ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >DNA Methyltransferase Inhibitors >SGI-1027
SGI-1027
- CAS No.
- 1020149-73-8
- Chemical Name:
- SGI-1027
- Synonyms
- CS-1144;SGI-1027;SGI1027; SGI 1027;SGI-1027 USP/EP/BP;DNA Methyltransferase Inhibitor II;N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide;N-[4-[(2-amino-6-methylpyrimidin-4-yl)amino]phenyl]-4-(quinolin-4-ylamino)benzamide;Benzamide, N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)-;N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide SGI-1027;SGI-1027 N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
- CBNumber:
- CB42663344
- Molecular Formula:
- C27H23N7O
- Molecular Weight:
- 461.52
- MOL File:
- 1020149-73-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | >280℃ |
|---|---|
| Density | 1.387±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (up to 35 mg/ml) |
| pka | 13.31±0.70(Predicted) |
| form | powder |
| color | white to light brown |
| Stability | Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
SGI-1027 price More Price(2)
SGI-1027 Chemical Properties,Uses,Production
Uses
SGI-1027 is a quinoline derivative and a potent inhibitor of DNA methyltransferase (DNMT). SGI-1027 can be used as a potential therapeutic agent for the treatment of cancer and other diseases and also as a research tool to investigate the role of DNMTs in epigenetic events.
Biochem/physiol Actions
SGI-1027 is a DNA methyltransferase (DNMT) inhibitor with IC50 values of 6-13 μM for DNMT3B, DNMT3A and DNMT1. SGI-1027 directly inhibits DNMT activity by competing with the cofactor, S-adenosylmethionine (SAM) in the methylation reaction. SGI-1027 treatment of cancer cell lines induced degradation of DNMT1, but not DNMT3A or DNMT3B, and in RKO cells caused re-expression of the silenced tumor supressor genes p16, MLH1 and TIMP3.
SGI-1027 Preparation Products And Raw materials
Raw materials
chevron_left
1of2
chevron_rightPreparation Products
Global( 88)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26216 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | China | 9991 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
1020149-73-8(SGI-1027)Related Search:
N-[4-[(2-amino-6-methylpyrimidin-4-yl)amino]phenyl]-4-(quinolin-4-ylamino)benzamide
SGI-1027
N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
DNA Methyltransferase Inhibitor II
Benzamide, N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)-
N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide SGI-1027
SGI-1027 N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide
CS-1144
SGI1027; SGI 1027
SGI-1027 USP/EP/BP
1020149-73-8
C27H23N7O
Inhibitors