Ethyl cyanoformate
![Ethyl cyanoformate Structure](CAS/GIF/623-49-4.gif)
- CAS No.
- 623-49-4
- Chemical Name:
- Ethyl cyanoformate
- Synonyms
- NSC 65347;C2H5OC(O)CN;cyanoformate;ETHYL CYANOFORMATE;Ethylcyanoformate,99%;ethyl carbonocyanidate;Ethyl cyanoformate 99%;Ethoxycarbonyl Cyanide;Ethyl cyanocarboxylate;Ethyl Cyanoformate >
- CBNumber:
- CB8854001
- Molecular Formula:
- C4H5NO2
- Molecular Weight:
- 99.09
- MOL File:
- 623-49-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/4/23 13:52:06
Boiling point | 115-116 °C (lit.) |
---|---|
Density | 1.003 g/mL at 25 °C (lit.) |
refractive index |
n |
Flash point | 76 °F |
storage temp. | Inert atmosphere,2-8°C |
solubility | Miscible with chloroform and methanol. |
form | Liquid |
Specific Gravity | 1.01 |
color | Clear colorless |
Sensitive | Moisture Sensitive |
BRN | 635955 |
Exposure limits | NIOSH: IDLH 25 mg/m3 |
CAS DataBase Reference | 623-49-4(CAS DataBase Reference) |
NIST Chemistry Reference | NCCOOC2H5(623-49-4) |
EPA Substance Registry System | Carbonocyanidic acid, ethyl ester (623-49-4) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() GHS02,GHS05 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H226-H314 | |||||||||
Precautionary statements | P210-P280-P303+P361+P353-P305+P351+P338+P310 | |||||||||
Hazard Codes | T,F | |||||||||
Risk Statements | 10-23/24/25-34-36/37/38 | |||||||||
Safety Statements | 26-36/37/39-45-24/25-16-7/9 | |||||||||
RIDADR | UN 3275 6.1/PG 2 | |||||||||
WGK Germany | 3 | |||||||||
F | 10-19-21 | |||||||||
TSCA | Yes | |||||||||
HazardClass | 6.1 | |||||||||
PackingGroup | II | |||||||||
HS Code | 29269090 | |||||||||
NFPA 704 |
|
Ethyl cyanoformate price More Price(7)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | E18859 | Ethyl cyanoformate 99% | 623-49-4 | 10G | ₹4232.58 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | E18859 | Ethyl cyanoformate 99% | 623-49-4 | 50G | ₹19593.25 | 2022-06-14 | Buy |
ALFA India | ALF-L15777-22 | Ethyl cyanoformate, 99% | 623-49-4 | 100g | ₹32014 | 2022-05-26 | Buy |
ALFA India | ALF-L15777-14 | Ethyl cyanoformate, 99% | 623-49-4 | 25g | ₹11502 | 2022-05-26 | Buy |
ALFA India | ALF-L15777-06 | Ethyl cyanoformate, 99% | 623-49-4 | 5g | ₹2521 | 2022-05-26 | Buy |
Ethyl cyanoformate Chemical Properties,Uses,Production
Chemical Properties
Clear Colourless Liquid
Uses
Ethyl cyanoformate is used as reagent in the preparation of N-substituted amindinoformic acid and ethyl-4-quinazoline -2-carboxylate.
Application
Ethyl cyanoformate can be used as a cyanide source for the cyanation of:
Activated olefins in the presence of a titanium catalyst.
Carbonyl compounds catalyzed by 4-dimethylaminopyridine (DMAP) to yield corresponding cyanohydrin carbonates under metal-free and solvent-free conditions.
Aldehydes and 2,2,2-trifluoroacetophenone catalyzed by N-heterocyclic carbene (NHC) to yield corresponding cyanohydrins ethyl carbonates.
Ethyl cyanoformate is a general cyanating agent. It can be used in the nucleophilic addition of cyanide to carbonyl compounds, oxidative cyanation of tertiary amines and in the synthesis of β-cyano-substituted acrylates from alkynes.
Purification Methods
Dissolve the cyanoformate in Et2O, dry it over Na2SO4, filter, evaporate and distil it [Malachowsky et al. Chem Ber 70 1016 1937, Adickes et al. J Prakt Chem [2] 133 313 1932, Grundmann et al. Justus Liebigs Ann Chem 577 77 1952]. [Beilstein 2 IV 1862.]
Precautions
Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents.
Ethyl cyanoformate Preparation Products And Raw materials
Raw materials
Preparation Products
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GLR Innovations | 58 |
ALS INDIA LIFE SCIENCES | 58 |
Innovative Labs | 58 |
REDDY N REDDY PHARMACEUTICALS | 58 |
CLEARSYNTH LABS LTD. | 58 |
CHEMSWORTH | 30 |
A.J Chemicals | 58 |
ShankuS Bio-Sciences Pvt. Ltd. | 58 |
Reax Chemicals | 58 |
TCI Chemicals (India) Pvt. Ltd. | 58 |
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