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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >DNA damage >PARP inhibitors >PJ-34

PJ-34

PJ-34 Structure
CAS No.
344458-15-7
Chemical Name:
PJ-34
Synonyms
PI34;CS-723;PJ34 HC;PJ34(HCL);PJ 34;PJ-34;PJ34 hydrochL;PJ-34 USP/EP/BP;PJ 34 Hydrochloride;PARP Inhibitor VIII, PJ34;PJ34 hydrochloride, >=98%
CBNumber:
CB8972789
Molecular Formula:
C17H17N3O2HCl
Molecular Weight:
0
MOL File:
344458-15-7.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
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PJ-34 Properties

storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility H2O: soluble22mg/mL
form White solid
color white to yellow
Sensitive Light Sensitive & Hygroscopic
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3
HS Code  29339900

PJ-34 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 528150 PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem The PARP Inhibitor VIII, PJ34, also referenced under CAS 344458-15-7, controls the biological activity of PARP. This small molecule/inhibitor is prima 344458-15-7 1MG ₹9490 2022-06-14 Buy
Sigma-Aldrich(India) P4365 PJ-34 hydrochloride hydrate ≥98% (HPLC), powder 344458-15-7 5MG ₹27571.28 2022-06-14 Buy
Sigma-Aldrich(India) 528150 PARP Inhibitor VIII, PJ34 - CAS 344458-15-7 - Calbiochem The PARP Inhibitor VIII, PJ34, also referenced under CAS 344458-15-7, controls the biological activity of PARP. This small molecule/inhibitor is prima 344458-15-7 5MG ₹25060.01 2022-06-14 Buy
Product number Packaging Price Buy
528150 1MG ₹9490 Buy
P4365 5MG ₹27571.28 Buy
528150 5MG ₹25060.01 Buy

PJ-34 Chemical Properties,Uses,Production

Uses

A poly adenosine diphosphate-ribose polymerase inhibitor, attenuates chromate-induced nephrotoxicity. PJ-34 has a lethal effect on breast cancer cells, both in vitro and in vivo, in particular on breast cancer MCF-7.

General Description

A cell-permeable, water-soluble phenanthridinone-derivative that acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC50 = 200 μM). Does not act as an antioxidant at higher concentrations (1 μM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke. Also available as a 20 mM solution in H2O(Cat. No. 528151).

Biological Activity

Potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC 50 = 20 nM). ~ 1000-fold more potent than 3-Aminobenzamide . Protects primary neuronal cells from oxygen-glucose deprivation in vitro and reduces infarct size following focal cerebral ischemia in vivo .

PJ-34 Preparation Products And Raw materials

Raw materials

Preparation Products

PJ-34 Suppliers

Global( 129)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Hangzhou FandaChem Co.,Ltd. 008657128800458; +8615858145714 China 9337 55 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 25247 58 Inquiry
Finetech Industry Limited +86-27-87465837 +8618971612321 China 9624 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10522 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Hangzhou FandaChem Co.,Ltd. 55
ATK CHEMICAL COMPANY LIMITED 60
BOC Sciences 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Finetech Industry Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58

PJ-34 Spectrum

PJ-34(344458-15-7)MS

344458-15-7(PJ-34)Related Search:

4-AMINO-1,8-NAPHTHALIMIDE 3-Aminobenzamide NU1025 PF-01367338 PD 0325901
Erlotinib hydrochloride PD 0332991 HCl ABT 263 Olaparib Rucaparib
DPQ ABT-888 3-(4-CHLORO-PHENYL)-QUINOXALINE-5-CARBOXYLIC ACID AMIDE TIQ-A 6(5H)-Phenanthridone
PJ-34 2'-METHYL-BIPHENYL-2-YLAMINE N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N DIMETHYLACETAMIDE HYDROCHLORIDE HYDRATE
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PJ 34 Hydrochloride N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-acetamidehydrochloride PARP Inhibitor VIII, PJ34 PJ-34 hydrate hydrochloride AcetaMide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(diMethylaMino)-, hydrochloride N-(5,6-Dihydro-6-oxo-2-phenanthridinyl)-2-(diMethylaMino)acetaMide N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide hydrochloride N,N-diMethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetaMide hydrochloride 2-(DiMethylaMino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetaMide hydrochloride PJ34(HCL) Acetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-, hydrochloride (1:1) N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide hydrochloride PJ 34 hydrochloride PJ 34 hydrochloride N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide hydrochloride PJ34 hydrochloride, >=98% 2-(3-(Dimethylamino)-2-oxopropyl)phenanthridin-6(5H)-one hydrochloride n-(6-oxo-5,6-dihydrophenanthridin-2-yl)-(n,n-dimethylamino)acetamide hydrochloride CS-723 PJ 34;PJ-34 PI34 2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide,hydrochloride PJ34 HC PJ34 hydrochL （PJ-34）2-(dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride PJ-34 USP/EP/BP PARP Inhibitor VIII PJ-34 hydrochloride PJ-34 344458-15-7 C17H17N3O2HCl Amines Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals