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SQ 22,536

SQ 22,536 Structure
CAS No.
17318-31-9
Chemical Name:
SQ 22,536
Synonyms
Ax 100;CS-2551;Nsc 53339;9-THF-Ade;SQ 22,536;SQ 22536;SQ-22536;SQ22,536/Inhibitor;SQ22536 (NSC-53339);SQ22536, 10 mM in DMSO;9-(Tetrahydrofuran-2-yl)
CBNumber:
CB3289950
Molecular Formula:
C9H11N5O
Molecular Weight:
205.22
MOL File:
17318-31-9.mol
MSDS File:
SDS
Modify Date:
2025/1/27 9:38:02
Request For Quotation

SQ 22,536 Properties

Melting point 160-161℃
Boiling point 474.8±55.0 °C(Predicted)
Density 1.70±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility H2O: 21 mg/mL
form solid
pka 3.82±0.10(Predicted)
color white to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  2934.99.9001
NFPA 704
0
2 0

SQ 22,536 price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) S153 SQ 22,536 ≥97% (HPLC), powder 17318-31-9 5MG ₹21541.75 2022-06-14 Buy
Sigma-Aldrich(India) S153 SQ 22,536 ≥97% (HPLC), powder 17318-31-9 25MG ₹82757.13 2022-06-14 Buy
Sigma-Aldrich(India) 568500 SQ 22536 - CAS 17318-31-9 - Calbiochem Cell-permeable adenylate cyclase inhibitor. 17318-31-9 5MG ₹16670.01 2022-06-14 Buy
TCI Chemicals (India) Q0105 SQ 22536 min. 97.0 % 17318-31-9 10MG ₹6300 2022-05-26 Buy
TCI Chemicals (India) Q0105 SQ 22536 min. 97.0 % 17318-31-9 50MG ₹14800 2022-05-26 Buy
Product number Packaging Price Buy
S153 5MG ₹21541.75 Buy
S153 25MG ₹82757.13 Buy
568500 5MG ₹16670.01 Buy
Q0105 10MG ₹6300 Buy
Q0105 50MG ₹14800 Buy

SQ 22,536 Chemical Properties,Uses,Production

Description

SQ 22,536 is an inhibitor of adenylyl cyclase with an IC50 value of 13 μM for inhibition of prostaglandin E1-stimulated increase in cAMP in intact platelets. It has been used to evaluate adenylyl cyclase activity during iloprost-induced vasorelaxation of isolated pulmonary veins or aorta in several research paradigms, inhibiting cAMP elevation at concentrations of 100-300 μM without effecting relaxation.

Uses

SQ 22,536 was used to study the role of adenylate cyclase in differentiation of PC12 cells and in gap junctional intercellular communication in breast cancer cells.

Definition

ChEBI: A nucleoside analogue that is adenine in which the nitrogen at position 9 has been substituted by a tetrahydrofuran-2-yl group. It is an adenylate cyclase inhibitor.

Biological Activity

Inhibitor of adenylyl cyclase (IC 50 = 1.4 μ M). Inhibits PGE 1 -stimulated increases in cAMP levels in intact human platelets.

SQ 22,536 Preparation Products And Raw materials

Raw materials

Preparation Products

SQ 22,536 Suppliers

Global( 136)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6768 58 Inquiry
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 China 29730 60 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 33024 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32159 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
Labnetwork lnc. +86-27-50766799 +8618062016861 China 19987 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
Nanjing Doge Biomedical Technology Co., Ltd +86-25-58227606 +86-15305155328 China 4128 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24727 58 Inquiry
Supplier Advantage
A.J Chemicals 58
TCI Chemicals (India) Pvt. Ltd. 58
Capot Chemical Co.,Ltd. 60
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58
Zhejiang J&C Biological Technology Co.,Limited 58
Labnetwork lnc. 58
InvivoChem 58
Nanjing Doge Biomedical Technology Co., Ltd 58
LEAP CHEM CO., LTD. 58

SQ 22,536 Spectrum

SQ 22,536(17318-31-9)1HNMR

17318-31-9(SQ 22,536)Related Search:

Cyclic AMP 5'-IODO-5'-DEOXYADENOSINE ADENOSINE-2':3'-CYCLIC MONOPHOSPHATE, SODIUM SALT 2'-Deoxyadenosine monohydrate 8-BROMOADENOSINE
3'-ADENYLIC ACID N6-ISOPENTENYLADENOSINE-D6 2',3'-O-Isopropylideneadenosine 5'-Tosyladenosine 2-Chloroadenosine
2'-Deoxyadenosine 5'-phosphate Vidarabine Adenosine 5'-monophosphate monohydrate Bucladesine sodium N6-BENZYLADENOSINE
N6-Benzoyl-2'-deoxyadenosine 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE 5'-ACETYL-2',3'-ISOPROPYLIDENEADENOSINE
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9-(2-tetrahydrofuryl)adenine SQ 22,536 ADENYLATE CYCLASE INH 9-(Tetrahydro-2-furynal)-9H-purin-6-amine SQ22,536/Inhibitor 9-(Tetrahydro-2-furanyl)-9H-purin-6-amine, 9-THF-Ade 6-Amino-9-[(tetrahydrofuran)-2-yl]-9H-purine 9-(Tetrahydrofuran-2-yl)-9H-purine-6-amine 6-Amino-9-(tetrahydro-2-furyl)-9H-purine 9-(Tetrahydrofuryl)adenine 9H-Purin-6-amine, 9-(tetrahydro-2-furanyl)- (9ci) Adenine, 9-(tetrahydro-2-furanyl)- (8ci) Adenine, 9-(tetrahydro-2-furyl)- Ax 100 Nsc 53339 9-(Tetrahydrofuran-2-yl)-9H-purin-6-aMine 9H-Purin-6-aMine, 9-(tetrahydro-2-furanyl)- 9-THF-Ade 9-(Tetrahydrofuran-2-yl) SQ 22,536 9-(oxolan-2-yl)-9H-purin-6-amine 9-(TETRAHYDRO-2-FURANYL)-9H-PURIN-6-AMINE 9-(TETRAHYDRO-2-FURANYL)-9H-PURINE-6-AMINE 9-(TETRAHYDRO-2'-FURYL)ADENINE 9-(oxolan-2-yl)purin-6-amine 9-THF-ADE;9-(TETRAHYDROFURAN-2-YL)-9H-PURIN-6-AMINE SQ 22536 - CAS 17318-31-9 - Calbiochem CS-2551 SQ 22536;SQ-22536 Tetrahydrofuryl-9-adenine SQ22536 (NSC-53339) 9-(Tetrahydro-furan-2-yl)-9H-purin-6-ylamine SQ 22536, Non-competitive adenylyl cyclase inhibitor SQ22536, 10 mM in DMSO 17318-31-9 C9H22N5O C9H11N5O G Proteins and Cyclic Nucleotides Cyclic Nucleotide Metabolism Adenylyl Cyclase Inhibitors BioChemical Cell Biology Cell Signaling and Neuroscience