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Caulophylline

CAS No.: 486-86-2

Chemical Name:: Caulophylline

Synonyms: (1r)-l;Caulophyllin;Caulophylline;Methylcytisine;N-METHYLCYTISINE;12-Methylcytisine;12-methyl-cytisin;N-Methylcytisine-RM;Cytisine, 12-methyl-;METHYLCYTISINE, N-(P)

CBNumber:: CB3366194

Molecular Formula:: C12H16N2O

Molecular Weight:: 204.27

MOL File:: 486-86-2.mol

MSDS File:: SDS

Modify Date:: 2025/1/27 9:38:02

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Caulophylline Properties

Melting point	137-139oC
alpha	30D -224° (c = 1.05 in water)
Boiling point	342.77°C (rough estimate)
Density	1.0565 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	-20°C Freezer, Under Inert Atmosphere
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	powder
pka	9.61±0.20(Predicted)
color	White to Off-White
NIST Chemistry Reference	Caulophylline(486-86-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332

Precautionary statements

P261-P271-P280-P301+P312+P330-P302+P352+P312-P304+P340+P312

Hazard Codes

Risk Statements

WGK Germany

RTECS

HA4400000

Toxicity

LD50 in mice (mg/kg): 21 i.v.; 51 i.p. (Barlow, McLeod)

NFPA 704

	0
1		0

Caulophylline price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SMB00353	N-Methylcytisine ≥98% (HPLC)	486-86-2	5MG	₹15815.33	2022-06-14	Buy
Sigma-Aldrich(India)	CDS010442	N-Methylcytisine AldrichCPR	486-86-2	25MG	₹27787.78	2022-06-14	Buy

Product number	Packaging	Price	Buy
SMB00353	5MG	₹15815.33	Buy
CDS010442	25MG	₹27787.78	Buy

Caulophylline Chemical Properties,Uses,Production

Description

This base was first prepared synthetically by Partheil and subsequently discovered in the roots of Caulophyllurn thalictroides L. It is widespread among the Papilionaceae, being found in Baptisia australis, Genista tinctoria, Sophora microphylla, S. tetraptera, Thermopsis lanceolata and T. rhombifolia (Watt.) Richards. It is laevorotatory with [α]²⁰_D - 221 ° (H20) and furnishes the following crystalline salts and derivatives: hydrochloride, m.p. 2S0-SoC (dec.); hydriodide, m.p. 246-7°C (dec.); perchlorate, m.p. 2S4°C (dec.); aurichloride, m.p. 206°C (dec.); picrate, m.p. 230°C; picrolonate, m.p. 224-SoC (dec.) and the methiodide which occurs in two modifications, m.p. 248°C and 267-276°C.

Chemical Properties

Colourless Needles

Uses

N-Methylcytisine (cas# 486-86-2) is a compound useful in organic synthesis.

General Description

N-Methylcytisine is a nicotinic alkaloid found in Caulophyllum thalictroides, also known as blue cohosh.

Hazard

Extremely toxic; cardiotoxic; poisonous.

References

Partheil., Arch. Pharm., 230,448 (1892)
Power, Salway., J. Chem. Soc., 103, 194 (1913)

Caulophylline Preparation Products And Raw materials

Raw materials

Preparation Products

Caulophylline Suppliers

Global( 211)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	33024	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29858	58	Inquiry
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	CHINA	1824	58	Inquiry
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +8618080483897	China	3772	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32202	58	Inquiry
Hubei Ipure Biology Co., Ltd	+8613367258412	China	10244	58	Inquiry
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	China	34563	58	Inquiry
Apeloa Pharmaceutical Co., Ltd.	+86-0571-87635730 +8615858229168	China	1478	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	22854	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
TargetMol Chemicals Inc.	58
Hubei Ipure Biology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Apeloa Pharmaceutical Co., Ltd.	58
Dideu Industries Group Limited	58

Caulophylline Spectrum

Caulophylline(486-86-2)¹HNMR

486-86-2(Caulophylline)Related Search:

1-Methylimidazole CYTISINE N-Methyl-2-pyrrolidone Sodium carboxymethyl cellulose N,N-Dimethylformamide

(-)-SPARTEINE 1-Methylpyrrolidine 2'H-Androst-2-eno[3,2-c]pyrazol-5'(1'H)-one, 17-hydroxy-17-(methyl-d3)-, (5α,17β)- (9CI) L-N-METHYLEPHEDRINE HYDROCHLORIDE Caulophylline hydriodide

(-)-2-[METHYLAMINO]-1-PHENYLPROPANE (-)-N-METHYLEPHEDRINE ANAGYRINE Caulophylline 3-(2-AMINO-ACETYL)-1,2,3,4,5,6-HEXAHYDRO-1,5-METHANO-PYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE

3-(2-AMINO-3-METHYL-BUTYRYL)-1,2,3,4,5,6-HEXAHYDRO-1,5-METHANO-PYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE AKOS 213-126 3-(2-AMINO-4-METHYLSULFANYL-BUTYRYL)-1,2,3,4,5,6-HEXAHYDRO-1,5-METHANO-PYRIDO[1,2-A][1,5]DIAZOCIN-8-ONE

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N-METHYLCYTISINE (1r)-l 1,5-methano-8h-pyrido(1,2a)(1,5)diazocin-8-one,1,2,3,4,5,6-hexahydro-3-methy 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R)- 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R-cis)- 12-methyl-cytisin 12-Methylcytisine Caulophyllin Caulophylline Cytisine, 12-methyl- (1R)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one (1R,5S)-1,2,3,4,5,6-Hexahydro-3-methyl-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one (1R,5S)-3-Methyl-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocine-8-one [1R,(-)]-3-Methyl-1,2,3,4,5,6-hexahydro-1α,5α-methano-8H-pyrido[1,2-a][1,5]diazocine-8-one METHYLCYTISINE, N-(P) N-Methylcytisine AldrichCPR Methylcytisine N-Methylcytisine hydrobromide N-Methylcytisine, 98%, from Sophora flavescens Aiton 1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R,5S)- Caulophylline USP/EP/BP (1R)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]... (1R,5S)-3-Methyl-3,4,5,6-tetrahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-8(2H)-one Caulophylline (N-Methylcytisine) N-Methylcytisine-RM N-Methylcytisine, 10 mM in DMSO N-Methylcytisine 486-86-2 chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). Miscellaneous Reagents standardized herbal extract