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4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime

4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Structure
CAS No.
55224-94-7
Chemical Name:
4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
Synonyms
AP-18;4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime;4-(4-Chlorophenyl)-3-methyl-3-buten-2-oneoxime;4-(4-Chlorophenyl)-3-methylbut-3-en-2-one oxime;3-Buten-2-one, 4-(4-chlorophenyl)-3-methyl-, oxime;ganglia,TRP Channel,nerves,pain,AP18,Transient receptor potential channels,AP-18,AP 18,inhibit,nociceptive,root,hyperalgesia,Inhibitor,transduction,dorsal
CBNumber:
CB42096355
Molecular Formula:
C11H12ClNO
Molecular Weight:
209.67
MOL File:
55224-94-7.mol
MSDS File:
SDS
Modify Date:
2023/9/4 15:51:00
Request For Quotation

4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Properties

storage temp. 2-8°C
solubility DMSO: >10mg/mL
form solid
color white to off-white
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
NFPA 704
1
2 0

4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) A7232 AP-18 ≥98% (HPLC), solid 55224-94-7 5MG ₹10930 2022-06-14 Buy
Sigma-Aldrich(India) A7232 AP-18 ≥98% (HPLC), solid 55224-94-7 25MG ₹45140 2022-06-14 Buy
Product number Packaging Price Buy
A7232 5MG ₹10930 Buy
A7232 25MG ₹45140 Buy

4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Chemical Properties,Uses,Production

Description

AP-18 is a channel blocker which reversibly inhibits TRPA1 (IC50s = 3.1 and 4.5 μM, human and mouse, respectively). It has minimal effect on TRPV1-4 or TRPM8. AP-18 has been used to study TRPA1 signaling in mice and rats as well as in vitro.

Uses

AP-18 is a channel blocker that inhibits TRPA1.

Biological Activity

Reversible TRPA1 channel blocker (IC 50 values are 3.1 and 4.5 μ M at human and mouse TRPA1 respectively). Blocks cinnameldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo . Also blocks TRPA1 pore dilation (IC 50 = 10.3 μM for the inhibition of Yo-Pro uptake).

4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Preparation Products And Raw materials

Raw materials

Preparation Products

4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Suppliers

Global( 57)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 China 9707 58 Inquiry
BOC Sciences USA 0 65 Inquiry
RD International Technology Co., Limited 18024082417 China 9274 58 Inquiry
SIGMA-RBI 800 736 3690 (Orders) Switzerland 6913 91 Inquiry
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 China 15848 69 Inquiry
Toronto Research Chemicals +1 (416) 665-9696 Canada 6088 71 Inquiry
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 China 96815 76 Inquiry
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 China 56070 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Cayman Chemical Company 81
Shanghai EFE Biological Technology Co., Ltd. 58
BOC Sciences 65
RD International Technology Co., Limited 58
SIGMA-RBI 91
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Toronto Research Chemicals 71
J & K SCIENTIFIC LTD. 76
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58

4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Spectrum

4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime(55224-94-7)1HNMR

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AP-18 4-(4-Chlorophenyl)-3-methyl-3-buten-2-oneoxime 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime 3-Buten-2-one, 4-(4-chlorophenyl)-3-methyl-, oxime 4-(4-Chlorophenyl)-3-methylbut-3-en-2-one oxime ganglia,TRP Channel,nerves,pain,AP18,Transient receptor potential channels,AP-18,AP 18,inhibit,nociceptive,root,hyperalgesia,Inhibitor,transduction,dorsal 55224-94-7 C11H12CINO Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals