Sieber Linker
- CAS No.
- 3722-51-8
- Chemical Name:
- Sieber Linker
- Synonyms
- HF;3-Hydroxy-9H-xanthen-9-one;Sibur linker;SIEBER LINKER;3-HYDROXYXANTHONE;6-HYDROXY-3-FLUORONE;SALOR-INT L254835-1EA;3-HYDROXY-XANTHEN-9-ONE;SIEBER LINKER, 99% MIN.;3-hydroxy-9H-9-xanthenone
- CBNumber:
- CB3710805
- Molecular Formula:
- C13H8O3
- Molecular Weight:
- 212.2
- MOL File:
- 3722-51-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/11 19:21:31
| Melting point | 243 °C |
|---|---|
| Boiling point | 403.9±24.0 °C(Predicted) |
| Density | 1.395±0.06 g/cm3(Predicted) |
| storage temp. | Store at 0°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| pka | 7.52±0.20(Predicted) |
| form | Solid |
| color | White to Orange to Green |
| InChI | InChI=1S/C13H8O3/c14-8-5-6-10-12(7-8)16-11-4-2-1-3-9(11)13(10)15/h1-7,14H |
| InChIKey | XCJHDJAODLKGLG-UHFFFAOYSA-N |
| SMILES | C1(=O)C2=C(C=CC=C2)OC2=C1C=CC(O)=C2 |
| CAS DataBase Reference | 3722-51-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| HS Code | 29329900 | |||||||||
| NFPA 704 |
|
Sieber Linker price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | H1269 | 3-Hydroxyxanthen-9-one | 3722-51-8 | 1G | ₹3800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | H1269 | 3-Hydroxyxanthen-9-one | 3722-51-8 | 5G | ₹6900 | 2022-05-26 | Buy |
| ALFA India | ALF-H63495-06 | 3-Hydroxyxanthone, 98% | 3722-51-8 | 5g | ₹13461 | 2022-05-26 | Buy |
| ALFA India | ALF-H63495-03 | 3-Hydroxyxanthone, 98% | 3722-51-8 | 1g | ₹2695 | 2022-05-26 | Buy |
| SRL | 18472 | Sieber Linker (3-Hydroxyxanthone) extrapure, 99% | 3722-51-8 | 100mg | ₹2620 | 2022-05-26 | Buy |
Sieber Linker Chemical Properties,Uses,Production
Chemical Properties
White to off-white or grey powder
Uses
Sieber linker (3-Hydroxyxanthen-9-one) is a natural product of the trifluoroacetic acid group found in Hypericum sampsonii and Rhachidosorus mesosorus. It has antiplatelet and anti-inflammatory properties. It also inhibits the expression of tumour necrosis factor-α (TNF-α) in mice. The synthesis of TNF-α is inhibited by Sieber linker, which may be due to its ability to inhibit the enzyme phosphodiesterase 4 (PDE4). Sieber linker also inhibits the binding of PDL1 to dinucleotide phosphate (DNP) and has an inhibitory effect on cancer cells. This molecule can be used for the treatment of infectious diseases, such as malaria and tuberculosis, since it inhibits protein synthesis in bacteria.
Synthesis Reference(s)
Tetrahedron, 43, p. 3075, 1987 DOI: 10.1016/S0040-4020(01)86849-6
Purification Methods
Purify the xanthone by chromatography on SiO2 gel with pet ether/*benzene as eluent. Recrystallise it from *benzene or EtOH. The acetate has m 157-158o. [Itoh et al. J Am Chem Soc 107 4819 1985, Davies et al. J Org Chem 23 307 1958]. [Beilstein 18 H 46, 18 I 315, 18 II 29, 21 III/IV 601.]
Sieber Linker Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Bharavi Laboratories (P) Ltd. | 91 80 2666 7742 | New Delhi, India | 359 | 54 | Inquiry |
| Bharavi Laboratories (P) Ltd. | +91 (80) 2666-1974 | New Delhi, India | 122 | 50 | Inquiry |
| Biokemix | +91 (40) 6662-6366 | New Delhi, India | 487 | 50 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Cjex Biochem Private Limited | 08068441065Ext 459 | Mumbai, India | 14 | 58 | Inquiry |
| Bharavi Laboratories (P) Limited | +91 80 2666 7742 | Bangalore, India | 68 | 58 | Inquiry |
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