geninthiocin
- CAS No.
- 158792-27-9
- Chemical Name:
- geninthiocin
- Synonyms
- geninthiocin;Geninthiocin A;PubChem ID: 16129809;14-DeMethylberinaMycin;Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro-, (7→1)-...
- CBNumber:
- CB41333237
- Molecular Formula:
- C50H49N15O15S
- Molecular Weight:
- 1132.08
- MOL File:
- 158792-27-9.mol
- Modify Date:
- 2023/5/21 10:59:17
geninthiocin Chemical Properties,Uses,Production
Description
Geninthiocin A is a cyclic thiopeptide bacterial metabolite originally isolated from Streptomyces sp. DD84. It is active against a variety of Gram-positive bacteria (MICs = 0.2-4 μg/ml), the Gram-negative bacterium C. violaceum (MIC = 19 μg/ml), and the fungus M. hiemalis (MIC = 38 μg/ml). Geninthiocin A also induces tipA promoter transcription with a minimum induction concentration of 1.2 ng/ml.
Uses
Geninthiocin, a thiopeptide antibiotic isolated from a Streptomyces sp., is a potent activator of the tipA gene, a bacterial transcription regulator involved in multidrug resistance. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines, whereas the related dedialanyl geninthiocin shows the reverse selectivity. Geninthiocin is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.
geninthiocin Preparation Products And Raw materials
Raw materials
Preparation Products
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BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | China | 9806 | 58 | Inquiry |
TargetMol Chemicals Inc. | 4008200310 | China | 24647 | 58 | Inquiry |
cfm Oskar Tropitzsch | +49 9231961928 | Germany | 1136 | 62 | Inquiry |
Tebu-bio | France | 251 | 75 | Inquiry | |
Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | China | 56354 | 58 | Inquiry |
Shanghai Bosheng Biotechnology Co., Ltd. | 021-54253791 13701878781 | CHINA | 790 | 58 | Inquiry |
Beijing Taize Jiaye Technology Development Co., Ltd. | 400-800-8151 | CHINA | 6050 | 58 | Inquiry |
Xiamen Huijia Biological Technology Co., Ltd. | 0592-6020891 | CHINA | 6979 | 58 | Inquiry |