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Tenidap

CAS No.: 120210-48-2

Chemical Name:: Tenidap

Synonyms: TENIDAP;AKOS 91367;TENIDAP USP/EP/BP;CP66248,CP-66248-2;5-Chloro-2，3-dihydro-2-oxo-3-(2-thenoyl)-1H-indole-1-carboxamide;(Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H- indole-1-carboxaMide;(3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H-indole-1-carboxaMide;(3Z)-5-CHLORO-3-[HYDROXY(2-THIENYL)METHYLENE]-2-OXO-2,3-DIHYDRO-1H-INDOLE-1-CARBOXAMIDE;1H-Indole-1-carboxamide, 5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-, (3Z)-

CBNumber:: CB3121977

Molecular Formula:: C14H9ClN2O3S

Molecular Weight:: 320.75

MOL File:: 120210-48-2.mol

MSDS File:: SDS

Modify Date:: 2025/1/27 9:38:02

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Tenidap Properties

Melting point	230° (dec)
Boiling point	538.1±60.0 °C(Predicted)
Density	1.648±0.06 g/cm3(Predicted)
storage temp.	Store at +4°C
solubility	DMSO: soluble1mg/mL, clear (warmed)
form	powder
pka	4.50±1.00(Predicted)
color	faint yellow to dark yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Hazard Codes

Risk Statements

WGK Germany

NFPA 704

	0
2		0

Tenidap price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	PZ0196	Tenidap ≥97% (HPLC)	120210-48-2	5MG	₹12178.13	2022-06-14	Buy
Sigma-Aldrich(India)	PZ0196	Tenidap ≥97% (HPLC)	120210-48-2	25MG	₹49080.55	2022-06-14	Buy

Product number	Packaging	Price	Buy
PZ0196	5MG	₹12178.13	Buy
PZ0196	25MG	₹49080.55	Buy

Tenidap Chemical Properties,Uses,Production

Uses

Tenidap is one of the nonsteroidal antiinflammatory drugs (NSAIDs). Tenidap is an NSAID that preferentially inhibits COX-1. Tenidap inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes.

Biological Activity

NSAID that preferentially inhibits COX-1 (IC 50 values are < 0.03, 1.2 and > 30 μ M for COX-1, COX-2 and 5-lipoxygenase respectively). Inhibits formation of pro-inflammatory arachidonic acid metabolites in isolated human peripheral polymorphonuclear leukocytes. Opener of inward rectifying hK IR 2.3 channel (EC 50 = 402 nM).

Mode of action

Tenidap is an anti-inflammatory agent developed by Pfizer with a unique structure that is different and distinguishable from NSAIDs. The mechanism of action of tenidap is that it has dual inhibitory effects on lipoxygenase and dioxygenase, and has antagonism on interleukin-1 (IL-1).

Tenidap Preparation Products And Raw materials

Raw materials

Formyl chloride Chloral hydrate 4-Methylmorpholine Ethanol Methyl chloroformate

Sodium bicarbonate Hydroxylamine hydrochloride 4-Chloroaniline 1H-Indole-1-carboxylic acid, 5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-, phenyl ester, (3Z)-

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Preparation Products

Tenidap Suppliers

Global( 77)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32159	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	22854	58	Inquiry
AFINE CHEMICALS LIMITED	+86-0571-85134551	China	15349	58	Inquiry
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	China	987	58	Inquiry
Aladdin Scientific		United States	52924	58	Inquiry
RD International Technology Co., Limited	18024082417	China	9266	58	Inquiry
TargetMol Chemicals Inc.	4008200310	China	24642	58	Inquiry
Cayman Chemical Company	(800) 364-9897	United States	6213	81	Inquiry
https://hanhongsci.com/	021-54306202 18917919676	China	29998	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Sinoway Industrial co., ltd.	58
Aladdin Scientific	58
RD International Technology Co., Limited	58
TargetMol Chemicals Inc.	58
Cayman Chemical Company	81
https://hanhongsci.com/	58

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AKOS 91367 5-Chloro-2，3-dihydro-2-oxo-3-(2-thenoyl)-1H-indole-1-carboxamide CP66248,CP-66248-2 (3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H-indole-1-carboxaMide (Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylMethylene)-2-oxo-1H- indole-1-carboxaMide TENIDAP 1H-Indole-1-carboxamide, 5-chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-, (3Z)- TENIDAP USP/EP/BP (3Z)-5-CHLORO-3-[HYDROXY(2-THIENYL)METHYLENE]-2-OXO-2,3-DIHYDRO-1H-INDOLE-1-CARBOXAMIDE 120210-48-2 C14H9N2O3SCl