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6(5H)-Phenanthridone

6(5H)-Phenanthridone Structure
CAS No.
1015-89-0
Chemical Name:
6(5H)-Phenanthridone
Synonyms
PJ 97A;NSC 11021;NSC 40943;NSC 61083;WD 99-004344;Phenantridone;PHENANTHRIDONE;PHENANTHRIDINONE;6-Phenanthridone;6-Phenanthridinol
CBNumber:
CB3386736
Molecular Formula:
C13H9NO
Molecular Weight:
195.22
MOL File:
1015-89-0.mol
MSDS File:
SDS
Modify Date:
2023/12/11 17:28:48

6(5H)-Phenanthridone Properties

Melting point 290-292 °C(lit.)
Boiling point 435 °C
Density 1.230±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMF: 1mg/mL; DMF:PBS (pH 7.2) (1:5): 0.16mg/mL
form powder to crystal
pka 13.27±0.20(Predicted)
color White to Light yellow to Light orange
Water Solubility Soluble in DMSO (5 mg/ml). Insoluble in water.
λmax 338nm(EtOH)(lit.)
BRN 140641
CAS DataBase Reference 1015-89-0(CAS DataBase Reference)
NIST Chemistry Reference 6(5H)-phenanthridinone(1015-89-0)
EPA Substance Registry System 6-Phenanthridinone (1015-89-0)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
Safety Statements  22-24/25
WGK Germany  3
RTECS  SG0370000
HS Code  29337900
NFPA 704
1
0 0

6(5H)-Phenanthridone price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 299634 6-(5H)-Phenanthridinone technical grade 1015-89-0 1G ₹2727.9 2022-06-14 Buy
TCI Chemicals (India) P1998 6(5H)-Phenanthridinone 1015-89-0 1G ₹2200 2022-05-26 Buy
TCI Chemicals (India) P1998 6(5H)-Phenanthridinone 1015-89-0 5G ₹7100 2022-05-26 Buy
Product number Packaging Price Buy
299634 1G ₹2727.9 Buy
P1998 1G ₹2200 Buy
P1998 5G ₹7100 Buy

6(5H)-Phenanthridone Chemical Properties,Uses,Production

Uses

6-Phenanthridone is a poly(ADP-ribose) polymerase (PARP) inhibitor with immunosuppressive effects. 6-Phenanthridone has been shown to inhibit concanavalin A-induced lymphocyte proliferation.

Definition

ChEBI: A member of the class of phenanthridines that is phenanthridine with an oxo substituent at position 6. A poly(ADP-ribose) polymerase (PARP) inhibitor, it has been shown to exhibit immunosuppressive activity.

General Description

6-(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose)polymerase (PARP)-1 activity. The ability of 6-(5H)-phenanthridinone to potentiate the effect of ionizing radiation on tumour cells was evaluated. Action of 6-(5H)-phenanthridinone, one of the most potent PARP inhibitor, on RDM4 murine lymphoma cells in culture was evaluated.

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PHENANTHRIDINONE PHENANTHRIDONE 6(5H)-Phenantridinone 6-Phenanthridinol 6-Phenanthridone Phenantridone 2H-BENZ[C]ISOQUINOLIN-1-ONE phenanthridin-6(5H)-one 3,7-DIAMINO-2-METHOXYFLUOREN 98% 6(5H)-PHENANTHRIDINONE 97% 6-PHENANTHRIDINONE 5,6-Dihydrophenanthridin-6-one 5,6-Dihydrophenanthridine-6-one Benzo[c]quinoline-6(5H)-one 5H-phenanthridin-6-one NSC 11021 NSC 40943 NSC 61083 PJ 97A WD 99-004344 phenantridine-6(5H)-one Phenanthridone (misnomer) 6(5H)-PHENANTHRIDINONE 6(5H)-PHENANTHRIDONE 6-(5H)-Phenanthridinone, 97%+ 6(5H)-Phenanthridinone> Quetiapine Impurity 56 1015-89-0 Building Blocks Heterocyclic Building Blocks Others N-Containing Pyrazoles Heterocyclic Building Blocks N-Containing Others Heterocyclic Building Blocks