Desloratadine
- CAS No.
- 100643-71-8
- Chemical Name:
- Desloratadine
- Synonyms
- DESLORATIDINE;Clarinex;Desloratadine Citrate Disodium;descarboethoxyloratadine;Loratadine Related Compound A (15 mg) (8-chloro-6,11-dihydro-11(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b] pyridine);DesL;Allex;AzoMyr;Opulis;Aerius
- CBNumber:
- CB3462564
- Molecular Formula:
- C19H19ClN2
- Molecular Weight:
- 310.82
- MOL File:
- 100643-71-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/21 14:26:55
| Melting point | 150-151°C |
|---|---|
| Boiling point | 467.9±45.0 °C(Predicted) |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >10mg/mL |
| pka | 10.27±0.20(Predicted) |
| form | powder |
| color | White to Light orange to Yellow |
| Merck | 14,2922 |
| BCS Class | 1 |
| InChIKey | JAUOIFJMECXRGI-UHFFFAOYSA-N |
| CAS DataBase Reference | 100643-71-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS08,GHS07,GHS05,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H361-H302-H318-H411 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P280-P305+P351+P338-P310-P201-P202-P281-P308+P313-P405-P501 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DE8011000 | |||||||||
| HS Code | 2933399090 | |||||||||
| NFPA 704 |
|
Desloratadine price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | PHR1680 | Desloratidine Pharmaceutical Secondary Standard; Certified Reference Material | 100643-71-8 | 1G | ₹11961.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D1069 | Desloratadine powder, ≥98% (HPLC) | 100643-71-8 | 10MG | ₹16540.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D1069 | Desloratadine powder, ≥98% (HPLC) | 100643-71-8 | 50MG | ₹61778.28 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D3787 | Desloratadine | 100643-71-8 | 100MG | ₹1800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D3787 | Desloratadine | 100643-71-8 | 1G | ₹8900 | 2022-05-26 | Buy |
Desloratadine Chemical Properties,Uses,Production
Description
Desloratadine is a second generation of tricyclic antihistamine. It is a H1-receptor antagonist which has anti-inflammatory activity. Its affinity to the H1 receptor is higher than most other H1-receptor antagonists. Desloratadine works by blocking a certain natural substance (histamine) which is produced during an allergic reaction. Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system.
Desloratadine is used to treat nasal and non-nasal symptoms (watery eyes, runny nose, itching eyes/nose, sneezing, and itching) of seasonal allergic rhinitis. It is also used to relieve chronic itching caused by hives.
Chemical Properties
Beige Solid
Uses
Desloratadine has been used to test its effect on embryoid body development in in vitro gastrulation model of P19C5 stem cells. It has also been used as an antihistamine mimic in rats and to treat lung cancer (A549) and glioblastoma (U87) cells in various cellular studies.
Indications
Desloratadine (Clarinex) is an active metabolite of loratadine. A 5 mg daily dose has been shown to be effective. There is no evidence that it offers any advantage over loratadine. Fexofenadine (like its parent compound terfenadine) may rarely promote cardiac arrhythmias (24). No significant difference in efficacy has been noted in the nonsedating H1 blockers. Combinations of nonsedating antihistamines in the morning and sedating antihistamines in the evening may be more cost effective than increasing doses of the nonsedating agent.
Definition
ChEBI: Loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis nd chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness.
General Description
Desloratadine, 8-chloro-6,11-dihydro-11-(4-piperdinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine(Clarinex) is a white to off-white powder that is slightlysoluble in water, but very soluble in ethanol and propyleneglycol. It is the proposed active metabolite loratadine and hasa very similar receptor binding and safety profile. It is indicated for the symptomatic relief of pruritus andreduction in the number and size of hives in chronic idiopathicurticaria patients 6 months of age and older and for therelief of the nasal and nonnasal symptoms of perennial allergicrhinitis (in patients 6 months of age and older) and seasonalallergic rhinitis (in patients 2 years of age and older).
Desloratadine is extensively metabolized to 3-hydroxydesloratadine,also an active metabolite, which is subsequentlyglucuronidated . The cytochrome enzymesresponsible for the formation of 3-hydroxydesloratadinehave not been reported. Coadministration ofdesloratadine with CYP3A4 inhibitors results in marginalincreases in plasma concentrations of desloratadine and3-hydroxydesloratadine, but no significant changes in safetyor efficacy. The mean elimination half-life of desloratadineis about 6 hours, and the drug and its metabolites areeliminated in the urine and feces.
References
[1] https://www.drugbank.ca
[2] Raif S. Geha, Eli O. Meltzer (2001) Desloratadine: A new, nonsedating, oral antihistamine, The Journal of Allergy and Clinical Immunology,107, 751-762
Desloratadine Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TAGOOR LABORATORIES PVT LTD | +919700187008 | AndhraPradesh, India | 93 | 58 | Inquiry |
| Cadila Pharmaceuticals Ltd | +91-7069076657 +91-7069076657 | Ahmedabad, India | 54 | 58 | Inquiry |
| Siddhivinayakchemicals | +91-912225190111 +91-9819773074 | Mumbai, India | 42 | 58 | Inquiry |
| Dr. Reddy's Laboratories Ltd | +91-4049002900 +91-4049002900 | Hyderabad, India | 165 | 58 | Inquiry |
| Veer Pharmachem | +91-02645661117 +91-9879471589 | Gujarat, India | 39 | 58 | Inquiry |
| Vadivarhe Speciality Chemicals Limited | +91-9028832204 +91-9028832204 | Maharashtra, India | 38 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| PANCHSHEEL ORGANICS LTD | +91-9821053955 +91-9324201019 | Mumbai, India | 82 | 58 | Inquiry |
| Nivika Chemo Pharma Pvt Ltd | +91-9824176501 +91-9824176501 | Gujarat, India | 15 | 58 | Inquiry |
| Meenaakshi Molecules Pvt Ltd | +91-9121311126 +91-9121311126 | Telangana, India | 45 | 58 | Inquiry |
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