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NU1025

CAS No.: 90417-38-2

Chemical Name:: NU1025

Synonyms: NU1025;NSC 696807;NU 1025;NU 1025;NU1025 USP/EP/BP;NU1025 (NSC 696807);PARP Inhibitor VI, NU1025;8-Hydroxy-2-methylquinazolin-4(3H);8-HYDROXY-2-METHYLQUINAZOLINE-4-ONE;8-HYDROXY-2-METHYLQUINAZOLIN-4[3H]-ONE;8-HYDROXY-2-METHYL-4(3H)-QUINAZOLINONE

CBNumber:: CB0214872

Molecular Formula:: C9H8N2O2

Molecular Weight:: 176.17

MOL File:: 90417-38-2.mol

MSDS File:: SDS

Modify Date:: 2023/7/12 16:33:30

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NU1025 Properties

Melting point	253-258°C
Boiling point	345.4±44.0 °C(Predicted)
Density	1.42
storage temp.	−20°C
solubility	DMSO: 35 mg/mL, soluble
form	solid
pka	8.68±0.20(Predicted)
color	off-white
CAS DataBase Reference	90417-38-2

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H319

Precautionary statements

P305+P351+P338

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

HS Code

29335990

NFPA 704

	0
2		0

NU1025 price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	N7287	NU-1025 ≥97% (HPLC), solid	90417-38-2	5MG	₹24583.58	2022-06-14	Buy
Sigma-Aldrich(India)	493800	PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem The PARP Inhibitor VI, NU1025, also referenced under CAS 90417-38-2, controls the biological activity of PARP. This small molecule/inhibitor is primar	90417-38-2	5MG	₹20250	2022-06-14	Buy

Product number	Packaging	Price	Buy
N7287	5MG	₹24583.58	Buy
493800	5MG	₹20250	Buy

NU1025 Chemical Properties,Uses,Production

Description

NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC₅₀ = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.

Chemical Properties

Off-White to Pale Yellow Solid

Definition

ChEBI: A member of the class of quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase.

Biological Activity

Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K i and IC 50 values are 48 and 400 nM respectively.

NU1025 Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Nitrogen N,N-Dimethylformamide Acetyl chloride 3-METHOXY-2-NITROBENZOIC ACID

2,3-DICHLORO-5,8-DIHYDROXY-1,4-NAPHTHOQUINONE Boron tribromide Tetrahydrofuran Hydrochloric acid Hydrogen

Methanol Sodium hydroxide Pyridine Isopropyl alcohol Magnesium sulfate

Thionyl chloride Ammonia

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Preparation Products

NU1025 Suppliers

Global( 121)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29898	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	25247	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
Zhengzhou Anbu Chem Co.,Ltd	+86-0371-88006763; +8615988602810	China	3000	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Dideu Industries Group Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Zhengzhou Anbu Chem Co.,Ltd	58

90417-38-2(NU1025)Related Search:

1,5-ISOQUINOLINEDIOL 1(2H)-Isoquinolinone, 5-aMino-, Monohydrochloride 4-AMINO-1,8-NAPHTHALIMIDE 3-Aminobenzamide GSK J4 HCl

LY2409881 4-Hydroxyquinazoline Rucaparib DPQ ABT-888

3-(4-CHLORO-PHENYL)-QUINOXALINE-5-CARBOXYLIC ACID AMIDE TIQ-A 5-Benzoyloxy-1(2H)-isoquinolinone NU1025 2-METHYL-4(3H)-QUINAZOLINONE

Oxazoline 2-METHYL-4(3H)-QUINAZOLINONE 8-methoxy-2-methylquinazolin-4(3H)-one

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NU1025 8-HYDROXY-2-METHYL-4(3H)-QUINAZOLINONE 8-HYDROXY-2-METHYLQUINAZOLIN-4[3H]-ONE 8-HYDROXY-2-METHYLQUINAZOLINE-4-ONE 8-Hydroxy-2-methylquinazoline-4-one ,97% 8-hydroxy-2-methyl-1H-quinazolin-4-one NSC 696807 4(3H)-Quinazolinone, 8-hydroxy-2-Methyl- 8-hydroxy-2-methylquinazolin-4(1H)-one 8-Hydroxy-2-methylquinazolin-4(3H) NU1025 (NSC 696807) PARP Inhibitor VI, NU1025 PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem NU 1025;NU 1025 NU1025 USP/EP/BP 90417-38-2 Kinase/Phosphatase Biology Serine/Threonine Kinase Inhibitors Cyclin-Dependent Kinase (CDK) Cell Biology Cell Signaling and Neuroscience BioChemical All Inhibitors Inhibitors Aromatics