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Ceftazidime

CAS No.: 78439-06-2

Chemical Name:: Ceftazidime

Synonyms: CEFTAZIDIME PENTAHYDRATE;Kefazim;CEFTAZIME;cazpentahydrate;sn401pentahydrate;gr20263pentahydrate;Ceftazidime USP/EP/BP;Ceftazidime 5-hydrate;Ceftazidieme Pentahydrate;Ceftazidime Pentahydrate, >=99%

CBNumber:: CB3246290

Molecular Formula:: C22H24N6O8S2

Molecular Weight:: 564.59

MOL File:: 78439-06-2.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:06

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Ceftazidime Properties

Melting point	>1500C (dec.)
RTECS	UU2230000
storage temp.	2-8°C
solubility	Sparingly soluble in aqueous solution
pka	pKa 1.8 (Uncertain)
form	Solid
color	White
Stability	Light Sensitive, Moisture Sensitive
CAS DataBase Reference	78439-06-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H317-H334
Precautionary statements	P261-P272-P280-P284-P302+P352-P333+P313
Hazard Codes	Xn
Risk Statements	42/43
Safety Statements	22-36/37-45-37-24
WGK Germany	1
HS Code	29419000

Ceftazidime price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	PHR1847	Ceftazidime Pharmaceutical Secondary Standard; Certified Reference Material	78439-06-2	500MG	₹15144.18	2022-06-14	Buy

Product number	Packaging	Price	Buy
PHR1847	500MG	₹15144.18	Buy

Ceftazidime Chemical Properties,Uses,Production

Description

Ceftazidime is the latest third generation cephalosporin to reach the market. It has one of the broadest spectrums of the cephalosporins, similar in many regards to that of cefotaxime. It is particularly active against Pseudomonas aeruginosa, being perhaps 4-5 times more potent in vitro than moxalactam and cefotaxime.

Chemical Properties

White Solid

Uses

Ceftazidime pentahydrate is an antibacterial agent. It is used especially for Pseudomonas and other gram-negative infections in debilitated patients. It is used in the treatment of patients with infections caused by susceptible strains of organisms in the following diseases: lower respiratory tract infections,skin and skin structure infections, urinary tract infections, bacterial septicemia, bone and joint infections, gynecologic infections, intra abdominal infections (including peritonitis), and central nervous system infections (including meningitis).

Definition

ChEBI: A hydrate that is the pentahydrate of ceftazidime, a cephalosporin having 7beta-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino and 3-pyridinium-1-ylmethyl side-groups.

Antimicrobial activity

Its activity is comparable to that of cefotaxime and ceftizoxime, but it is more active against Ps. aeruginosa, including almost all gentamicin-resistant strains, and Burk. cepacia. It is, however, less active against Staph. aureus. It is stable to a wide range of β-lactamases, but is hydrolyzed by some TEM variants.

Clinical Use

It is used, often combined with an aminoglycoside, to treat a wide range of severe urinary, respiratory and wound infections, mostly due to enterobacteria or Ps. aeruginosa. Reference is made to its use in pneumonia, septicemia, meningitis (especially if caused by Ps. aeruginosa), peritonitis, osteomyelitis, neonatal sepsis, burns and melioidosis. Concern has been expressed at the relative frequency with which failure is associated with superinfection or the emergence of resistance.

Side effects

It is generally well tolerated. Preparations containing arginine have replaced those with sodium carbonate, which causes pain on intramuscular injection. Reactions common to cephalosporins have been observed in some patients, including positive antiglobulin tests without hemolysis, raised liver function test values, eosinophilia, rashes, leukopenia, thrombocytopenia and diarrhea, occasionally associated with toxigenic C. difficile.
Failure of therapy has been associated with superinfection with resistant organisms, including Staph. aureus, enterococci and Candida. Resistance caused by induction of chromosomal β-lactamases may emerge in Ps. aeruginosa, Ser. marcescens or Enterobacter spp.

Ceftazidime Preparation Products And Raw materials

Raw materials

Preparation Products

2-METHOXY-PYRIMIDINE-5-CARBALDEHYDE

Ceftazidime Suppliers

Global( 230)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CHEMXTREE STANDARDS	+919872732255	Punjab, India	96	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Anika International Pvt. Limited	91-11-47289900	Delhi, India	94	58	Inquiry
Maas Pharma Chemicals	+91-9958666224	Delhi, India	1607	58	Inquiry
Clearsynth Labs	91-22-45045900	Maharashtra, India	3889	58	Inquiry
OCEAN TRADING CORPORATION	+91(22) 24921669	New Delhi, India	6211	58	Inquiry
Medilink Pharmachem	+91 (79) 3007-0133	New Delhi, India	424	50	Inquiry
ORCHID PHARMA LIMITED	+91–44–2744 4471/72/73/74/75/76/77/78	New Delhi, India	32	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry

Supplier	Advantage
CHEMXTREE STANDARDS	58
Pharma Affiliates	58
Anika International Pvt. Limited	58
Maas Pharma Chemicals	58
Clearsynth Labs	58
OCEAN TRADING CORPORATION	58
Medilink Pharmachem	50
ORCHID PHARMA LIMITED	58
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58

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1-[[(6r,7r)-7-[[(2z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino] acetyl] amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0] oct-2-en-3-yl]methyl]pyridinum hydroxide inner salt 1-[[(6R,7R)-7-[[(2Z)-(2-AMINO-4-THIAZOLYL)[(1-CARBOXY-1-METHYLETHOXY)IMINO]ACETYL]AMINO]-2-CARBOXY-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-EN-3-YL]METHYL]PYRIDINUM PENTAHYDRATE cazpentahydrate gr20263pentahydrate innersalt,(6r-(6-alpha,7-beta(z)))-droxidpentahydrate sn401pentahydrate CEFTAZIME Kefazim 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinum (6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(1-hydroxy-2-methyl-1-oxopropan-2-yl)oxyiminoacetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Ceftazidime Pentahydrate (300 mg) PyridiniuM,1-[[(6R,7R)-7-[[(2Z)-(2-aMino-4-thiazolyl)[(1-carboxy-1-Methylethoxy)iMino]acetyl]aMino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]Methyl]-,inner salt, hydrate (1:5) 1-[[(6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-[(1-carboxy-1-Methylethoxy)iMino]acetyl]aMino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]Methyl]pyridiniuM Inner Salt Pentahydrate CeftazidiMe Pentahydrate (Contain 1 equivalent of Na2CO3 as stabilizer) Ceftazidime Pentahydrate, >=99% Ceftazidieme Pentahydrate (6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(2-carboxypropan-2-yloxyimino)-1-oxoethyl]amino]-8-oxo-3-(1-pyridin-1-iumylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate pentahydrate Ceftazidime USP/EP/BP Ceftazidime 5-hydrate Ceftazidime for peak identification (Y0001111) Ceftazidime Pentahydrate (1098130) CEFTAZIDIME PENTAHYDRATE (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrate 78439-06-2 78439-02-2 C22H32N6O12S2 C22H22N6O7S2H2O C22H22N6O7S2x5H2O C22H22N6O7S25H2O Antibiotics Antibiotics A-F Antibiotics A to Z BioChemical Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds