ChemicalBook > Product Catalog >Organic Chemistry >Organic fluorine compound >Fluorotoluene series >4-Nitro-3-trifluoromethyl aniline
4-Nitro-3-trifluoromethyl aniline
- CAS No.
- 393-11-3
- Chemical Name:
- 4-Nitro-3-trifluoromethyl aniline
- Synonyms
- FLU-1;4-Nitro-α,α,α;TIMTEC-BB SBB006652;Flutamide Impurity A;Nilutamide Impurity 3;Nilutamide impurity B CRS;FlutaMide Related CoMpound A;2-Nitro-5-aminobenzotriluoride;5-AMINO-2-NITROBENZOTRIFLUORIDE;3-AMINO-6-NITROBENZOTRIFLUORIDE
- CBNumber:
- CB4483928
- Molecular Formula:
- C7H5F3N2O2
- Molecular Weight:
- 206.12
- MOL File:
- 393-11-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/24 19:19:26
| Melting point | 125-129 °C (lit.) |
|---|---|
| Boiling point | 326.4±42.0 °C(Predicted) |
| Density | 1.4711 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | -0.22±0.10(Predicted) |
| color | Yellow to Orange-Yellow |
| BRN | 2650702 |
| InChIKey | UTKUVRNVYFTEHF-UHFFFAOYSA-N |
| CAS DataBase Reference | 393-11-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 5-Amino-2-nitrobenzotrifluoride(393-11-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36-36/37 | |||||||||
| WGK Germany | 2 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29214200 | |||||||||
| NFPA 704 |
|
4-Nitro-3-trifluoromethyl aniline price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A68807 | 4-Nitro-3-(trifluoromethyl)aniline 98% | 393-11-3 | 5G | ₹4362.48 | 2022-06-14 | Buy |
| TCI Chemicals (India) | A0377 | 5-Amino-2-nitrobenzotrifluoride min. 98.0 % | 393-11-3 | 5G | ₹4800 | 2022-05-26 | Buy |
| ALFA India | ALF-A13798-06 | 4-Nitro-3-(trifluoromethyl)aniline, 98% | 393-11-3 | 5g | ₹6122 | 2022-05-26 | Buy |
| TCI Chemicals (India) | A0377 | 5-Amino-2-nitrobenzotrifluoride min. 98.0 % | 393-11-3 | 25G | ₹7300 | 2022-05-26 | Buy |
| ALFA India | ALF-A13798-03 | 4-Nitro-3-(trifluoromethyl)aniline, 98% | 393-11-3 | 1g | ₹1430 | 2022-05-26 | Buy |
4-Nitro-3-trifluoromethyl aniline Chemical Properties,Uses,Production
Chemical Properties
Orange to Brown to Dark red powder to crystal.
Uses
A metabolite of Flutamide (FLU-1 or M2).
Synthesis
The
thiazolium salt 3 (3.30 mg, 0.0122 mmol) was added to a solution of
1-azido-4-nitrobenzene (0.122 mmol) and t-BuOH (18.0 mg, 0.244 mmol) in
degassed THF (0.50 mL) under argon at r.t. The resulting suspension was
stirred for 5 min, and then NaOt-Bu (23.4 mg, 0.244 mmol) was added in
one portion, and the mixture was stirred (Table 2). Water (2 mL) was
added, and the products were extracted with EtOAc (2 ?á 2 mL), the
combined organic phase was dried over anhyd MgSO4, filtered,
and concentrated in vacuo. Purification was achieved by passing the
resulting residue through a short pad of silica (eluting with 50% light
PE-EtOAc) unless otherwise stated.
4-Nitro-3-trifluoromethyl aniline, Time: 12 h, Pale yellow
solid (21.0 mg, 84%). (70:30 petrol-EtOAc) 0.5; mp 90-93 ??C (lit.,
92-93 ??C); IR (FTIR, CHCl3) |ímax cm-1: 3535 (NH2), 3434 (NH2), 1635, 1592 (NO2), 1520 (NO2), 1119; 1H NMR (400 MHz, DMSO-6) 8.59 (d, = 2.7 Hz, 1H), 8.55 (dd, = 9.3, 2.7 Hz, 1H), 7.55 (br s, 2H), 7.32 (d, = 9.3 Hz, 1H); 13C NMR (100 MHz, DMSO-6) 151.8 (C), 135.0 (C), 128.7 (CH), 123.7 (J = 5.9 Hz, F3N2NaO2 [M+Na]+, 229.0195; found, 229.0195.
Fig. The synthetic of 4-Nitro-3-trifluoromethyl aniline
4-Nitro-3-trifluoromethyl aniline Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 408)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CNS CHEMICALS | +91-9381957258 +91-9381957258 | Telangana, India | 354 | 58 | Inquiry |
| Kekule Pharma Limited | +919849798889 | Hyderabad, India | 59 | 58 | Inquiry |
| Orgamine Chemicals(I) Pvt Ltd | +91-9820080281 +91-9820080281 | Maharashtra, India | 451 | 58 | Inquiry |
| Medilux Laboratories Pvt Ltd | +91-7292409991 +91-9819666688 | Madhya Pradesh, India | 102 | 58 | Inquiry |
| Ebenezer Industries | Gujarat, India | 96 | 58 | Inquiry | |
| Avra Synthesis Pvt Ltd | +914027175796 | New Delhi, India | 1606 | 30 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2337 | 58 | Inquiry |
| Zandu Chemicals Limited | +91 22 2430 7021 | Mumbai, India | 19 | 58 | Inquiry |
| Myosynth Laboratories Private Limited | 91-891-3266227 | Andhra Pradesh, India | 30 | 58 | Inquiry |
| MEDILUX LABORATORIES PRIVATE LIMITED | +91 72924 09991 | New Delhi, India | 66 | 58 | Inquiry |
Related articles
- Synthesis and application of 4-Nitro-3-trifluoromethyl aniline
- 4-Nitro-3-trifluoromethyl aniline can be used to prepare non steroidal antiandrogenic drug flutamide.
- Oct 13，2022
393-11-3(4-Nitro-3-trifluoromethyl aniline)Related Search:
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4-Nitro-α,α,α
4-Nitro-3-(trifluoromethyl)aniline (FLU-1)
5-Amino-2-nitrobenzotrifluoride, 4-Nitro-α,α,α-trifluoro-m-toluidine
4-nitro-3-(trifluoromethyl)benzenamine
FLU-1
4-Nitro-3-(trifluoromethyl)aniline ,98%
FlutaMide Related CoMpound A
The 4- nitro-3- threetrifluoroMethylaniline
4-Nitro-4-(trifluoromethyl)aniline
Flutamide Related Compound A (20 mg) (4-nitro-3-(trifluoromethyl)aniline)
4-Nitro-3-(trifluoromethyl)aniline 98%
2-NITRO-5-AMINO BENZOTRIFLUORIDE
5-AMINO-2-NITROBENZOTRIFLUORIDE
4-NITRO-3-(TRIFLUOROMETHYL)ANILINE
4-NITRO-ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLUIDINE
3-AMINO-6-NITROBENZOTRIFLUORIDE
TIMTEC-BB SBB006652
Benzenamine, 4-nitro-3-(trifluoromethyl)-
4-Nitro-α,α,α-trifluoro-m-toluidine
3-Trifluoromethyl-4-nitroaniline
4-Nitro-3-(trifluoromethyl) aniline (3-Amino-6-nitrobenzotrifluoride)
4-Nitro-3-aminobenzotrifluoride
4-Nitro-3-trifluoromethylaniline(Flutamide impurity)
5-Amino-2-nitrobenzotrifluoride,97%
5-Amino-2-nitrobenzotrifluoride 98%
5-Amino-2-nitrobenzotrifluoride98%
2-NITRO-5-AMINOBENZOTRIFLUORIDE(3-TRIFLUOROMETHYL-4-NITROANILINE)
3-trifluoromethyl-4-nitroanilide
4-Nitro-3-(trifluormethyl)anilin
3-trifluoromethyl-4-nitroaniune
2-Nitro-5-aminobenzotriluoride
5-Amino-2-nitrobenzotrifluoride >
Nilutamide impurity B CRS
Nilutamide Impurity 3
4-NITRO-3-TRIFLUOROMETHYL ANILINE CAS NO 393-11-3
Flutamide Impurity 1 (Flutamide EP Impurity A)
TIANFU-CHEM 4-Nitro-3-trifluoromethyl aniline
Flutamide Related Compound A (4-nitro-3-(trifluoromethyl)aniline) (1285997)
4-Nitro-3-Triflouromethyl Aniline (Flutamide Intermediate)
Flutamide ImpurityⅠ:4-Nitro-3-(trifluoromethyl)aniline
α,α,α-Trifluoro-4-nitro-m-toluidine
4-nitro-3-(trifluoromethyl)benzeneamine
Flutamide Impurity A
Flutamide USP Related Compound A
4-nitro-3-(trifluoromethyl)aniline (nifeline)
Flutamide EP Impurity A（Nilutamide EP Impurity B）
393-11-3
Organic Building Blocks
Nitrogen Compounds
C7
Amines
Building Blocks
Anilines, Aromatic Amines and Nitro Compounds
Amines
Phenyls & Phenyl-Het
Phenyls & Phenyl-Het
Trifluoromethylbenzene serise
Amines, Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals