Celastrol
![Celastrol Structure](CAS/GIF/34157-83-0.gif)
- CAS No.
- 34157-83-0
- Chemical Name:
- Celastrol
- Synonyms
- Tripterine;Celastro;TRIPTERIN;NSC70931;Celatrol;CELASTROL;Celasterol;CELASTROL(SH);Celastrol >Celastrol ,98%
- CBNumber:
- CB7146431
- Molecular Formula:
- C29H38O4
- Molecular Weight:
- 450.61
- MOL File:
- 34157-83-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/13 17:19:14
Melting point | 219-230°C |
---|---|
Boiling point | 645.7±55.0 °C(Predicted) |
Density | 1.2 |
storage temp. | -20°C |
solubility | DMSO: >10mg/mL |
pka | 4.78±0.70(Predicted) |
form | solid |
color | red |
λmax | 424nm(MeOH)(lit.) |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
InChIKey | KQJSQWZMSAGSHN-JJWQIEBTSA-N |
LogP | 7.080 (est) |
CAS DataBase Reference | 34157-83-0(CAS DataBase Reference) |
Celastrol price More Price(3)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | C0869 | Celastrol ≥98% (HPLC), solid | 34157-83-0 | 10MG | ₹20556.68 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | C0869 | Celastrol ≥98% (HPLC), solid | 34157-83-0 | 50MG | ₹81772.05 | 2022-06-14 | Buy |
TCI Chemicals (India) | C2737 | Celastrol | 34157-83-0 | 25MG | ₹24400 | 2022-05-26 | Buy |
Celastrol Chemical Properties,Uses,Production
Chemical Properties
Orange Red Solid
Uses
Celastrol is an antioxidant natural product which inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies. Celastrol also has been shown to have the power to kill tumor cells and can work as an anticarcinogen. It is also a leptin sensitizer with the potential to reduce weight in obesity.
Uses
An antioxidant natural product Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be
Definition
ChEBI: A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. otently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biological Activity
Antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF- α -induced NF κ B activation. Also shown to inhibit topoisomerase II activity in vitro (IC 50 = 7.41 μ M).
Celastrol Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
Cip Global (India) | +91 22 2875 5200 | Mumbai, India | 81 | 58 | Inquiry |
Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | CHINA | 1824 | 58 | Inquiry |
Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | China | 3957 | 58 | Inquiry |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | China | 5867 | 58 | Inquiry |
Chongqing Zhihe Biopharmaceutical Co., Ltd. | +8618580541567 | China | 303 | 58 | Inquiry |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20294 | 58 | Inquiry |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | China | 3002 | 58 | Inquiry |
Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 | China | 873 | 58 | Inquiry |