Riluzole
- CAS No.
- 1744-22-5
- Chemical Name:
- Riluzole
- Synonyms
- RILUTEK;CBI-BB ZERO/001785;6-TRIFLUOROMETHOXYBENZOTHIAZOLE-2-YL-AMINE;6-(Trifluoromethoxy)benzo[d]thiazol-2-amine;uzoL;BF-37;NSC8463;PK 26124;RP-54274;RILUZOLE
- CBNumber:
- CB3353226
- Molecular Formula:
- C8H5F3N2OS
- Molecular Weight:
- 234.2
- MOL File:
- 1744-22-5.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/18 8:51:57
| Melting point | 116-118°C |
|---|---|
| Boiling point | 296.3±50.0 °C(Predicted) |
| Density | 1.572±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥25 mg/mL |
| form | solid |
| pka | 2.96±0.10(Predicted) |
| color | white |
| Merck | 14,8223 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| InChIKey | FTALBRSUTCGOEG-UHFFFAOYSA-N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300 | |||||||||
| Precautionary statements | P301+P310+P330 | |||||||||
| Hazard Codes | T,Xi | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DL2830000 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29342000 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 46 i.p.; 67 orally (Mizoule) | |||||||||
| NFPA 704 |
|
Riluzole price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | R116 | Riluzole solid | 1744-22-5 | 25MG | ₹10013.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | R116 | Riluzole solid | 1744-22-5 | 250MG | ₹65848.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | R116 | Riluzole solid | 1744-22-5 | 500MG | ₹114008.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 557324 | Riluzole - CAS 1744-22-5 - Calbiochem A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. | 1744-22-5 | 50MG | ₹15280 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A2423 | Riluzole | 1744-22-5 | 5G | ₹5100 | 2022-05-26 | Buy |
Riluzole Chemical Properties,Uses,Production
Description
Rilutek was launched in Germany, the UK and US (orphan drug status) for treatment of amyotrophic lateral sclerosis (ALS) and is the first drug approved for this indication. A one step synthesis from 4-(trifluoromethoxy)aniline provides a supply of the compound. The source of its neuroprotective and anticonvulsant activity is not clearly understood. It antagonizes excitatory amino acids and blocks presynaptic release of glutamate, is an antagonist of NMDA-induced acetylcholine release and inhibited glutamate and quisqualate induced increases in cGMP but does not bind to NMDA or Kainic receptors. Rilutek has no affinity for glutamate, GABAbenzodiazepine, glycine and adenosine receptors. It easily crosses the blood brain barrier and depresses glutamatergic neurotransmission, stabilizes voltagedependent Na channels in their inactive form and activates G-protein dependent processes.
Chemical Properties
White Crystalline Solid
Uses
Labeled Riluzole, intended for use as an internal standard for the quantification of Riluzole by GC- or LC-mass spectrometry.
Biological Activity
Novel psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties. Riluzole is able to act as a glutamate release inhibitor, blocks voltage-dependent Na + channels and inhibits GABA uptake by striatal synaptosomes.
Riluzole Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Vardhaman P Golechha | 9704422000 | Telangana, India | 294 | 58 | Inquiry |
| Apotex Pharmachem India Pvt Ltd | +91-8022891034 +91-8022891000 | Karnataka, India | 109 | 58 | Inquiry |
| Glenmark Pharmaceuticals Limited | +912240189999 | Maharashtra, India | 93 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Lakshmi Farmachem | +91-9948795885 +91-9550886476 | Telangana, India | 407 | 58 | Inquiry |
| Aruvi Labs | +91-8056181939 +91-8056181939 | Tamil Nadu, India | 149 | 58 | Inquiry |
| Vachichem | +91-9886704423 +91-9880599557 | Karnataka, India | 72 | 58 | Inquiry |
| Apicore Pharmaceuticals Pvt Ltd | +91-2662267177 +91-2662267166 | Gujarat, India | 181 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Vardhaman P Golechha | 58 |
| Apotex Pharmachem India Pvt Ltd | 58 |
| Glenmark Pharmaceuticals Limited | 58 |
| Hetero Drugs Limited | 58 |
| Lakshmi Farmachem | 58 |
| Aruvi Labs | 58 |
| Vachichem | 58 |
| Apicore Pharmaceuticals Pvt Ltd | 58 |
| Ralington Pharma | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
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