Amygdalin
- CAS No.
- 29883-15-6
- Chemical Name:
- Amygdalin
- Synonyms
- D-AMYGDALIN;vitamin b17;Bitter AlMond extract;D(-)-AMYGDALIN;LAETRILE;D,L-AMYGDALIN;D-AMYGDALIN HYDRATE;(r)-alpha-((6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)benzeneaceto;(r)-alpha-((6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)benzeneacetonit;rile
- CBNumber:
- CB8363552
- Molecular Formula:
- C20H27NO11
- Molecular Weight:
- 457.43
- MOL File:
- 29883-15-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/5/11 20:10:50
| Melting point | 223-226 °C |
|---|---|
| Boiling point | 563.27°C (rough estimate) |
| alpha | -38.5 º (c=4, H2O) |
| Density | 1.4474 (rough estimate) |
| refractive index | -40 ° (C=2, H2O) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | H2O: 0.1 g/mL hot, clear to very faintly turbid, colorless |
| pka | 12.69±0.70(Predicted) |
| form | Powder |
| color | White to Off-white |
| optical activity | [α]20/D 39±2°, c = 2% in H2O |
| Water Solubility | 83 g/L (25 ºC) |
| Merck | 14,597 |
| BRN | 66856 |
| Stability | Hygroscopic |
| InChIKey | XUCIJNAGGSZNQT-SWRVSKMJSA-N |
| LogP | -2.237 (est) |
| CAS DataBase Reference | 29883-15-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 26-36/37/39-45-24/25 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | OO8450000 | |||||||||
| F | 10-21 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29389090 | |||||||||
| Toxicity | LD50 orl-rat: 522 mg/kg WJMDA2 134,97,81 | |||||||||
| NFPA 704 |
|
Amygdalin price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A6005 | Amygdalin from apricot kernels, ≥99% | 29883-15-6 | 1G | ₹14678.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A6005 | Amygdalin from apricot kernels, ≥99% | 29883-15-6 | 5G | ₹32951.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A6005 | Amygdalin from apricot kernels, ≥99% | 29883-15-6 | 25G | ₹128016.45 | 2022-06-14 | Buy |
| Sigma-Aldrich | 10050 | Amygdalin BioXtra, ≥97.0% (HPLC) | 29883-15-6 | 5G | ₹7101.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 10050 | Amygdalin BioXtra, ≥97.0% (HPLC) | 29883-15-6 | 5G | ₹7101.2 | 2022-06-14 | Buy |
Amygdalin Chemical Properties,Uses,Production
Description
Amygdalin is a cyanogenic glycoside that has been found in seeds from plants of the Rosaceae family and has diverse biological activities. It induces cell cycle arrest at the G0/G1 phase, decreases cyclin A and Cdk2 levels, and inhibits cell growth in UMUC-3, RT112, and TCCSUP bladder cancer cells when used at concentrations ranging from 1.25 to 10 mg/ml. Amygdalin (3 mg/kg) reduces the number of primary microtubules and microvessels in aortic rings isolated from rats with diabetes induced by streptozotocin . In vivo, amygdalin reduces triglyceride, total cholesterol, and LDL levels and aortic sinus plaque area in an LDLR-/- mouse model of atherosclerosis. It also reduces production of TNF-α, IL-1β, and IL-6, as well as neutrophil and macrophage infiltration, in bronchoalveolar lavage fluid (BALF) in a mouse model of LPS-induced acute lung injury.
Chemical Properties
WHITE FINE CRYSTALLINE POWDER
Uses
Amygdalin, a cyanide containing glycoside, may be used as a substrate to identify, differentiate and characterize enzymes such as maltase(s), emulsin(s) and β-glucosidase(s).
Definition
ChEBI: An amygdalin in which the stereocentre on the cyanohydrin function has R-configuration.
World Health Organization (WHO)
Laetrile, which consists mainly of amydgalin, a glycoside extracted from the kernels of apricots, peaches and other fruits, has been available for over 30 years in preparations purporting to be beneficial in the treatment of cancer. Although there is no evidence that these are efficacious, preparations continued to be widely used and, until the late 1970s, they were considered to be harmless. However, oral dosage forms, which may be broken down in the gut to hydrogen cyanide, have subsequently been shown to be potentially lethal. This has resulted in restrictive regulatory measures in several countries.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Safety Profile
Human poison by ingestion(infant data). Poison experimentally by ingestion. Anexperimental teratogen. Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.
Purification Methods
D-Amygdalin recrystallises from water as the trihydrate, or from EtOH. It is present in bitter almonds. [Smith Chem Ber 64 1115 1931, Beilstein 17/8 V 188.]
Amygdalin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4317 | 58 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2337 | 58 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1843 | 58 | Inquiry |
| Brisben Chemicals | 08048963750 | Mumbai, India | 509 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Triveni chemicals | 58 |
| Central Drug House(P) Ltd. | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
| Anand Agencies | 58 |
| HiMedia Laboratories | 58 |
| Brisben Chemicals | 58 |
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