Albendazole
- CAS No.
- 54965-21-8
- Chemical Name:
- Albendazole
- Synonyms
- Albendazol;S-oxide;ALBEN;ZENTEL;Atasol;ALBENZA;VALBAZEN;Methyl (6-(propylthio)-1H-benzo[d]imidazol-2-yl)carbamate;[5-(PROPYLTHIO)BENZIMIDAZOL-2-YL]CARBAMIC ACID METHYL ESTER;ZEBEN
- CBNumber:
- CB0241320
- Molecular Formula:
- C12H15N3O2S
- Molecular Weight:
- 265.33
- MOL File:
- 54965-21-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/25 20:04:51
| Melting point | 208-210 °C |
|---|---|
| Density | 1.2561 (rough estimate) |
| refractive index | 1.6740 (estimate) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, freely soluble in anhydrous formic acid, very slightly soluble in methylene chloride, practically insoluble in ethanol (96 per cent). |
| form | Solid |
| pka | 10.72±0.10(Predicted) |
| color | White to Off-White |
| Water Solubility | 0.75mg/L(209 ºC) |
| Merck | 14,210 |
| BCS Class | 4 |
| InChI | InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16) |
| InChIKey | HXHWSAZORRCQMX-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)NC1NC2=CC(SCCC)=CC=C2N=1 |
| CAS DataBase Reference | 54965-21-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H361d-H373-H410 | |||||||||
| Precautionary statements | P202-P260-P273-P280-P308+P313-P391 | |||||||||
| Hazard Codes | T,Xn | |||||||||
| Risk Statements | 61-36/37/38-48/22-63-33 | |||||||||
| Safety Statements | 53-45-37/39-26-36/37-24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | FD1100000 | |||||||||
| HS Code | 29332990 | |||||||||
| NFPA 704 |
|
Albendazole price More Price(2)
Albendazole Chemical Properties,Uses,Production
Chemical Properties
Albendazole occurs as a white to faintly yellowish powder. It is practically insoluble in water and alcohol, very slightly soluble in ether and dichloromethane, but freely soluble in anhydrous formic acid.
Uses
Albendazole is a derivative of benzimidazole, is a drug with a broad antihelmintic spectrum. It exhibits an antihelmintic effect against sensitive cestodes and nematodes by blocking the process of glucose uptake by the parasites, which is expressed in the depletion of glycogen reserves and subsequent reduction in the level of adenosintriphophate. As a result, the parasite stops moving and dies. It is used upon infection of Acaris lumbricoides, Ancylostoma duodenale, Necator americanus, Enterobius vermicularis, and Trichuris trichiura. Synonyms of this drug are SKF 62979 and others.
Indications
Albendazole appears to cause cytoplasmic microtubular degeneration, which in turn impairs vital cellular processes and leads to parasite death.There is some evidence that the drug also inhibits helminth-specific ATP generation by fumarate reductase.
Antimicrobial activity
Albendazole is active against trichostrongyles and exhibits useful activity against tissue-dwelling larvae of Trichinella spiralis, larvae of animal hookworms (causing cutaneous larva migrans) and microfilariae of various filarial species. It also exhibits some activity against cysticercosis and hydatid stages of Echinococcus granulosus and Echinococcus multilocularis. It has been successfully used in infections with the protozoon Giardia lamblia and for microsporidiosis.
General Description
Albendazole occurs as a white crystalline powder that isvirtually insoluble in water. The oral absorption of albendazoleis enhanced by a fatty meal. The drug undergoes rapidand extensive first-pass metabolism to the sulfoxide, whichis the active form in plasma. The elimination half-life ofthe sulfoxide ranges from 10 to 15 hours. Considerable biliaryexcretion and enterohepatic recycling of albendazolesulfoxide occurs. Albendazole is generally well toleratedin single-dose therapy for intestinal nematodes. The highdose,prolonged therapy required for clonorchiasis orechinococcal disease therapy can result in adverse effectssuch as bone marrow depression, elevation of hepatic enzymes,and alopecia.
Mechanism of action
Albendazole is given orally and is poorly and variably absorbed (5%) because of its poor water solubility. Oral bioavailability is increased as much as five times when the drug is given with a fatty meal instead of on an empty stomach. Concurrent treatment with corticosteroids increases plasma concentrations of albendazole. The drug is rapidly metabolized in the liver to an active sulfoxide metabolite.The half life of the metabolites is 8 to 12 hours.
Pharmacokinetics
Albendazole is better absorbed after oral absorption than other benzimidazole carbamates. It is extensively metabolized to the anthelmintically active albendazole sulfoxide, producing plasma concentrations of the metabolite of about 1.3 mg/L 2–5 h after a 400 mg oral dose. The half-life is about 8 h and the major route of excretion is via the bile. Plasma protein binding of the sulfoxide is around 70%.
Clinical Use
Albendazole has a broad spectrum of activity against intestinal nematodes and cestodes, as well as the liver flukes Opisthorchis sinensis, Opisthorchis viverrini, and Clonorchis sinensis. It also has been used successfully against Giardia lamblia. It is widely used throughout the world for the treatment of intestinalnematode infection. It is effective as a single-dose treatmentfor ascariasis, New and Old World hookworm infections,and trichuriasis. Multiple-dose therapy with albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis,and hydatid disease. The effectiveness of albendazole againsttapeworms (cestodes) is generally more variable and lessimpressive. It also is effective in treating cerebral and spinal neurocysticercosis, particularly when given with dexamethasone.Albendazole is recommended for treatment of gnathostomiasis.
Side effects
Various mild intestinal and other upsets usually resolve without treatment. With extended use, as for larval tapeworm infections, hepatic abnormalities or leukopenia may require discontinuation of treatment. In rare cases granulocytopenia, pancytopenia, agranulocytosis or thrombocytopenia may occur. It should not be given during pregnancy since it may cause fetal harm; women should be cautioned against becoming pregnant within a month of completing treatment.
Albendazole Preparation Products And Raw materials
Raw materials
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|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
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| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
| Siflon Drugs | +917780793600 | Hyderabad, India | 12 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| THE MOLECULEZ | 58 |
| Anant Pharmaceuticals Pvt Ltd | 58 |
| Eskay Iodine Pvt Ltd | 58 |
| SNECOFRi Pvt Ltd | 58 |
| CRYSTAL PHARMA | 58 |
| Frolic Pharmachem | 58 |
| KARPSCHEM LABORATORIES | 58 |
| Medi Pharma Drug House | 58 |
| Siflon Drugs | 58 |
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