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Fluocortolone

Fluocortolone Structure
CAS No.
152-97-6
Chemical Name:
Fluocortolone
Synonyms
flucortolone;FLUORCORTOLONE;SH-742;SH 742;Fluocortolon;FLUOCORTOLONE;Fluorocortolone;Fluocortolone USP/EP/BP;Fluocortolone Impurity 13;methylfluorodehydrocorticosterone
CBNumber:
CB3378252
Molecular Formula:
C22H29FO4
Molecular Weight:
376.46
MOL File:
152-97-6.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:03:04

Fluocortolone Properties

Melting point 113-116°C
alpha D20 +100° (dioxane)
Boiling point 537.4±50.0 °C(Predicted)
Density 1.1001 (estimate)
vapor pressure 0.001Pa at 25℃
storage temp. Refrigerator
solubility Chloroform (Slightly), Dioxane (Slightly), Methanol (Slightly)
form Solid
pka 12.98±0.10(Predicted)
color Pale Yellow to Yellow
Water Solubility 204mg/L at 20℃
LogP 2.3 at 25℃

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08,GHS06
Signal word  Danger
Hazard statements  H360-H301-H372
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P314-P501
NFPA 704
0
2 0

Fluocortolone Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Uses

Fluocortolone is a glucocorticoid used in the treatment of several conditions, including hemorrhoids. Fluocortolone is similar to Fluocortin, but with one less keto group.

Fluocortolone Preparation Products And Raw materials

Raw materials

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Preparation Products

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(6s,8s,9r,10s,11s,13s,14s,16r,17s)-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one 6-alpha-fluoro-11-beta,21-dihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione methylfluorodehydrocorticosterone Fluocortolon Fluorocortolone SH 742 SH-742 (6S,8S,9S,10R,11S,13S,14S,16R,17S)-6-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one (6S,8S,9S,10R,11S,13S,14S,16R,17S)-6-fluoro-11-hydroxy-17-(2-hydroxyethanoyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one (6S,8S,9S,10R,11S,13S,14S,16R,17S)-6-fluoro-17-glycoloyl-11-hydroxy-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one (6α,11β,16α)-6-Fluoro-11,21-dihydroxy-16-Methylpregna-1,4-diene-3,20-dione 16α-Methyl-6α-fluoro-1,4-pregnadien-11β,21-diol-3,20-dione 17alpha-propyl-5alpha-androstan-3-one FLUOCORTOLONE 6-fluoro-11-hydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one Fluocortolone (Fluocortolone Pivalate EPImpurity A) Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16-methyl-, (6α,11β,16α)- Fluocortolone Pivalate EP Impurity A Fluocortolone USP/EP/BP FLUORCORTOLONE flucortolone Fluocortolone Impurity 13 Fluocortolone Pivalate Impurity 1 (Fluocortolone Pivalate EP Impurity A)(Fluocortolone) Fluocortolone Pivalate EP Impurity A (Fluocortolone) 152-97-6 C22H29FO4 Intermediates & Fine Chemicals Pharmaceuticals Steroids