RG108
RG108
- CAS:
- 48208-26-0
- MF:
- C19H14N2O4
- MW:
- 334.33
Suppliers by country/region
Company Type
Properties
- Melting point:
- 192-194℃
- Boiling point:
- 606.0±50.0 °C(Predicted)
- Density
- 1.502±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: >10mg/mL
- pka
- 3.62±0.10(Predicted)
- form
- powder
- color
- yellow
- Sensitive
- Light Sensitive
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Safety Information
- WGK Germany
- 3
- HS Code
- 2933.99.9701
Use
DNA methylation regulates gene expression in normal and malignant cells. RG-108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro). It significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine. Further, RG-108 inhibits DNA methyltransferase activity by blocking the enzyme active site. Through these actions, RG-108 demethylates and reactivates epigenetically silenced tumor suppressor genes.
1 India supplier list of "RG108"
- Product Name:RG108
- Products Intro:Brand:sigma aldrich | Product Number:R8279 | Purity:≥98%(HPLC),powder
- Company Type: Trader
- Country/Region: Bangalore,INDIA
- Product Name:Rg108 95%
- Products Intro:Brand：Glrinnovations | OriginalID：GLR19.169647
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:N-Phthalyl-L-tryptophan
- Products Intro:Brand:tcichemicals | Product Number:P2023
- Company Type: Reagent
- Country/Region: New Delhi,INDIA
- Product Name:RG108
- Products Intro:Brand:ajchemicals | Product Number:JDH-36117 | Purity:98+%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:RG108
- Products Intro:Brand:chemsworth | Product Number:194479013 | Purity:~97%
- Company Type: Trader
- Country/Region: New Delhi,INDIA
- Product Name:(S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid
- Products Intro:Purity: NLT 98% | Package: 1G;1KG;100KG
- Company Type: Trader
- Country/Region: CHINA
- Main Products: 1159983-30-8,89466-59-1,149739-51-5,104901-79-3,10541-83-0
- Product Name:RG108
- Products Intro:Purity: 98% | Package: 10MG;50MG;100MG,1G,5G,10G.100G
- Company Type: Reagent
- Country/Region: CHINA
- Product Name:RG108/RG-108
- Products Intro:Purity: 98% | Package: 1KG;1USD
- Company Type: Reagent
- Country/Region: CHINA
- Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
$1.00/ 1KG
- Product Name:RG108
- Products Intro:Purity: >98% | Package: 250mg | CustNote: BOC Sciences also provides custom synthesis services for RG108.
- Company Type: Trader
- Country/Region: UNITED STATES
- Product Name:RG108
- Products Intro:Purity: 99.9% | Package: 25kgs/Drum;200kgs/Drum | CustNote: FDA GMP CEP Approved Manufacturer
- Company Type: Trader
- Country/Region: CHINA