MILBEMECTIN A3

MILBEMECTIN A3 Structure
CAS No.
51596-10-2
Chemical Name:
MILBEMECTIN A3
Synonyms
milbemycin;Milbemycin α1;milbemycin A3;milbemycinb-2;Milbemycin α1;MILBEMECTIN A3;milbemectine a3;Antibiotic B-41A3;Milbemycin oxime A3;Milbemycin EP Imp B
CBNumber:
CB4359654
Molecular Formula:
C31H44O7
Molecular Weight:
528.69
MOL File:
51596-10-2.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:31:18

MILBEMECTIN A3 Properties

Melting point 212-215°; mp 192-194°
alpha D20 +106° (c = 0.25 in acetone) (Aoki); D20 +106° (acetone) (Hirama)
Boiling point 725.5±60.0 °C(Predicted)
Density 1.21±0.1 g/cm3(Predicted)
storage temp. 0-6°C
solubility DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
form A solid
pka 12.46±0.70(Predicted)
EPA Substance Registry System Milbemycin A3 (51596-10-2)

SAFETY

Risk and Safety Statements

RIDADR  2588
HazardClass  6.1(b)
PackingGroup  III

MILBEMECTIN A3 Chemical Properties,Uses,Production

Description

Milbemycin A3 is a member of a complex family of macrocyclic lactones that contain a characteristic spiroketal group produced from the fermentation of soil bacterium S. hygroscopicus subsp. aureolacrimosus. As a compound that potentiates glutamate and GABA-gated chloride-channel opening, milbemycin A3 is used as a nematocide and insecticide. The acaricidal and nematocidal activity of a mixture of milbemycin A3 and milbemycin A4 against adult spider mites, spider mite eggs, and C. elegans are reported at IC50 values of 5.3, 41.1, and 9.5 μg/ml.

Uses

Milbemycins are a complex family of macrocyclic lactones containing a highly characteristic spiroketal group, produced by Streptomyces hydroscopicus subsp. aureolarcrimosus. Milbemycin A3 is a major member of a group of analogues containing a 25-methyl substituent. Milbemycin A3 is a highly selective and potent nematocide and insecticide. Like the closely related avermectins, milbemycins are thought to act on chloride-gated ion channels.

MILBEMECTIN A3 Preparation Products And Raw materials

Raw materials

Preparation Products

MILBEMECTIN A3 Suppliers

Global( 63)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Shanghai Longyu Biotechnology Co., Ltd. +8613917842738 China 2534 58 Inquiry
BOC Sciences 16314854226; +16314854226 United States 19743 58 Inquiry
Alfa Chemistry United States 24072 58 Inquiry
China National Standard Pharmaceutical Corporation Limited +8615391658522 China 11927 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Nantong Hanfang Biotechnology Co. , Ltd. 18616537568 China 30968 58 Inquiry
Cato Research Chemicals Inc. 020-81960175-877 18933936954 China 7738 58 Inquiry
milbemectine a3 MILBEMECTIN A3 milbemycinb-2 milbemycin A3 (25R)-25-Methyl-5β-hydroxy-5-demethoxy-28-O,6β-cyclomilbemycin B (6R,25R)-5-O-Demethyl-28-deoxy-6,28-epoxy-25-methylmilbemycin B Antibiotic B-41A3 Milbemycin α1 B 41A3, MilbeMycin alpha1, MilbeMectin Milbemycin oxime A3 (+)-Chloropseudoephedrine (hydrochloride) Milbemycin EP Impurity B Milbemycin Impurity 2(Milbemycin EP Impurity B) Milbemycin EP Imp B Milbemycin B, 5-O-demethyl-28-deoxy-6,28-epoxy-25-methyl-, (6R,25R)- Milbemite Impurity 1 Milbemycin Oxime EP Impurity B Milbemycin α1 milbemycin 51596-10-2 51596-20-2 C31H44O7