DL-Threonine
- CAS No.
- 80-68-2
- Chemical Name:
- DL-Threonine
- Synonyms
- THREONINE;H-DL-THR-OH;DL-Thr;DT 5621;DL-Thr-OH;DL-Threonin;Radish Seed;DL-Threoine;Bucladesina;DL-Theronine
- CBNumber:
- CB4475055
- Molecular Formula:
- C4H9NO3
- Molecular Weight:
- 119.12
- MOL File:
- 80-68-2.mol
- Modify Date:
- 2024/7/1 9:08:13
| Melting point | 244 °C (dec.)(lit.) |
|---|---|
| Boiling point | 222.38°C (rough estimate) |
| alpha | [α]D20 0±1.0゜ (c=6, H2O) |
| Density | 1.3126 (rough estimate) |
| refractive index | 1.4183 (estimate) |
| storage temp. | Store at RT. |
| solubility | Soluble in water, Insoluble in absolute alcohol and oils |
| pka | 2.09(at 25℃) |
| form | Powder |
| color | White |
| Water Solubility | 200 g/L (25 ºC) |
| Merck | 14,9380 |
| BRN | 1721647 |
| LogP | -1.136 (est) |
| CAS DataBase Reference | 80-68-2(CAS DataBase Reference) |
| NIST Chemistry Reference | DL-Threonine(80-68-2) |
| EPA Substance Registry System | Threonine (80-68-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29225000 | |||||||||
| NFPA 704 |
|
DL-Threonine price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T8375 | DL-Threonine ≥95% (titration) | 80-68-2 | 100G | ₹12167.3 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T3105 | DL-Threonine (contains DL-Allothreonine) | 80-68-2 | 25G | ₹4000 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T3105 | DL-Threonine (contains DL-Allothreonine) | 80-68-2 | 100G | ₹17000 | 2022-05-26 | Buy |
| ottokemi | T 1696 | DL-Threonine, for biochemistry 99%+ | 80-68-2 | 25gm | ₹2889 | 2022-05-26 | Buy |
| SRL | 75164 | DL-Threonine extrapure CHR, 99% | 80-68-2 | 5Gms | ₹510 | 2022-05-26 | Buy |
DL-Threonine Chemical Properties,Uses,Production
Description
Threonine (abbreviated as Thr or T) is an α-amino acid with the chemical formula HO2CCH(NH2)CH(OH)CH3. Its codons are ACU, ACA, ACC, and ACG. This essential amino acid is classified as polar. Together with serine, threonine is one of two proteinogenic amino acids bearing an alcohol group (tyrosine is not an alcohol but a phenol, since its hydroxyl group is bonded directly to an aromatic ring, giving it different acid/base and oxidative properties). It is also one of two common amino acids that bear a chiral side chain, along with isoleucine.
The threonine residue is susceptible to numerous posttr anslational modifications. The hydroxy side-chain can undergo Olinked glycosylation. In addition, threonine residues undergo phospho rylation through the action of a threonine kinase. In its phosphorylated form, it can be referred to as phospho threonine.
Chemical Properties
White crystalline powder
Occurrence
Foods high in threonine include cottage cheese, poultry, fish, meat, lentils, Black turtle bean and Sesame seeds.
Racemic threonine can be prepared from crotonic acid by alphafunctionalization using mercury (II) acetate.
History
Threonine was discovered as the last of the 20 common proteinogenic amino acids in the 1930s by William Cumming Rose.
Uses
DL-Threonine is used as a polar essential amino acid. It serves as a precursor of glycine as well as used in the biosynthesis of proteins. Further, it is used for biochemical research. In addition to this, it is used as a nutrition enhancer.
Biosynthesis
As an essential amino acid, threonine is not synthesized in humans, hence we must ingest threonine in the form of threoninecontaining proteins. In plants and microorganisms, threonine is synthesized from aspartic acid via α-aspartyl-semialdehyde and homoserine. Homoserine undergoes O-phosphorylation; this phosphate ester undergoes hydrolysis concomitant with relocation of the OH group. Enzymes involved in a typical biosynthesis of threonine include :
aspartokinase
β-aspartate semialdehyde dehydrogenase
homoserine dehydrogenase
homoserine kinase
threonine synthase.
Metabolism
Threonine is metabolized in two ways:
It is converted to pyruvate via threonine dehydrogenase. An intermediate in this pathway can undergo thiolysis with CoA to produce acetyl-CoA and glycine.
In humans, it is converted to α-ketobutyrate in a less common pathway via the enzyme serine dehydratase, and thereby enters the pathway leading to succinyl-CoA.
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DL-Threonine Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SYNOVA CHEMICALS | +91-9920741772 +91-9920741772 | Mumbai, India | 428 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Central Drug House(P) Ltd. | 91-11-49404040 | New Delhi, India | 6160 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| LOBA CHEMIE PVT.LTD. | 91-22-6663 6699 | Mumbai, India | 3077 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | New Delhi, India | 6093 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| SYNOVA CHEMICALS | 58 |
| JSK Chemicals | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Central Drug House(P) Ltd. | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| LOBA CHEMIE PVT.LTD. | 58 |
| Triveni chemicals | 58 |
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