ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >DNA Methyltransferase Inhibitors >RG108
RG108
- CAS No.
- 48208-26-0
- Chemical Name:
- RG108
- Synonyms
- 108;CS-1518;RG108 >98%;RG108/RG-108;RG108 USP/EP/BP;N-Phthalyl-L-tryptophan;N-Phthaloyl-L-tryptophan;N-Phthalyl-L-tryptophan>DNA Methyltransferase Inhibitor;RG-108;RG 108;N-PHTHALYL-L-TRYPTOPHAN
- CBNumber:
- CB0972112
- Molecular Formula:
- C19H14N2O4
- Molecular Weight:
- 334.33
- MOL File:
- 48208-26-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 192-194℃ |
|---|---|
| Boiling point | 606.0±50.0 °C(Predicted) |
| Density | 1.502±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: >10mg/mL |
| pka | 3.62±0.10(Predicted) |
| form | powder |
| color | yellow |
| Sensitive | Light Sensitive |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| CAS DataBase Reference | 48208-26-0 |
RG108 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | R8279 | RG108 ≥98% (HPLC), powder | 48208-26-0 | 10MG | ₹22256.2 | 2022-06-14 | Buy |
| TCI Chemicals (India) | P2023 | N-Phthalyl-L-tryptophan | 48208-26-0 | 50MG | ₹11800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | P2023 | N-Phthalyl-L-tryptophan | 48208-26-0 | 200MG | ₹12000 | 2022-05-26 | Buy |
RG108 Chemical Properties,Uses,Production
Uses
RG108 has been used:
- in reprogramming and increasing cell plasticity of primary multipotent mesenchymal stromal cells (MMSC)
- as an inhibitor of DNA methyltransferase (DNMTi) in human retinal pigment epithelial ARPE-19 cells
- as a DNA methyltransferase inhibitor in C33A2 cells to test its effect on papillomavirus late gene expression (HPV16)
General Description
RG108, a non-nucleoside analog is also called [2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl) propanoic acid.
Biological Activity
Non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes.
RG108 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 145)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 25247 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CHEMSWORTH | 30 |
| A.J Chemicals | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Capot Chemical Co.,Ltd. | 60 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| career henan chemical co | 58 |
| BOC Sciences | 58 |
| TargetMol Chemicals Inc. | 58 |
| Dideu Industries Group Limited | 58 |
| AFINE CHEMICALS LIMITED | 58 |
48208-26-0(RG108)Related Search:
(S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid
RG108/RG-108
(S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid
N-Phthaloyl-L-tryptophan
1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (αS)-
N-Phthaloyl-L-tryptophan
(S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid
DNA Methyltransferase Inhibitor
N-Phthalyl-L-tryptophan
RG108 >98%
RG108/DNA Methyltransferase Inhibitor/N-Phthalyl-L-tryptophan
2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid
CS-1518
RG-108;RG 108;N-PHTHALYL-L-TRYPTOPHAN
N-Phthalyl-L-tryptophan>
108
RG108 USP/EP/BP
1H-Indole-3-propanoicacid, a-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-,(aS)-
48208-26-0
Inhibitors
DNA Methyltransferase Inhibitor
Epigenetics