Schisandrin
- CAS No.
- 7432-28-2
- Chemical Name:
- Schisandrin
- Synonyms
- SCHISANDROL A;SCHIZANDRIN;SCHIZANDROL A;Schisandrol;SCHIZANDROL;12aR)-;schizandra;SCHISANDRIN;Schisadrol A;Schizandrin std.
- CBNumber:
- CB3334838
- Molecular Formula:
- C24H32O7
- Molecular Weight:
- 432.51
- MOL File:
- 7432-28-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/12/19 16:21:16
| Melting point | 128.5°C |
|---|---|
| Boiling point | 466.17°C (rough estimate) |
| Density | 1.1480 (rough estimate) |
| refractive index | 1.5800 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥13mg/mL |
| form | powder |
| pka | 14.58±0.40(Predicted) |
| color | white to beige |
| optical activity | [α]/D 75 to 95°, c = 1 in methanol |
| InChIKey | YEFOAORQXAOVJQ-UHFFFAOYSA-N |
| LogP | 3.153 (est) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H400 | |||||||||
| Precautionary statements | P301+P312+P330-P273 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-50/53 | |||||||||
| Safety Statements | 60-61 | |||||||||
| RIDADR | UN 3077 9 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29093090 | |||||||||
| NFPA 704 |
|
Schisandrin price More Price(2)
Schisandrin Chemical Properties,Uses,Production
Description
Schizandrin is a dibenzocyclooctadiene lignan and a major component of S. chinensis and has diverse biological activities. It induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells when used at a concentration of 100 μM. Schizandrin (10 and 100 μM) prevents glutamate-induced cytotoxicity, inhibits production of nitric oxide (NO) and reactive oxygen species (ROS), and preserves the mitochondrial membrane potential in isolated rat cortical cells. It reduces apoptosis induced by cisplatin in HK-2 human kidney cells. In vivo, schizandrin (1 and 10 mg/kg, p.o.) reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats. It enhances oxotremorine-induced tremors in mice. Schizandrin (10 mg/kg) reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy.
Uses
Schizandrin may be used in oxidative stress-related cell signaling studies.
Application
Schizandrin is a natural compound that belongs to the group of schisandrins. Schizandrins are a class of compounds with biochemical properties and biological activities, such as anti-inflammatory, antioxidant, and anti-cancer effects. This compound has been shown to have pro-apoptotic properties in a model system. It has also demonstrated the ability to inhibit influenza A virus replication in vitro and protect mice against Listeria monocytogenes infection. It can be used as an inhibitor of gsh-px activity in myocardial infarcts.
Biochem/physiol Actions
Schizandrin is a natural product with several biological properties involved with antioxidant and anti-inflammatory activities. It reduces the formation of ROS, inhibits the mitochondrial pathway of the apoptotic process and oxidative stress. Schizandrin has been reported to have hepatoprotective, antitumor, antiviral, and antiamnesic effects, and has neuroprotective activity against glutamate induced neurotoxicity.
Schisandrin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Sv Agro Food | +91-8048758435 | Delhi, India | 37 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3424 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21675 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29900 | 58 | Inquiry |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | CHINA | 1824 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| SIMAGCHEM CORP | +86-13806087780 | China | 17367 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
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