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DPQ

DPQ Structure
CAS No.
129075-73-6
Chemical Name:
DPQ
Synonyms
DPQ;DMEM(Low Glucose);DPQ, PARP-1 inhibitor;PARP Inhibitor III, DPQ;PARP Inhibitor III, DPQ - CAS 129075-73-6 - Calbiochem;3,4-DIHYDRO-5[4-(1-PIPERINDINYL)BUTOXY]-1(2H)-ISOQUINOLINE;3,4-DIHYDRO-5[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINE;5-(4-piperidin-1-ylbutoxy)-3,4-dihydro-2H-isoquinolin-1-one;3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXY]-1(2H)-ISOQUINOLINONE;3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINONE
CBNumber:
CB5126204
Molecular Formula:
C18H26N2O2
Molecular Weight:
302.41
MOL File:
129075-73-6.mol
MSDS File:
SDS
Modify Date:
2025/4/17 18:22:24
Request For Quotation

DPQ Properties

Melting point 107-109°
Boiling point 528.8±50.0 °C(Predicted)
Density 1.096±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: Soluble
form solid
pka 14.54±0.20(Predicted)
color White to off-white
biological source synthetic (organic)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H335-H319-H315
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
NFPA 704
0
2 0

DPQ price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) D5314 DPQ ≥98% (HPLC), solid 129075-73-6 1MG ₹10500.25 2022-06-14 Buy
Sigma-Aldrich(India) D5314 DPQ ≥98% (HPLC), solid 129075-73-6 5MG ₹41903.58 2022-06-14 Buy
Sigma-Aldrich(India) 300270 PARP Inhibitor III, DPQ - CAS 129075-73-6 - Calbiochem The PARP Inhibitor III, DPQ, also referenced under CAS 129075-73-6, controls the biological activity of PARP. This small molecule/inhibitor is primari 129075-73-6 1MG ₹13100 2022-06-14 Buy
Product number Packaging Price Buy
D5314 1MG ₹10500.25 Buy
D5314 5MG ₹41903.58 Buy
300270 1MG ₹13100 Buy

DPQ Chemical Properties,Uses,Production

Description

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. DPQ is a potent inhibitor of PARPs, inhibiting PARP1 with an IC50 value of 40 nM. It is approximately 10-fold less potent against PARP2. DPQ can be used in either cells or in animals.

Uses

DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation.

Biochem/physiol Actions

3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide.

DPQ Preparation Products And Raw materials

Raw materials

Preparation Products

DPQ Suppliers

Global( 119)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
TargetMol Chemicals Inc. United States 38630 58 Inquiry
SUZHOU SENFEIDA CHEMICAL CO.,LTD +86-0512-83500002 +8618501500038 China 26362 58 Inquiry
Aladdin Scientific United States 52924 58 Inquiry
Changsha Fuzhen Biotechnology Co.，LTD 18670069958 13823398779 China 3342 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9835 58 Inquiry
TargetMol Chemicals Inc. 021-021-33632979 15002134094 China 7783 58 Inquiry
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 China 9803 58 Inquiry
Beijing Dongge Boye Biotechnology Co., Ltd. 4008558271 CHINA 6648 58 Inquiry
Shanghai Yiyan Biological Technology Co., Ltd. 400-636-9198 CHINA 3762 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
TargetMol Chemicals Inc. 58
SUZHOU SENFEIDA CHEMICAL CO.,LTD 58
Aladdin Scientific 58
Changsha Fuzhen Biotechnology Co.，LTD 58
RD International Technology Co., Limited 58
TargetMol Chemicals Inc. 58
Shanghai EFE Biological Technology Co., Ltd. 58
Beijing Dongge Boye Biotechnology Co., Ltd. 58
Shanghai Yiyan Biological Technology Co., Ltd. 58

129075-73-6(DPQ)Related Search:

4-AMINO-1,8-NAPHTHALIMIDE 3-Aminobenzamide NU1025 DMEM/F12 medium DMEM medium
4-Hydroxyquinazoline Rucaparib ABT-888 1,5-ISOQUINOLINEDIOL 1(2H)-Isoquinolinone, 5-aMino-, Monohydrochloride
5-Benzoyloxy-1(2H)-isoquinolinone 3-(4-CHLORO-PHENYL)-QUINOXALINE-5-CARBOXYLIC ACID AMIDE TIQ-A 5-METHOXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE DPQ
5-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE 1,2,3,4-TETRAHYDRO-ISOQUINOLIN-5-OL DULBECCO'S MODIFIED EAGLE'S MEDIUM W/L-&
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PARP Inhibitor III, DPQ DPQ 3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXY]-1(2H)-ISOQUINOLINONE 3,4-DIHYDRO-5[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINE 3,4-DIHYDRO-5-[4-(1-PIPERIDINYL)BUTOXYL]-1(2H)-ISOQUINOLINONE 3,4-DIHYDRO-5[4-(1-PIPERINDINYL)BUTOXY]-1(2H)-ISOQUINOLINE 5-[4-(1-PIPERIDINYL)-BUTYLOXY]-1,2,3,4-TETRAHYDROISOQUINOLIN-1-ONE DMEM(Low Glucose) 1(2H)-Isoquinolinone, 3,4-dihydro-5-[4-(1-piperidinyl)butoxy]- PARP Inhibitor III, DPQ - CAS 129075-73-6 - Calbiochem 5-(4-piperidin-1-ylbutoxy)-3,4-dihydro-2H-isoquinolin-1-one DPQ, PARP-1 inhibitor 5-(4-(piperidin-1-yl)butoxy)-3,4-dihydroisoquinolin-1(2H)-one 129075-73-6 BioChemical Apoptosis and Cell Cycle Cell Biology Cell Signaling and Neuroscience PARP Regulators PARP