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Plecanatide

Plecanatide Structure
CAS No.
467426-54-6
Chemical Name:
Plecanatide
Synonyms
Trulance;ATCH(1-39);Pukanatide;Plecanatide;Prikanatide;Plecanatide impurity;Plecanatide USP/EP/BP;Plecanatide Impurtiy;ASN-ASP-GLU-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BOND CYS1&CYS3,CYS2&CYS4);L-Leucine, L-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide)
CBNumber:
CB33164713
Molecular Formula:
C65H104N18O26S4
Molecular Weight:
1681.89
MOL File:
467426-54-6.mol
Modify Date:
2024/7/2 8:55:06
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Plecanatide Properties

Boiling point 2120.0±65.0 °C(Predicted)
Density 1.47±0.1 g/cm3(Predicted)
pka 3.61±0.21(Predicted)
form Solid
color White to off-white
InChIKey NSPHQWLKCGGCQR-DLJDZFDSSA-N

Plecanatide Chemical Properties,Uses,Production

Uses

Plecanatide is used in the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation. It works as a laxative by drawing water in to the gastrointestinal tract thereby softening stool and encouraging its natural passage.

Enzyme inhibitor

This uroguanylin analogue (FW = 1681.90 g/mol; CAS 467426-54-6), also known by the codename SP-304, binds to and activates guanylate cyclase-C (GC-C) receptors (EC50 ≈ 0.3 μM) expressed on the epithelial cells lining turn sequentially activates protein kinase G-II and the chloride channel known as the Cystic Fibrosis Transmembrane-conductance Regulator (CFTR) to regulate ion and fluid transport, to promote epithelial cell homeostasis, and to maintain barrier function in the GI mucosa. Plecanatide is a hexadecapeptide that is structurally identical to uroguanylin, except for an glutamate substitution at position-3. Oral treatment with plecanatide at a dose range between 0.05-2.5 mg/kg per day is as effective as once-daily treatment with 5-amino salicylic acid (100 mg/kg) or sulfasalazine (80 mg/kg). Amelioration of colitis by the treatment with plecanatide or dolcanatide was not dose-dependent, most likely due to saturation of available GC-C receptors.

Plecanatide Preparation Products And Raw materials

Raw materials

Preparation Products

Plecanatide Suppliers

Global( 163)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Anthem Biosciences Pvt Ltd +91-8066724000 +91-9900044575 Karnataka, India 38 58 Inquiry
MSN LIFE SCIENCES PRIVATE LTD +91 84523 34200 New Delhi, India 104 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
Apextide Co Ltd +86-15300650552 +86-15300650552 China 71 58 Inquiry
Shanghai Yunao International Trade Co., Ltd +8617621705551 China 265 58 Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd +86-0533-2185556 +8617865335152 China 10978 58 Inquiry
Nantong Guangyuan Chemicl Co,Ltd +undefined17712220823 China 616 58 Inquiry
Supplier Advantage
Anthem Biosciences Pvt Ltd 58
MSN LIFE SCIENCES PRIVATE LTD 58
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Pharma Affiliates 58
AFINE CHEMICALS LIMITED 58
Apextide Co Ltd 58
Shanghai Yunao International Trade Co., Ltd 58
Zibo Hangyu Biotechnology Development Co., Ltd 58
Nantong Guangyuan Chemicl Co,Ltd 58

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Plecanatide ASN-ASP-GLU-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BOND CYS1&CYS3,CYS2&CYS4) Plecanatide Impurtiy L-Leucine, L-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide) Plecanatide impurity Plecanatide USP/EP/BP Prikanatide ATCH(1-39) Trulance (4S)-4-[(2S)-2-[(2S)-2-amino-3-carbamoylpropanamido]-3-carboxypropanamido]-4-{[(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(carbamoylmethyl)-38-{[(1S)-1-carboxy-3-methylbutyl]carbamoyl}-22-(2-carboxyethyl)-32-[(1R)-1-hydroxyethyl]-4-methyl-19-(2-methylpropyl)-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-7,13-bis(propan-2-yl)-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecaazabicyclo[14.13.13]dotetracontan-25-yl]carbamoyl}butanoic acid Pukanatide (S)-5-(((1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(2-Amino-2-oxoethyl)-38-(((S)-1-carboxy-3-methylbutyl)carbamoyl)-22-(2-carboxyethyl)-32-((R)-1-hydroxyethyl)-19-isobutyl-7,13-diisopropyl-4-methyl-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecaazabicyclo[14.13.13]dotetracontan-25-yl)amino)-4-((S)-3-carboxy-2-((S)-2,4-diamino-4-oxobutanamido)propanamido)-5-oxopentanoic acid 467426-54-6 C65H104N18O26S4