Methyl 3-amino-4-methylbenzoate
- CAS No.
- 18595-18-1
- Chemical Name:
- Methyl 3-amino-4-methylbenzoate
- Synonyms
- AKOS BB-3092;3-Amino-p-toluic;Compound Fr13901;Methyl 3-amino-4-met;Nilotinib Impurity 25;LABOTEST-BB LT00848257;Nilotinib EP Impurity B;3-Amino-4-Methylbenzoate;METHYL 3-AMINO-P-TOLUATE;3-amino-2,4-dimethylbenzoate
- CBNumber:
- CB4316035
- Molecular Formula:
- C9H11NO2
- Molecular Weight:
- 165.19
- MOL File:
- 18595-18-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/28 13:36:31
| Melting point | 113-117 °C(lit.) |
|---|---|
| Boiling point | 296.3±20.0 °C(Predicted) |
| Density | 1.132±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 3.31±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to cream |
| BRN | 2088611 |
| InChIKey | YEPWCJHMSVABPQ-UHFFFAOYSA-N |
| LogP | 1.7 at 22℃ and pH7 |
| CAS DataBase Reference | 18595-18-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P280-P302+P352-P304+P340+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29224999 | |||||||||
| NFPA 704 |
|
Methyl 3-amino-4-methylbenzoate price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ALFA India | ALF-A15348-22 | Methyl 3-amino-4-methylbenzoate, 97% | 18595-18-1 | 100g | ₹32982 | 2022-05-26 | Buy |
| ALFA India | ALF-A15348-14 | Methyl 3-amino-4-methylbenzoate, 97% | 18595-18-1 | 25g | ₹3388 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A1432 | Methyl 3-Amino-4-methylbenzoate min. 98.0 % | 18595-18-1 | 25G | ₹4700 | 2022-05-26 | Buy |
| ALFA India | ALF-A15348-06 | Methyl 3-amino-4-methylbenzoate, 97% | 18595-18-1 | 5g | ₹1230 | 2022-05-26 | Buy |
Methyl 3-amino-4-methylbenzoate Chemical Properties,Uses,Production
Description
Methyl 3-amino-4-methylbenzoate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Chemical Properties
Beige powder
Uses
Methyl 3-Amino-4-methylbenzoate is used as a reagent in the synthesis of perfluoroalkylated indoles which are very useful in drug development. It was also used in the preparation of 4-(pyrimidin-2-ylamino) benzamide derivatives which are designed as inhibitors of hedgehog signalling pathway (target of cancer treatment).
Application
Methyl 3-amino-4-methylbenzoate can be used for:
To prepare the methyl 4-methyl-3-((4-(proparg-1-yloxy)benzyl)amino)benzoate, 4-proparg-1-yloxybenzaldehyde (16) and methyl 3-amino-4-methylbenzoate were reacted according to the method IA.
Synthesis of Methyl 4-methyl-3-((4-(2-methylthiazol-4-yl)benzoyl)amino)benzoate
Synthesis of 4-Methyl-3-((4-(2-methylthiazol-4-yl)benzoyl)amino)benzamide
Synthesis of methyl 3-(4-hydroxy-6-methyl-2-oxopyridin-1 (2H)-yl)-4-methylbenzoate
Synthesis of (5-Carbomethoxy-2-methylphenyl)(4-hydroxypheny)diazene: To a solution of 6N HC1 (6 mL) was added methyl 3-amino-4-methylbenzoate (1.62 g, 10.0 mmol). The solution was cooled in an ice-bath, and was diazotized by adding sodium nitrite (0.9 g, 12.0 mmol). To a cold solution of phenol in 21% aqueous NaOH solution (6 mL) was added diazotized solution slowly. After 20 min, the solution was acidfied by adding 4 N aqueous HC1 and was poured into the cold water, filtered, and washed with water. Recrystallization from ethanol gave the product (2.0 g, 74%) as red crystals, mp 181.3-182.2 °C.
Preparation
Synthesis of Methyl 3-amino-4-methylbenzoate: Nitro ester Methyl 4-methyl-3-nitrobenzoate (80 g, 0.410 mol) was subjected to hydrogenation in a Parr shaker in MeOH using Raney Ni as the catalyst (5 g, 20 mol %) at 50 psi for 8 hours. The catalyst was filtered off, washed thoroughly with MeOH and the combined filtrates concentrated under reduced pressure to furnish a yellow solid (65.0 g). Yield : 96% Mp : 114-5°C (lit.14 Mp 116°C)
Methyl 3-amino-4-methylbenzoate Preparation Products And Raw materials
Raw materials
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