83-0.mol
MSDS File:
SDS
Modify Date:
2024/8/13 17:19:14
Request For Quotation

Celastrol Properties

Melting point 219-230°C
Boiling point 645.7±55.0 °C(Predicted)
Density 1.2
storage temp. -20°C
solubility DMSO: >10mg/mL
pka 4.78±0.70(Predicted)
form solid
color red
λmax 424nm(MeOH)(lit.)
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey KQJSQWZMSAGSHN-JJWQIEBTSA-N
LogP 7.080 (est)
CAS DataBase Reference 34157-83-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  45-24/25
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  2
RTECS  YJ7900000
HS Code  29189900
NFPA 704
0
4 0

Celastrol price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) C0869 Celastrol ≥98% (HPLC), solid 34157-83-0 10MG ₹20556.68 2022-06-14 Buy
Sigma-Aldrich(India) C0869 Celastrol ≥98% (HPLC), solid 34157-83-0 50MG ₹81772.05 2022-06-14 Buy
TCI Chemicals (India) C2737 Celastrol 34157-83-0 25MG ₹24400 2022-05-26 Buy
Product number Packaging Price Buy
C0869 10MG ₹20556.68 Buy
C0869 50MG ₹81772.05 Buy
C2737 25MG ₹24400 Buy

Celastrol Chemical Properties,Uses,Production

Chemical Properties

Orange Red Solid

Uses

Celastrol is an antioxidant natural product which inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies. Celastrol also has been shown to have the power to kill tumor cells and can work as an anticarcinogen. It is also a leptin sensitizer with the potential to reduce weight in obesity.

Uses

An antioxidant natural product Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be

Definition

ChEBI: A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. otently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biological Activity

Antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF- α -induced NF κ B activation. Also shown to inhibit topoisomerase II activity in vitro (IC 50 = 7.41 μ M).

Celastrol Preparation Products And Raw materials

Raw materials

Preparation Products

Celastrol Suppliers

Global( 399)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
Cip Global (India) +91 22 2875 5200 Mumbai, India 81 58 Inquiry
Chengdu GLP biotechnology Co Ltd 028-87075086 13350802083 CHINA 1824 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-029-81138252 +86-18789408387 China 3957 58 Inquiry
Hebei Chuanghai Biotechnology Co,.LTD +86-13131129325 China 5867 58 Inquiry
Chongqing Zhihe Biopharmaceutical Co., Ltd. +8618580541567 China 303 58 Inquiry
Henan Fengda Chemical Co., Ltd +86-371-86557731 +86-13613820652 China 20294 58 Inquiry
Hebei Zhuanglai Chemical Trading Co.,Ltd +8613343047651 China 3002 58 Inquiry
Hebei Shengyang Water Conservancy Engineering Co., Ltd. +8615373025980 China 873 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
TCI Chemicals (India) Pvt. Ltd. 58
Cip Global (India) 58
Chengdu GLP biotechnology Co Ltd 58
Shaanxi Dideu Medichem Co. Ltd 58
Hebei Chuanghai Biotechnology Co,.LTD 58
Chongqing Zhihe Biopharmaceutical Co., Ltd. 58
Henan Fengda Chemical Co., Ltd 58
Hebei Zhuanglai Chemical Trading Co.,Ltd 58
Hebei Shengyang Water Conservancy Engineering Co., Ltd. 58

Celastrol Spectrum

Celastrol(34157-83-0)1HNMR

34157-83-0(Celastrol)Related Search:

Triptonide DanshenP.E Hypericin Schisandrin A WILFORLIDE A
BIX 01294 Chlorphenamine maleate Ellagic acid Myricetin A 769662
Veliparib Triptolide CHLOROPHOSPHONAZO III CHARANTIN(NEW)(P) alpha-Terpinene
Celastrol-methylether Celastrol Celastrol, Celastrus scandens
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(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oicacid Celastrol ,98% (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid 10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydro-picene-2-carboxylic acid 3-Hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid Celastrol(Tripterine) NSC70931 (2r,4as,6as,6ar,14as,14br)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid 3-HYDROXY-9BETA,13ALPHA-DIMETHYL-2-OXO-24,25,26-TRINOROLEANA-1(10),3,5,7-TETRAEN-29-OIC ACID 3-HYDROXY-24-NOR-2-OXO-1(10),3,5,7-FRIEDELATETRAEN-29-OIC ACID 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oicacid, 3-hydroxy-9,13-dimethyl-2-oxo-, (9β,13α,14β,20α)- (9,13a,14,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic Acid 3-Hydroxy-2-oxo- 24-nor-D:A-friedooleana-1(10),3,5,7-tetraen-29-oic Acid CELASTROL(SH) CELASTROL Celastrol (Tripterin) CELASTROL(P)(PLEASE CALL) (20R)-3-Hydroxy-2-oxo-24-nor-D:A-friedoolean-1(10),3,5,7-tetren-29-oic acid 2-Oxo-3-hydroxy-24-norfriedela-1(10),3,5,7-tetraene-29-oic acid 2-Oxo-3-hydroxy-24-norfriedelane-1(10),3,5,7-tetraene-29-oic acid Celasterol Celastrol, 98%, Protease inbibitor Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem good price Celastrol 34157-83-0 Factory Provide Pure Natural 98% Celastrol Powder 34157-83-0 10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid Celastrol > Celatrol (2S,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid Celastrol USP/EP/BP Celastrol (NSC 70931) Celastrol tripterine estratto (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid,3-hydroxy-9,13-dimethyl-2-oxo-, (9b,13a,14b,20a)- TRIPTERIN Tripterine Celastro (2r,4as,6as,6ar,14as,14br)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylicacid (9,13a,14,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen- 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oicacid,3-hydroxy-9,13-dimethyl-2-oxo-,(9β,13α,14β,20α)- 34157-83-0 C29H38O4 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract ProteasomeInhibitors Natural Anti-cancer Medical Materials and It's Derivatives Miscellaneous Natural Products Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Steroids 34157-83-0