Glycolonitrile
- CAS No.
- 107-16-4
- Chemical Name:
- Glycolonitrile
- Synonyms
- 2-HYDROXYACETONITRILE;HYDROXYACETONITRILE;Acetonitrile, hydroxy-;FORMALDEHYDE CYANOHYDRIN;Glyconitrile;HOCH2CN;usafa-8565;USAF a-8565;Glykolonitril;cyanomethanol
- CBNumber:
- CB4781244
- Molecular Formula:
- C2H3NO
- Molecular Weight:
- 57.05
- MOL File:
- 107-16-4.mol
- Modify Date:
- 2024/3/14 15:18:26
| Melting point | -72°C |
|---|---|
| Boiling point | 183°C |
| Density | 1.076 g/mL at 20 °C |
| refractive index |
n |
| Flash point | 133 °F |
| pka | 11.31±0.10(Predicted) |
| Water Solubility | >=10 g/100 mL at 20 ºC |
| Dielectric constant | 27.0（20℃） |
| Stability | Stable, but may react violently with alkalies. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 107-16-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetonitrile, hydroxy-(107-16-4) |
| EPA Substance Registry System | Formaldehyde cyanohydrin (107-16-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300+H310+H330 |
| Precautionary statements | P260-P262-P264-P280-P302+P352+P310-P304+P340+P310 |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28 |
| Safety Statements | 36/37/39-45-36/37-28 |
| RIDADR | UN 3276 6.1/PG 1 |
| OEL | Ceiling: 2 ppm (5 mg/m3) [15-minute] |
| WGK Germany | - |
| RTECS | AM0350000 |
| HazardClass | 6.1(a) |
| PackingGroup | I |
| Toxicity | mouse,LCLo,inhalation,27ppm/8H (27ppm),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE,"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 290, 1969. |
Glycolonitrile price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 50640 | Glycolic acid nitrile solution ~70% in H2O | 107-16-4 | 10ML | ₹6300.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 50640 | Glycolic acid nitrile solution ~70% in H2O | 107-16-4 | 50ML | ₹22570.13 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 374768 | Glycolonitrile 55?wt. % in H2O | 107-16-4 | 25G | ₹7783.18 | 2022-06-14 | Buy |
Glycolonitrile Chemical Properties,Uses,Production
Chemical Properties
light yellow liquid (typically available as a concentrated. Glycolonitrile [107-16-4], hydroxyacetonitrile, formaldehyde cyanohydrin, HOCH2CN, Mr 57.05, bp 183℃ (slight decomp.), d154 1.104, n20D1.4117. Anhydrous glycolonitrile is a colorless liquid which is miscible with water, ethanol and diethyl ether.
Uses
Solvent and organic intermediate.
Production Methods
Glycolonitrile is the result of reaction between formaldehyde and aqueous sodium cyanide in the presence of mineral acid.
General Description
Odorless colorless oil with a sweetish taste. Used in the manufacture of intermediates in pharmaceutical production, as a component of synthetic resins, as a chemical intermediate for organic compounds, and as a solvent.
Air & Water Reactions
Water soluble.
Reactivity Profile
Glycolonitrile may undergo spontaneous and violent decomposition. Traces of alkali (base) promote violent polymerization [Lewis].
Hazard
Toxic by ingestion, inhalation, and skin absorption.
Health Hazard
Extremely toxic, exposure by any route should be avoided; may have fatal consequences; death from asphyxiation may occur similar to that resulting from hydrogen cyanide.
Fire Hazard
Moderate explosion hazard when exposed to heat or by spontaneous chemical reaction in the presence of alkalies if uninhibited. When heated to decomposition, Glycolonitrile emits highly toxic fumes of cyanide and nitrogen oxides. Unstable, may explode on standing. Hazardous polymerization may occur. avoid the presence of alkalis, and exposure to heat.
Potential Exposure
Formaldehyde cyanohydrin is used in the manufacture of intermediates in pharmaceutical produc tion and as a component of synthetic resins as a chemical intermediate for organic compounds, and as a solvent.
Shipping
UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5). UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Incompatibilities
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, and exposure to heat. Unless stabilized with a weak acid solution, traces of alka lis may cause violent polymerization.
Glycolonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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