Methylthiouracil
- CAS No.
- 56-04-2
- Chemical Name:
- Methylthiouracil
- Synonyms
- MZU;Mtu;Thyril;Alkiron;Basecil;Muracil;Muracin;Orcanon;Thioryl;Thiuryl
- CBNumber:
- CB3108758
- Molecular Formula:
- C5H6N2OS
- Molecular Weight:
- 142.18
- MOL File:
- 56-04-2.mol
- Modify Date:
- 2023/8/17 18:11:45
| Melting point | ~330 °C (dec.)(lit.) |
|---|---|
| Density | 1.291 (estimate) |
| refractive index | 1.6430 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Heated), Methanol (Slightly, Heated) |
| form | Liquid |
| pka | pKa 8.2 (Uncertain) |
| color | Clear colorless to yellow |
| Water Solubility | INSOLUBLE |
| Merck | 14,6128 |
| BRN | 115648 |
| Stability | Incompatible with strong oxidizing agents, iodine, metals. |
| InChIKey | HWGBHCRJGXAGEU-UHFFFAOYSA-N |
| CAS DataBase Reference | 56-04-2(CAS DataBase Reference) |
| IARC | 2B (Vol. Sup 7, 79) 2001 |
| NIST Chemistry Reference | 6-Methyl-2-thiouracil(56-04-2) |
| EPA Substance Registry System | Methylthiouracil (56-04-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317 | |||||||||
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P362+P364 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-40 | |||||||||
| Safety Statements | 36/37-45 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | YR0875000 | |||||||||
| Hazard Note | Irritant/Possible Carcinogen | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29335995 | |||||||||
| Toxicity | MLD in rabbits (mg/kg): 2486 orally (Simon) | |||||||||
| NFPA 704 |
|
Methylthiouracil price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 69400 | 6-Methyl-2-thiouracil purum, ≥98.0% S basis (elemental analysis) | 56-04-2 | 100G | ₹3853.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 69400 | 6-Methyl-2-thiouracil purum, ≥98.0% S basis (elemental analysis) | 56-04-2 | 500G | ₹10178.7 | 2022-06-14 | Buy |
| ALFA India | ALF-A17982-A1 | 6-Methyl-2-thiouracil, 98% | 56-04-2 | 1kg | ₹14481 | 2022-05-26 | Buy |
| ALFA India | ALF-A17982-30 | 6-Methyl-2-thiouracil, 98% | 56-04-2 | 250g | ₹7226 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M0443 | 6-Methyl-2-thiouracil | 56-04-2 | 25G | ₹2900 | 2022-05-26 | Buy |
Methylthiouracil Chemical Properties,Uses,Production
Chemical Properties
white powder
Uses
6-?Methyl-?2-?thiouracil is a derivative of methylthiouracil (M330710), a competitive inhibitor of Nitric Oxide Synthase (NOS). Potential anti-inflammatory agent.
General Description
White crystalline powder with an odor of onions and a bitter taste. A saturated aqueous solution is neutral or slightly acidic.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Methylthiouracil reacts with strong oxidizing agents. Forms complexes with metals and is oxidized by iodine and other sulfhydryl oxidizing agents .
Fire Hazard
Flash point data for Methylthiouracil are not available. Methylthiouracil is probably combustible.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Human teratogenic and reproductive effects by an unspecified route: developmental abnormalities of the endocrine system and effects on newborn including neonatal measures or effects. Experimental reproductive effects. Used to treat hyperthyroidism. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Purification Methods
Crystallise the thiouracil from a large volume of H2O. Purify it further by dissolving in base, adding charcoal, filtering and acidifying with AcOH. Suspend the wet solid (ca 100g) in boiling H2O (1L), stir and add AcOH (20mL), stir and refrigerate. Collect the product, wash it with cold H2O (4 x 200mL), drain it for several hours then place it in an oven at 70o to constant weight. [IR: Short & Thompson J Chem Soc 168 1952, Foster & Snyder Org Synth Coll Vol IV 638 1063, Beilstein 24 III/IV 1289.]
Methylthiouracil Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| NSR Laboratories Pvt. Ltd. | +91-9866989891 +91-9000457345 | Hyderabad, India | 196 | 58 | Inquiry |
| Sajjan India Limited | 09867870497 | Mumbai, India | 78 | 58 | Inquiry |
| Abintio Bio Sciences. | 91-6302904517 | Hyderabad, India | 18 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Innovative Synthetic Molecules | +91 40-24111684 | Hyderabad, India | 527 | 58 | Inquiry |
| Synventia Pharma Pvt Ltd | +91-9000457345 | New Delhi, India | 62 | 58 | Inquiry |
| Jyoti Chemical Centre | 09594652522 | Mumbai, India | 215 | 58 | Inquiry |
| Oceanic Pharmachem Pvt., Ltd. (OPPL) | 91-22-42128600 | Maharashtra, India | 947 | 58 | Inquiry |
| Dr. Jagath Reddy's Heterocyclics | 91-40-23773841 91-40-65572151 | New Delhi, India | 3886 | 42 | Inquiry |
| VMB Chem Bio Sys Pvt Ltd. | +91 (94) 4037-6301 | New Delhi, India | 15 | 0 | Inquiry |
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