ETHYL ISOCYANIDE
- CAS No.
- 624-79-3
- Chemical Name:
- ETHYL ISOCYANIDE
- Synonyms
- lsocyanoethane;isocyanoethane;HANSA ISN-0734;ETHYL ISOCYANIDE;ethyl isonitrile;ethyl carbylamine;ethyl isocyanide DISCONTINUED
- CBNumber:
- CB4131836
- Molecular Formula:
- C3H5N
- Molecular Weight:
- 55.08
- MOL File:
- 624-79-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/4 15:12:25
| Boiling point | 96.85°C (estimate) |
|---|---|
| Density | 0.7378 |
| refractive index | 1.3607 |
| Water Solubility | 999mg/L(temperature not stated) |
| EPA Substance Registry System | Ethane, isocyano- (624-79-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS02 |
|---|---|
| Signal word | Danger |
| Hazard statements | H225-H302-H332-H312 |
| Precautionary statements | P261-P271-P304+P340-P312-P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501 |
ETHYL ISOCYANIDE Chemical Properties,Uses,Production
Uses
Principal use in toxicology was in the characterization of cytochrome P450 isozymes. Ethyl isocyanide and the reduced cytochrome form a characteristic optical difference spectrum with two peaks in the Soret Region (type III). The pH equilibrium point (the pH at which the two peaks are of equal height) varies between different isozymes.
Preparation
CAUTION: The reaction and distillation should be conducted behind a safety shield. Precautions for handling toxic cyanides should be observed.
To a three-necked flask equipped with a condenser and ground glass stirrer (or Hershberg stirrer) is added 116 gm (0.75 mole) of ethyl iodide and 100 gm (0.75 mole) of silver cyanide. The mixture is refluxed for 2 hr, the stirrer blade raised, the mixture cooled, filtered (see Note a), the solid washed with ether, dried, and 260 gm of a 50% solution of potassium cyanide (2.0 moles) added. The reaction mixture is distilled to afford a mixture of isonitrile and water (see Note b). The crude isonitrile 49.5- 52.3 gm (90-95%) is separated after being salted out of the water. The isonitrile is washed twice with 24-ml portions of ice-cold saturated sodium chloride solution, dried over magnesium sulfate, and fractionally distilled, to afford 25.9-30.3 gm (47-55%), b.p. 77-79°C (760 mm Hg).
ETHYL ISOCYANIDE Preparation Products And Raw materials
Raw materials
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ETHYL ISOCYANIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Honest Joy Holdings Limited | 755-36694831 +8613798234863 | China | 999 | 58 | Inquiry |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 021-51613915-820 13611835272 | China | 9747 | 57 | Inquiry |
| Beta Pharma, Inc. | 203 786 5436 | United States | 6238 | 60 | Inquiry |
| Hansa Fine Chemicals GmbH | +49 42121 89200 | Germany | 3132 | 38 | Inquiry |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 15229059051 | China | 9967 | 58 | Inquiry |
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