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ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID

CAS No.: 31842-01-0

Chemical Name:: ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID

Synonyms: k4277;flosin;Praxis;flosint;Bor-ind;Reumofe;isindone;Reumofene;INDOPROFEN;Aids025462

CBNumber:: CB4297426

Molecular Formula:: C17H15NO3

Molecular Weight:: 281.31

MOL File:: 31842-01-0.mol

MSDS File:: SDS

Modify Date:: 2024/11/19 20:33:22

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ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID Properties

Melting point	213-214°
Boiling point	423.97°C (rough estimate)
Density	1.1302 (rough estimate)
refractive index	1.4500 (estimate)
storage temp.	2-8°C
solubility	Methanol (Slightly, Sonicated)
form	Solid
pka	pKa 5.8 (Uncertain)
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06,GHS08
Signal word	Danger
Hazard statements	H301-H351
Precautionary statements	P201-P301+P310+P330
Hazard Codes	T
Risk Statements	25-40
Safety Statements	22-36/37/39-45
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3
RTECS	MU6645000
Toxicity	LD50 in rats (mg/kg): 58.66 i.v.; 60.83 orally (Buttinoni)

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	I3132	Indoprofen analytical standard	31842-01-0	1G	₹5477.45	2022-06-14	Buy

Product number	Packaging	Price	Buy
I3132	1G	₹5477.45	Buy

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID Chemical Properties,Uses,Production

Chemical Properties

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID is Off-White Solid

Uses

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID is a non-steroidal anti-inflammatory agent used for treatment of pain and inflammation

Definition

ChEBI: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causi g severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.

World Health Organization (WHO)

Indoprofen, a nonsteroidal anti-inflammatory agent, was introduced in 1976 for the treatment of rheumatic disorders. By 1983 its use had been associated with serious adverse effects, some of which were fatal. This led to its withdrawal in the United Kingdom and Cyprus. In 1984 reports of intestinal tumours in rats led to the drug's temporary withdrawal in Germany and Italy. This was followed immediately by the suspension of marketing worldwide by the major manufacturer.

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID Preparation Products And Raw materials

Raw materials

Ethyl 2-chloromethylbenzoate Potassium hydroxide Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-methyl-, ethyl ester Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-methyl-, methyl ester Benzeneacetic acid, 4-(1,3-dihydro-2H-isoindol-2-yl)-α-methyl-, ethyl ester

1H-Isoindol-1-one, 2-(4-chlorophenyl)-2,3-dihydro- 4-aminohydratropic acid ethyl 2-(4-aminophenyl)propionate 2-(4-NITROPHENYL)PROPIONIC ACID ethyl 2-(4-nitrophenyl)propionate

ZINC carbon monoxide Carbon dioxide 2-Carboxybenzaldehyde

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Preparation Products

ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID Suppliers

Global( 81)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	China	29793	60	Inquiry
Hangzhou FandaChem Co.,Ltd.	+8615858145714	China	8778	55	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49374	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29810	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32161	58	Inquiry
TargetMol Chemicals Inc.		United States	38631	58	Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	China	33338	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57505	58	Inquiry
TargetMol Chemicals Inc.	+8613564774135	United States	19884	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Capot Chemical Co.,Ltd.	60
Hangzhou FandaChem Co.,Ltd.	55
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
TargetMol Chemicals Inc.	58

31842-01-0(ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID)Related Search:

Indoramin D5 Indacaterol Maleate Veratraldehyde Benyl propionic methyl ester Indole-3-carboxaldehyde

DL-INDOLE-3-LACTIC ACID INDOMETHACIN ACYL-B-D-GLUCURONIDE 3-INDOXYL SULFATE POTASSIUM SALT Indole Ibuprofen

4-(DIMETHYLAMINO)PHENYLACETIC ACID 4-(DIMETHYLAMINO)PHENETHYL ALCOHOL ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID dexindoprofen Actarit

Indobufen 4-ISOPROPYLACETANILIDE 4-Aminophenylacetic acid

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ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID 1-oxo-2-(p-((alpha-methyl)carboxymethyl)phenyl)isoindoline 2-(4-(1-carboxyethyl)phenyl)-1-isoindolinone 2-(p-(1-oxo-2-isoindolinyl)phenyl)-propionicaci 4-(1,3-dihydro-1-oxo-2h-isoindol-2-yl)-alpha-methyl-benzeneaceticaci 4-(1,3-dihydro-1-oxo-2h-isoindol-2-yl)-alpha-methylbenzeneaceticacid alpha-(4-(1-oxo-2-isoindolinyl)phenyl)-propionicaci alpha-(4-(1-oxo-2-iso-indolinyl)-phenyl)-propionicacid flosin INDOPROFEN flosint isindone k4277 p-(1-oxo-2-isoindolinyl)-hydratropicaci p-(1-oxo-2-isoindolinyl)-hydratropicacid α-methyl-p-(1-oxo-2-isoindolinyl)benzeneacetic acid 1-Oxo-2-[p-[(a-methyl)carboxymethyl]phenyl]isoindoline 2-[4-(1-Oxo-2-isoindolinyl)phenyl]propanoic Acid 4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-a-methylbenzeneacetic Acid Bor-ind Praxis Reumofe Indoprofen Solution, 100ppm 2-[p-(1-Oxo-2-isoindolinyl)phenyl]propionic acid 4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-α-methylbenzeneacetic acid Aids025462 Aids-025462 Reumofene Indoprofen,α-Methyl-p-(1-oxo-2-isoindolinyl)benzeneacetic acid 2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic acid (+/-) Indoprof 1-Oxo-2-[p-[(α-Methyl)carboxyMethyl]phenyl]isoindoline Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-methyl- (±)-Indoprofe inhibit,Indoprofen,Inhibitor Indoprofen Indoprofen 31842-01-0 Analytical Chromatography Product Catalog Alphabetic Analytical Standards Pharmaceuticals Aromatics Heterocycles Intermediates & Fine Chemicals