Benzocaine
- CAS No.
- 94-09-7
- Chemical Name:
- Benzocaine
- Synonyms
- ETHYL 4-AMINOBENZOATE;Benzocaine base;ethyl aminobenzoate;4-AMINOBENZOIC ACID ETHYL ESTER;Anestezin;Benzocaine, USP, EP;ETHYL P-AMINOBENZOATE;NSC 4688;anesthesin;benzociane
- CBNumber:
- CB1217951
- Molecular Formula:
- C9H11NO2
- Molecular Weight:
- 165.19
- MOL File:
- 94-09-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/13 17:19:14
| Melting point | 88-90 °C |
|---|---|
| Boiling point | 172 °C (12.7517 mmHg) |
| Density | 1.17 |
| refractive index | 1.5600 (estimate) |
| Flash point | 172°C/13mm |
| storage temp. | 2-8°C |
| solubility | alcohol: soluble1 gm in 5 ml |
| form | Crystalline Powder |
| pka | 2.5(at 25℃) |
| color | White |
| Odor | odorless |
| Water Solubility | Soluble in ethanol, chloroform, ethyl ether and dilute acids. Sparingly soluble in water |
| Merck | 14,1086 |
| BRN | 638434 |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChIKey | BLFLLBZGZJTVJG-UHFFFAOYSA-N |
| LogP | 1.860 |
| CAS DataBase Reference | 94-09-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzoic acid, 4-amino-, ethyl ester(94-09-7) |
| EPA Substance Registry System | Benzocaine (94-09-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317 | |||||||||
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P362+P364 | |||||||||
| Hazard Codes | Xi,T,F | |||||||||
| Risk Statements | 43-36/37/38-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 22-24/25-37/39-26-24-45-36/37-16-7 | |||||||||
| RIDADR | 3077 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | DG2450000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29224995 | |||||||||
| Toxicity | LD50 oral in rat: 3042mg/kg | |||||||||
| NFPA 704 |
|
Benzocaine price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | E1501 | Benzocaine ≥99% (HPLC) | 94-09-7 | 100G | ₹4611.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1158 | Benzocaine Pharmaceutical Secondary Standard; Certified Reference Material | 94-09-7 | 1G | ₹8356.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E1501 | Benzocaine ≥99% (HPLC) | 94-09-7 | 500G | ₹9103.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 112909 | Ethyl 4-aminobenzoate 98% | 94-09-7 | 5G | ₹996.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 112909 | Ethyl 4-aminobenzoate 98% | 94-09-7 | 100G | ₹2035.1 | 2022-06-14 | Buy |
Benzocaine Chemical Properties,Uses,Production
Description
Benzocaine (ethyl p-aminobenzoate) is used topically by itself or in combination with menthol or
phenol in nonprescription dosage forms such as gels, creams, ointments, lotions, aerosols, and
lozenges to relieve pain or irritation caused by such conditions as sunburn, insect bites,
toothache, teething, cold sores or canker sores in or around the mouth, and fever blisters.
Benzocaine is a lipophilic local anesthetic agent with a short duration of action.
Like most amino ester-type local anesthetics, it is easily hydrolyzed by plasma cholinesterase.
Because of its low pKa, however, it is un-ionized under most physiological conditions and, therefore, can only bind
to the lipid side of the local anesthetic receptor. It also can easily cross membranes
into systemic circulation to cause systemic toxicities. Furthermore, being a PABA derivative, it
has similar allergenic properties to procaine and is contraindicated with sulfonamide antibacterial
agents.
Chemical Properties
Benzocaine is a white odourless needle-like crystal, slightly soluble in water and easily soluble in organic solvents. For example: ethanol, chloroform, ether, soluble in almond oil, olive oil.
Uses
Benzocaine is used as an anesthetic (Local and topical) that in products such as burn and sunburn remedies, hemorrhoidal creams, suppositories, creams for treatment of poison ivy, oral and gingival products, sore-throat sprays/lozenges, astringents, appetite suppressants, callus and wart remedies, athlete's-foot remedies, toothache- and denture-irritation products.
Definition
ChEBI: Benzocaine is a benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina. It has a role as a topical anaesthetic, an antipruritic drug, an allergen and a sensitiser. It is a benzoate ester and a substituted aniline.
Biological Functions
Benzocaine is a PABA derivative used primarily for topical application to skin and mucous membranes. Its low aqueous solubility allows it to stay at the site of application for long periods. Its minimal rate of absorption after topical administration is associated with a low incidence of systemic toxicity. Benzocaine is contraindicated in patients with known sensitivity to ester-linked anesthetics or PABA-containing compounds.
General Description
Benzocaine is a unique local anesthetic because it does notcontain a tertiary amine. The pKa of the aromatic amine is 3.5ensuring that benzocaine is uncharged at physiological pH.Because it is uncharged, it is not water soluble but is ideal fortopical applications. The onset of action is within 30 secondsand the duration of drug action is 10 to 15 minutes.
Clinical Use
Benzocaine is used for endoscopy, bronchoscopy, and topicalanesthesia. Benzocaine is available as a 20% solution topicalspray, in a 1% gel for mucous membrane application, and a14% glycerin suspension for topical use in the outer ear.Toxicity to benzocaine can occur when the topical doseexceeds 200 to 300 mg resulting in methemoglobinemia.Infants and children are more susceptible to this and methemoglobinemiahas been reported after benzocaine lubricationof endotracheal tubes and after topical administration to treata painful diaper rash.
Safety Profile
Poison by ingestion and intraperitoneal routes. Human systemic effects by rectal route: methemoglobinemia/carboxyhemoglobinem ia in infants. A skin irritant and a mild sensitizer. Local contact may cause contact dermatitis. Used as a topical anesthetic and as a sun-screening agent. When heated to decomposition it emits highly toxic fumes of NOx. See also ETHYL ALCOHOL and ESTERS
Purification Methods
Crystallise Benzocaine from EtOH/H2O or EtOH (m 93-94o), and dry it in air. [Beilstein 14 H 422, 14 IV 1129.]
Benzocaine Preparation Products And Raw materials
Raw materials
Preparation Products
1of4
chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| NB Healthcare Pvt Ltd | +91 7227055467 | Gujarat, India | 37 | 58 | Inquiry |
| SURYA LIFE SCIENCES LIMITED | +91-2646226290 +91-9428511112 | Gujarat, India | 62 | 58 | Inquiry |
| Anant Pharmaceuticals Pvt Ltd | +91-8550986868 +91-9485998001 | Haryana, India | 461 | 58 | Inquiry |
| REDDY N REDDY PHARMACEUTICALS | +91-9848096759 +91-9848096759 | Hyderabad, India | 1989 | 58 | Inquiry |
| Gonane Pharma | +91-9819380043 +91-9819380043 | NaviMumbai, India | 192 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Dishman Carbogen Amcis Ltd (Dishman Group) | +91-2717420100 +91-8154017093 | Gujarat, India | 90 | 58 | Inquiry |
| Apex Healthcare Limited | +9199825711244 | Gujarat, India | 22 | 58 | Inquiry |
| Chynops Pharma | +919998000404 | Gujarat, India | 39 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| NB Healthcare Pvt Ltd | 58 |
| SURYA LIFE SCIENCES LIMITED | 58 |
| Anant Pharmaceuticals Pvt Ltd | 58 |
| REDDY N REDDY PHARMACEUTICALS | 58 |
| Gonane Pharma | 58 |
| JSK Chemicals | 58 |
| Dishman Carbogen Amcis Ltd (Dishman Group) | 58 |
| Apex Healthcare Limited | 58 |
| Chynops Pharma | 58 |
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