Erythorbic Acid
- CAS No.
- 89-65-6
- Chemical Name:
- Erythorbic Acid
- Synonyms
- D-ISOASCORBIC ACID;(5R)-5-[(1R)-1,2-Dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one;ISOASCORBIC ACID;ERYTHORBATE;araboascorbicacid;D-ARABOASCORBIC ACID;d-arabino-ascorbicacid;Ascorbic Acid EP Impurity F;2,3-didehydro-d-erythro-hexono-1,4-lactone;mercate5
- CBNumber:
- CB3777943
- Molecular Formula:
- C6H8O6
- Molecular Weight:
- 176.12
- MOL File:
- 89-65-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/3 13:03:20
| Melting point | 169-172 °C (dec.) (lit.) |
|---|---|
| Boiling point | 227.71°C (rough estimate) |
| alpha | -17.25 º (c=10, H2O 25 ºC) |
| Density | 1.3744 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | -17.5 ° (C=10, H2O) |
| FEMA | 2410 | ERYTHROBIC ACID |
| storage temp. | 2-8°C |
| solubility | H2O: 0.1 g/mL, clear, colorless to very faintly yellow |
| pka | 4.09±0.10(Predicted) |
| form | Crystals or Crystalline Powder |
| color | White to slightly yellow |
| Odor | odorless |
| optical activity | [α]25/D 16.8°, c = 2 in H2O |
| Water Solubility | 1g/10mL |
| Merck | 14,5126 |
| BRN | 84271 |
| Stability | Stable. Combustible. Incompatible with chemically active metals, aluminium, zinc, copper, magnesium, strong bases, strong oxidizing agents. |
| InChIKey | CIWBSHSKHKDKBQ-JLAZNSOCSA-N |
| LogP | -1.69 at 25℃ |
| CAS DataBase Reference | 89-65-6(CAS DataBase Reference) |
| EPA Substance Registry System | Isoascorbic acid (89-65-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | KF3015000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29329990 | |||||||||
| NFPA 704 |
|
Erythorbic Acid price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W241008 | D-Isoascorbic acid FG | 89-65-6 | 1SAMPLE-K | ₹5141.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W241008 | D-Isoascorbic acid FG | 89-65-6 | 1KG | ₹6971.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W241008 | D-Isoascorbic acid FG | 89-65-6 | 5KG | ₹22288.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2418 | Ascorbic Acid Impurity F Pharmaceutical Secondary Standard; Certified Reference Material | 89-65-6 | 100MG | ₹34066.28 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 856061 | D-(−)-Isoascorbic acid 98% | 89-65-6 | 100G | ₹2262.43 | 2022-06-14 | Buy |
Erythorbic Acid Chemical Properties,Uses,Production
Chemical Properties
Erythorbic acid occurs as a white or slightly yellow-colored crystals or powder. It gradually darkens in color upon exposure to light.
Uses
Erythorbic Acid is a food preservative that is a strong reducing agent (oxygen accepting) which functions similarly to antioxidants. In the dry crystalline state it is nonreactive, but in water solutions it reacts readily with atmospheric oxygen and other oxidizing agents, making it valuable as an antioxidant. During preparation, dissolving and mixing should incorporate a minimum amount of air, and storage should be at cool temperatures. It has a solubility of 43 g/100 ml of water at 25°c. One part is equivalent to one part ascorbic acid and equivalent to one part sodium erythorbate. It is used to control oxidative color and flavor deterioration in fruits at 150–200 ppm. It is used in meat curing to speed and control the nitrite curing reaction and prolong the color of cured meat at levels of 0.05%.
Production Methods
Erythorbic acid is synthesized by the reaction between methyl 2- keto-D-gluconate and sodium methoxide. It can also be synthesized from sucrose, and produced from Penicillium spp.
Pharmaceutical Applications
Erythorbic acid is a stereoisomer of L-ascorbic acid, and is used as an antioxidant in foods and oral pharmaceutical formulations. It has approximately 5% of the vitamin C activity of L-ascorbic acid.
Safety
Erythorbic acid is widely used in food applications as an
antioxidant. It is also used in oral pharmaceutical applications as
an antioxidant. Erythorbic acid is generally regarded as nontoxic
and nonirritant when used as an excipient. Erythorbic acid is readily
metabolized and does not affect the urinary excretion of ascorbic
acid.
The WHO has set an acceptable daily intake of erythorbic acid
and its sodium salt in foods at up to 5 mg/kg body-weight.
Solubility in organics
40% soluble in water. Soluble in alcohol, slightly soluble in Glycerin and Propylene glycol.
storage
Erythorbic acid should be stored in an airtight container, protected from light, in a cool, dry place.
Purification Methods
Crystallise D(-)-isoascorbic acid from H2O, EtOH or dioxane. is at 245nm with 7,500 (EtOH). [Reichstein et al. Helv max Chim Acta 17 510, 516 1934, Heslop et al. J Chem Soc 225 1944, Beilstein 18 III/IV 3037, 18/5 V 26.]
Incompatibilities
Erythorbic acid is incompatible with chemically active metals such as aluminum, copper, magnesium, and zinc. It is also incompatible with strong bases and strong oxidizing agents.
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral concentrate and tablets).
Erythorbic Acid Preparation Products And Raw materials
Raw materials
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| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| BTC pharm India | +918790379245 | AndhraPradesh, India | 1269 | 58 | Inquiry |
| Anant Pharmaceuticals Pvt Ltd | +91-8550986868 +91-9485998001 | Haryana, India | 461 | 58 | Inquiry |
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Uni-Chemie International | 91-22-28881114 | Maharashtra, India | 62 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| BTC pharm India | 58 |
| Anant Pharmaceuticals Pvt Ltd | 58 |
| HRV Global Life Sciences | 58 |
| Uni-Chemie International | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| Alfa Aesar | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| SynZeal Research Pvt Ltd | 58 |
| Reax Chemicals | 58 |
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